anti-GATA4 (GATA4) Antikörper

Xenopus laevis GATA Binding Protein 4 (GATA4) Interaktionspartner

1. Data show that GATA4 or 6 regulate both cardiogenic potential and subsequent cardiomyocyte differentiation but that GATA5 is involved in regulating cardiomyocyte differentiation.

2. Results describe the expression of GATA4 and 6 during gastrulation and their function in migratory behaviour.

3. The data demonstrate that KLF13 is an important component of the transcription network required for heart development and suggest that KLF13 is a GATA-4 modifier

4. Data show that GATA4 knockdown only affects cardiac marker expression in the absence of either GATA5 or GATA6, suggesting redundancy in this family during myocardial development.

Rabbit GATA Binding Protein 4 (GATA4) Interaktionspartner

1. These results indicate a higher capacity of adipose-derived than bone marrow-derived mesenchymal stem cells to express GATA4.

Human GATA Binding Protein 4 (GATA4) Interaktionspartner

1. Study identified novel mutations in GATA4 with relatively higher mutation frequency of 7.7% in a cohort of patients with Tetralogy of Fallot (TF). Five of them are novel and located in the N-terminal transactivation domain and first zinc finger domain. Most of the C-terminal variants are polymorphic. These result not only supports the important role of GATA4 in TG but also expands the spectrum of mutations in GATA4.

2. the DNA variants may alter GATA4 gene promoter activity and affect GATA4 levels, thus contributing to AMI development.

3. Two GATA4 SNPs rs368418329, rs56166237 are associated with congenital heart disease in Egyptian children.

4. The aim of this study was to screen a Moroccan cohort with tetralogy of Fallot for GATA4 mutations, and to assess environmental risk factors that could be involved in the occurrence of this disorder.

5. Study demonstrates that GATA4 functions as a tumor suppressor in lung cancer. Mechanistically, GATA4 upregulates multiple miRNAs targeting TGFB2 mRNA and causes ensuing WNT7B downregulation and eventually triggers cell senescence. Targeting the TGF-beta signaling provides a potential way for the treatment of GATA4-deficient lung cancer.

6. Comprehensive computational analysis, using well-established web based tools, is suggestive of their potential downstream molecular effects on the structure, stability and expression of GATA4 protein

7. abnormal lamin. proteins trigger paracrine senescence through GATA4-dependent pathway in human mesenchymal stem cells.

8. The findings support the fact that rare functional variants especially in GATA4 could be associated with BAV, adding novel genetic factors to the list of variants associated with the phenotypic expression of this genetically complex pathology.

9. we found two known SNPs (rs56166237, rs3729856) in GATA4. Our study shows no evidence of NKX2-5 and GATA4 somatic mutations playing a role in the pathogenesis of sporadic Congenital Heart Disease.

10. data indicate that GATA4 gene might play a role in cell proliferation and differentiation during the progression of pancreatic cancer.

11. findings demonstrate that RACK1 is involved in p300/GATA4-dependent hypertrophic responses in cardiomyocytes and is a promising therapeutic target for heart failure

12. Studied prevalence of GATA binding protein 4 (GATA4) exon 1 mutation in Egyptian patients with isolated congenital heart defects.

13. The single nucleotide polymorphisms (SNPs) of NKX2.5, GATA4, and TBX5 are highly associated with congenital heart diseases in the Chinese population, but not significant in the SNPs of FOG2.

14. direct binding of GATA4 to the GNAI3 promoter, both in vitro and in vivo, is reported.

15. Report a genome-wide association scan of 466 bicuspid aortic valve cases and 4,660 age, sex and ethnicity-matched controls with replication in up to 1,326 cases and 8,103 controls. We identify association with a noncoding variant 151 kb from the gene encoding the cardiac-specific transcription factor, GATA4, and near-significance for p.Ser377Gly in GATA4.

16. GATA4 variants were not associated with Alcohol Use Disorder (AUD) in either the European ancestry or African ancestry groups after correcting for multiple comparisons. Rs10112596 demonstrated a significant relationship with an anxiety measure among the African ancestry group with AUD.

17. High GATA4 expression is associated with mesenchymal and migratory phenotype of hepatoblastoma cells.

18. GATA4 may inhibit diabetesinduced endothelial dysfunction by acting as a transcription factor for NOX4 expression.

19. GATA4 acetylation activated CCND2 transcription, and mutation of GATA4 on K-313 reduced cell viability and increased a mitochondria-dependent apoptosis.

20. we found two nucleotide deletions which one of them was novel and one new indel mutation resulting in frame shift mutation, and 4 synonymous variations or polymorphism in 6 of patients and 3 of normal individuals

Pig (Porcine) GATA Binding Protein 4 (GATA4) Interaktionspartner

1. investigation of genes regulated by GATA4, GATA6, and both in combination: studies in granulosa cells primed for luteinization

2. GATA-4 and C/EBPbeta are both required for FSH +/- IGF-I stimulation of the porcine steroidogenic acute regulatory protein gene promoter in homologous granulosa cell cultures.

