P5CS Produkte
(Aldehyde Dehydrogenase 18 Family, Member A1 (ALDH18A1))
Kategorien
This gene is a member of the aldehyde dehydrogenase family and encodes a bifunctional ATP- and NADPH-dependent mitochondrial enzyme with both gamma-glutamyl kinase and gamma-glutamyl phosphate reductase activities. The encoded protein catalyzes the reduction of glutamate to delta1-pyrroline-5-carboxylate, a critical step in the de novo biosynthesis of proline, ornithine and arginine. Mutations in this gene lead to hyperammonemia, hypoornithinemia, hypocitrullinemia, hypoargininemia and hypoprolinemia and may be associated with neurodegeneration, cataracts and connective tissue diseases. Alternatively spliced transcript variants, encoding different isoforms, have been described for this gene. [provided by RefSeq, Jul 2008].
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Ausgewählte P5CS Kategorien
P5CS Antikörper
High quality antibodies with extensive validation data.
P5CS ELISA Kits
Reliable ELISA kits for a wide range of species.
P5CS Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene P5CS Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Applikation
WB, ELISA
Validierungen
- (1)
- (3)
Kat. Nr.
ABIN519568
Menge
100 μg
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB, FACS, IHC (p)
Validierungen
- (3)
Kat. Nr.
ABIN652885
Menge
400 μL
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB, ELISA
Validierungen
- (1)
Kat. Nr.
ABIN562547
Menge
50 μL
Datenblatt
Datenblatt
Empfohlene P5CS ELISA Kits
Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Competition ELISA
Validierungen
Kat. Nr.
ABIN770580
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Pig
Analytical Method
Quantitative
Validierungen
Kat. Nr.
ABIN778158
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Rabbit
Analytical Method
Quantitative Competition ELISA
Validierungen
Kat. Nr.
ABIN774259
Menge
96 tests
Datenblatt
Datenblatt
Empfohlene P5CS Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
Escherichia coli (E. coli)
Validierungen
- (1)
Kat. Nr.
ABIN7121771
Menge
50 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1344810
Menge
10 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1344809
Menge
25 μg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren P5CS Produkten
: "Disruption of Proline Synthesis in Melanoma Inhibits Protein Production Mediated by the GCN2 Pathway." in: Molecular cancer research : MCR, Vol. 13, Issue 10, pp. 1408-20, (2016) (PubMed).: "Severe congenital cutis laxa with cardiovascular manifestations due to homozygous deletions in ALDH18A1." in: Molecular genetics and metabolism, Vol. 112, Issue 4, pp. 310-6, (2014) (PubMed).
: "Nuclear cytoplasmic trafficking of proteins is a major response of human fibroblasts to oxidative stress." in: Journal of proteome research, Vol. 13, Issue 10, pp. 4398-423, (2014) (PubMed).
: "Functional specialization in proline biosynthesis of melanoma." in: PLoS ONE, Vol. 7, Issue 9, pp. e45190, (2012) (PubMed).
: "Systematic validation of antibody binding and protein subcellular localization using siRNA and confocal microscopy." in: Journal of proteomics, Vol. 75, Issue 7, pp. 2236-51, (2012) (PubMed).
: "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score." in: Molecular medicine (Cambridge, Mass.), Vol. 16, Issue 7-8, pp. 247-53, (2010) (PubMed).
: "Global Metabolic Profiling Identifies a Pivotal Role of Proline and Hydroxyproline Metabolism in Supporting Hypoxic Response in Hepatocellular Carcinoma." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 24, Issue 2, pp. 474-485 (PubMed).
Synonyme und alternative Namen zu P5CS
aldehyde dehydrogenase 18 family member A1 (ALDH18A1), aldehyde dehydrogenase 18 family member A1 (aldh18a1), aldehyde dehydrogenase 18 family, member A1 (ALDH18A1), aldehyde dehydrogenase 18 family, member A1 (Aldh18a1), aldehyde dehydrogenase 18 family, member A1 (aldh18a1), aldehyde dehydrogenase 18 family member A1 L homeolog (aldh18a1.L), aldehyde dehydrogenase 18 family member A1 (Aldh18a1), 2810433K04Rik, AI429789, ALDH18A1, ARCL3A, cb842, cb899, GSAS, P5CS, PYCS, Pycs, pycs, sb:cb881, wu:fa91f10, wu:fi05f11, wu:fi17d12Bezeichner auf Proteinebene für P5CS
- pyrroline-5-carboxylate synthetase
- aldehyde dehydrogenase 18 family, member A1
- Delta-1-pyrroline-5-carboxylate synthetase
- P5CS
- aldehyde dehydrogenase 18A1
- aldehyde dehydrogenase family 18 member A1
- delta-1-pyrroline-5-carboxylate synthase
- aldehyde dehydrogenase 18A1-like
- delta-1-pyrroline-5-carboxylate synthetase
- delta1-pyrroline-5-carboxlate synthetase
- pyrroline-5-carboxylate synthetase (glutamate gamma-semialdehyde synthetase)
- glutamate gamma-semialdehyde synthetase
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