anti-Complement Factor H (CFH) Antikörper

Bezeichnung:: anti-Complement Factor H Antikörper (CFH)

Auf www.antikoerper-online.de finden Sie aktuell 306 Complement Factor H (CFH) Antikörper von 28 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen Complement Factor H Kits (71) und Complement Factor H Proteine (19) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 405 Complement Factor H Produkte verfügbar.

Synonyme:: AHUS1, AMBP1, armd4, arms1, cfh, cfhl3, fH, fhl1, HF, hf1, hf2, hus, im:7147412, Mud-1, NOM, Sas-1, Sas1, si:ch211-207o17.2

Alle Antikörper anzeigen	Gen	GeneID	UniProt
	CFH	3075	P08603
	CFH	12628	P06909
	CFH	155012
Alle Spezies anzeigen Weitere Synonyme anzeigen

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anti-Human Complement Factor H Antikörper:

anti-Mouse (Murine) Complement Factor H Antikörper:

anti-Rat (Rattus) Complement Factor H Antikörper:

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Am meisten referenzierte anti-Complement Factor H Antikörper

Human Monoclonal Complement Factor H Primary Antibody für IP, ELISA - ABIN2473069 : Fontaine, Demares, Koistinen, Day, Davrinche, Sim, Ripoche: Truncated forms of human complement factor H. in The Biochemical journal 1989 (PubMed)
Show all 4 Pubmed References
Human Monoclonal Complement Factor H Primary Antibody für IHC (fro), FACS - ABIN2473067 : Harrison, Lachmann: The physiological breakdown of the third component of human complement. in Molecular immunology 1980 (PubMed)
Show all 2 Pubmed References
Human Polyclonal Complement Factor H Primary Antibody für ELISA, WB - ABIN250548 : Klein, Zeiss, Chew, Tsai, Sackler, Haynes, Henning, SanGiovanni, Mane, Mayne, Bracken, Ferris, Ott, Barnstable, Hoh: Complement factor H polymorphism in age-related macular degeneration. in Science (New York, N.Y.) 2005 (PubMed)
Human Polyclonal Complement Factor H Primary Antibody für ID, WB - ABIN253380 : Radu, Hu, Yuan, Welch, Makshanoff, Lloyd, McMullen, Travis, Bok: Complement system dysregulation and inflammation in the retinal pigment epithelium of a mouse model for Stargardt macular degeneration. in The Journal of biological chemistry 2011 (PubMed)

Weitere Antikörper gegen Complement Factor H Interaktionspartner

Human Complement Factor H (CFH) Interaktionspartner

Mutation in CFH gene is associated with age-related macular degeneration.
CC rs1061170 CFH genotype may be associated with the age-related macular degeneration. Additionally, CC rs1061170 CFH genotype may promote a negative response to anti-VEGF (zeige VEGFA Antikörper) treatment, while patients with TT rs1061170 CFH genotype showed better functional and structural response to anti-VEGF (zeige VEGFA Antikörper) agents.
Our analysis showed stronger contribution of ARMS2 (zeige ARMS2 Antikörper) in age-related macular degeneration (AMD (zeige AMD1 Antikörper)) with reticular pseudodrusen (RPD) group versus AMD (zeige AMD1 Antikörper) without RPD group, in comparison with CFH genotypes.
Study demonstrated that a novel complotype composed of CFB (zeige CFB Antikörper) (rs4151667) in combination with CFB (zeige CFB Antikörper) (rs641153) and CFH(rs800292) is strongly associated with complement activation and age-related macular degeneration status.
Mapping rare, deleterious mutations in Factor H: Association with early onset, drusen burden, and lower antigenic levels in familial AMD (zeige AMD1 Antikörper).
AMD (zeige AMD1 Antikörper) patients had significantly elevated nitrated CFH levels compared to controls (p = 0.0117). These findings strongly suggest that nitrated CFH contributes to AMD (zeige AMD1 Antikörper) progression, and is a target for therapeutic intervention.
inhibition of the alternative pathway by factor H, with a concentration equivalent to a high physiological level, strongly reduced C5a levels and decreased proinflammatory cytokine production in human peripheral blood mononuclear cells.
Complement factor H Y402H (rs1061170) and age-related maculopathy susceptibility2 (ARMS2 (zeige ARMS2 Antikörper))/LOC387715 A69S (rs10490924) polymorphisms shown to have significant association with age-related macular degeneration (Meta-Analysis).
Regression analysis showed that ARMS2 (zeige ARMS2 Antikörper) TT genotype has a statistically significant effect on retinal angiomatous proliferation versus age-related macular degeneration compared to CFH genotypes (P < 0.001).
This study enclosed strong synergistic association of risk genotypes of C3 and CFH Y402H with AMD (zeige AMD1 Antikörper). We also revealed synergistic influence of CCL2 (zeige CCL2 Antikörper)-2518 and the at-risk genotype of the C3 in AMD (zeige AMD1 Antikörper) with an estimated AP = 50.9% (adjusted AP = 24.7%). Present findings show that CCL2 (zeige CCL2 Antikörper)-2518 polymorphism is not an innocent bystander (zeige SEPT1 Antikörper) in AMD (zeige AMD1 Antikörper) susceptibility when combined with the at-risk genotype of C3 (R102G).