3. The altered ratio of GATA4 to GATA6 after ovulation may allow GATA6 to enhance STAR mRNA accumulation.

Mouse (Murine) GATA Binding Protein 4 (GATA4) Interaktionspartner

1. Gata4-dependent differentiation of c-Kit(+)-derived endothelial cells underlies artefactual cardiomyocyte regeneration in the heart.

2. Gata4 is an important modulator balancing the promoting and inhibitory effects of oxidative stress on differentiation program of cardiomyogenesis.

3. GATA4 knockdown differentially expressed BARX1 and affects the development of neural crest cells derivatives.

4. Data indicate a function of GATA binding protein 4 (GATA4) as a cardiac repressor of the transcription factor 7-like 2 protein (TCF7L2)/beta-catenin complex.

5. GATA4 directly represses RANKL expression via seven cis-regulatory regions and plays an important role in maintaining proper bone development and osteoclast formation.

6. Meox1 accelerated myocardial hypertrophic decompensation via the downstream target Gata4, at least in part directly.

7. inhibitory action of GATA4 on testicular peritubular myoid cell contraction mediated at least partly by regulating genes belonging to smooth muscle contraction pathway

8. miR-429 expression levels were upregulated in cultured neurons with OGD/R treatment. The downregulation of miR-429 significantly alleviated oxygen-glucose deprivation and reoxygenation-induced neuronal injury, whereas upregulation of miR-429 aggravated it. miR-429 could directly target the 3'-untranslated region of GATA4. miR-429 negatively regulated GATA4 expression.

9. Rere and Gata4 interact genetically in the development of congenital heart defects.

10. direct binding of GATA4 to the GNAI3 promoter, both in vitro and in vivo, is reported.

11. Downregulation of Gata4 could restore the phenotype exhibited by Wnt3 downregulation in dorsal root ganglion neurons.

12. Enrichment of induced cardiomyocytes derived from mouse fibroblasts can be achieved by reprogramming with cardiac transcription factors, Gata4, MEF2c, Tbx5, and Hand2.

13. GATA4/6 are key regulators of steroidogenesis and testicular somatic cell survival.

14. Observations identify Gata4 as a novel crucial regulator of the intestinal epithelial barrier and as a critical epithelial transcription factor implicated in the maintenance of proximal intestinal mucosal integrity after injury.

15. Gata4 mutants also demonstrated Hedgehog (Hh) signaling defects.

16. disruption of GATA4-mediated transactivation in hepatocellular carcinoma suppresses hepatocyte epithelial differentiation to sustain replicative precursor phenotype

17. Mechanistically, decreased GATA4 levels caused the downregulation of several pro-regenerative genes (among them interleukin-13, Il13) in the myocardium.

18. GATA4 acts as master regulator of hepatic microvascular specification and acquisition of organ-specific vascular competence, which are indispensable for liver development.

19. study provides novel insights into the role of WT1 and GATA4 during the sex differentiation phase and represents an approach that can be applied to assess other proteins with as yet unknown functions during gonadal development

20. we have identified a distinct lineage of adult HSCs characterized by its derivation of progenitors where Gata4 expression is activated by a specific enhancer. Most adult HSCs belonging to this lineage probably originate in the placenta.

Cow (Bovine) GATA Binding Protein 4 (GATA4) Interaktionspartner

1. The activity of Gata4 cardiac enhancer in transgenic embryos and in cultured aortic endothelial cells is dependent on four ETS sites.

Zebrafish GATA Binding Protein 4 (GATA4) Interaktionspartner

1. Study finds that emergent juvenile cortical cardiomyocytes induce expression of gata4 in a manner similar to during regeneration.

2. ATOH8, GATA4, and FOG2 associate in a single complex

3. gata4 gene regulates sdf1a levels during early embryogenesis

4. mga restricts the normal levels of Gata4 required for heart tube looping.

5. Through the use of a transgenic reporter strain, we found that cardiomyocytes throughout the subepicardial ventricular layer trigger expression of the embryonic cardiogenesis gene gata4 within a week of trauma

6. Gata4 and Gata6 have distinct non-redundant functions in cardiac morphogenesis, but are redundant for an early step of liver development; and Gata4 and Gata6 are essential and non-redundant for liver growth following initial budding

7. Data show that GATA4 knockdown only affects cardiac marker expression in the absence of either GATA5 or GATA6, suggesting redundancy in this family during myocardial development.

8. Results suggest that GATA4 and -6 play a key role in the regulation of ventricular myosin heavy chain gene expression in the ventricle.