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Our results suggest that, as in the CNS, CADM1 interactions drive exocytic site assembly and promote actin network formation. These results support the broader hypothesis that the effects of cell-cell contact on beta-cell maturation and function are mediated by the same extracellular protein interactions that drive the formation of the presynaptic exocytic machinery. These interactions may be therapeutic targets for re...
A significant interactive two-locus model of STX1A_rs4363087|VAMP2_rs2278637 (presynaptic genes) was observed among SVC (zeige COL4A1 Proteine) variants in all epilepsy cases.
Mislocalization of syntaxin-1 was found in pluripotent stem cells from epileptic encephalopathy patient.
Blockade of the SNARE (zeige NAPA Proteine) protein syntaxin 1 inhibits glioblastoma tumor growth.
SNARE (zeige NAPA Proteine) complex genes and their interactions may play a significant role in susceptibility and working memory of ADHD.
We described clinical, genetic, and functional data from 17 families with a diagnosis of benign familial neonatal epilepsy caused by KCNQ2 (zeige KCNQ2 Proteine) or KCNQ3 mutations and we showed that some mutations lead to a reduction of Q2 channel regulation by syntaxin-1A.
no associaton with idiopathic generalized epilepsy was found regarding Intron 7 rs1569061 of Syntaxin 1A gene, MnlI rs3746544 and DdeI rs1051312 polymorphisms of SNAP-25 (zeige SNAP25 Proteine) gene compared with healthy subjects
The clinical relevance of STX1A variants in CF
PIP2 affects islet beta-cell KATP channels not only by its actions on Kir6.2 but also by sequestering Syn-1A to modulate Syn-1A availability and its interactions with SUR1 on PM.
Prefusion structure of syntaxin-1A suggests pathway for folding into neuronal trans-SNARE (zeige NAPA Proteine) complex fusion intermediate.
Syntaxin 1A drives fusion of large dense-core neurosecretory granules into a planar lipid bilayer
microdomains carrying syntaxin1/SNAP-25 (zeige SNAP25 Proteine) and different types of calcium channels act as the sites for physiological granule fusion in "in situ" chromaffin cells
The role of syntaxin 1A in GLP1 (zeige GCG Proteine) release from intestinal cells as a response to external stimuli is reported.
proteins, such as syntaxin-1, Munc18-1, or SNAP-25, modulate alpha-synuclein neuropathy and/or are dysregulated in Alzheimer's disease, understanding this type of neurodegeneration may provide new links between synaptic defects and neurodegeneration in humans
Therefore, our work provides insights into differential functions of Stx1 in neuronal maintenance and neurotransmission, with the latter explored further into its functions in vesicle docking and fusion.
Syn (zeige SYP Proteine)-1A actions on newcomer SGs (zeige SKI Proteine) were partly mediated by Syn (zeige SYP Proteine)-1A interactions with newcomer SG VAMP8 (zeige VAMP8 Proteine)
The results of this study suggested that STX1A plays an important role in social behavior through regulation of the OXTergic neural system.
Data suggest that porosome-associated proteins SNAP25 (zeige SNAP25 Proteine), TREK-1 (zeige KCNK2 Proteine), syntaxin-1A, and Gai3 exhibit stability and functionality such that isolated proteins can be reconstituted as insulin (zeige INS Proteine)-secreting porosomes in cell membrane of live cells.
syntaxin 1 and vesicle-associated membrane protein 1 (zeige VAMP1 Proteine) are more suitable targets to abolish functional soluble N-ethylmaleimide-sensitive factor attachment protein receptor (zeige VTI1B Proteine) complexes
Data show a significant increase of vesicle-associated membrane protein 2 (VAMP-2 (zeige VAMP2 Proteine)) mRNA expression, however, the expressions of synaptosome-associated protein of 25 kDa (SNAP-25 (zeige SNAP25 Proteine)) and syntaxin 1A did not exhibit the changes in hippocampus.
Although STX1A and STX1B (zeige STX1B Proteine) share a basic function as neuronal t-SNAREs, STX1B (zeige STX1B Proteine) but not STX1A is necessary for the regulation of spontaneous and evoked synaptic vesicle exocytosis in fast transmission.
we found that STX1A and STX1B (zeige STX1B Proteine) play distinct roles in neuronal survival using
The authors found two syntaxin1A mutations that confer opposite general anesthesia phenotypes
Data suggest that Ca(2 (zeige CA2 Proteine)+)-CaM regulation of V100 may control SNARE (zeige NAPA Proteine) complex assembly for a subset of synaptic vesicles that sustain spontaneous release.
these results indicate that SNAP-25 (zeige SNAP25 Proteine)-R206 and syntaxin (zeige STX4 Proteine)-D253 play a major role in neuroexocytosis and support a radial assembly of several SNARE (zeige NAPA Proteine) complexes interacting via the ionic couple formed by these two residues.
Syntaxin1A domain formation is induced by phosphoinositide-3,4,5-triphosphate; this clustering is dependent on positively charged residues in the juxtamembrane domain.
The Syx1A dependent trafficking of Grk (zeige GRK4 Proteine) protein is required for efficient EGFR (zeige EGFR Proteine) signaling during dorsal-ventral patterning.
analysis of epistatic interactions related to mutation of Syx1A
Syntaxin 1A molecules share a conserved threonine in C-terminal +7 layer near transmembrane domain. Mutation of threonine to isoleucine results in a structural change that resembles those found in syntaxins ascribed to the constitutive secretory pathway
This gene encodes a member of the syntaxin superfamily. Syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane. Syntaxins possess a single C-terminal transmembrane domain, a SNARE
neuron-specific antigen HPC-1
, synaptotagmin-associated 35 kDa protein
, syntaxin 1A (brain)-like
, syntaxin 1A (brain)
, syntaxin 1 a
, syntaxin 1
, syntaxin 1A
, syntx 1