Pig (Porcine) Complement Factor H (CFH) Interaktionspartner

Mouse (Murine) Complement Factor H (CFH) Interaktionspartner

this study shows that complement regulatory protein (zeige TGFB1 Antikörper) Factor H is a soluble prion (zeige PRNP Antikörper) receptor that potentiates peripheral prion (zeige PRNP Antikörper) pathogenesis
Factor H and Crry (zeige CR1L Antikörper) are critical for regulating complement activation at distinct anatomic sites within the kidney.
VEGF (zeige VEGFA Antikörper) inhibition decreases local CFH and other complement regulators in the eye and kidney through reduced VEGFR2 (zeige KDR Antikörper)/PKC-alpha (zeige PKCa Antikörper)/CREB (zeige CREB1 Antikörper) signaling.
environmental factors can drive retinal disease in these mice when linked to complement deficits impairing immune function. Both groups of mice had similar levels of retinal amyloid beta accumulation. Consequently there is no direct link between this and inflammation in Cfh(-/-) mice.
absence of plasma CfH conferred susceptibility to glomerulonephritis
This new understanding of the complicated interactions of CFH in AMD (zeige AMD1 Antikörper)-like pathology provides an improved foundation for the development of targeted therapies for AMD (zeige AMD1 Antikörper)
data suggest that altered interactions of Cfh with MDA-modified proteins may be relevant in explaining the effects of the Cfh variant.
Cfh and Cfhr2 (zeige CFHR2 Antikörper) genes are expressed in the mouse outer retina. Only Cfh mRNA was detected in the retinal pigment epithelium, but no protein.
A spectrum of complement dysregulation was modeled on the APOE4 age related macular degeneration mouse model by crossing these mice to complement factor H knockout (cfh-/-) mice to test the impact of excess complement activation.
Data indicate that co-deficiency of factor H (FH) and MASP-1/MASP-3 (zeige MASP1 Antikörper) did not ameliorate either the plasma Complement C3 (zeige C3 Antikörper) (C3) activation or glomerular C3 accumulation in FH-deficient mice.

Chimpanzee Complement Factor H (CFH) Interaktionspartner

interaction between sialylated Neisseria gonorrhoeae and factor H [factor H]

Zebrafish Complement Factor H (CFH) Interaktionspartner

Results report the molecular cloning and identification of complement factor H and complement factor H-like 1-4 (CFHL1 (zeige CFHR1 Antikörper)-4) in Danio rerio.

Complement Factor H (CFH) Antigen-Profil

Beschreibung des Gens

This gene is a member of the Regulator of Complement Activation (RCA) gene cluster and encodes a protein with twenty short consensus repeat (SCR) domains. This protein is secreted into the bloodstream and has an essential role in the regulation of complement activation, restricting this innate defense mechanism to microbial infections. Mutations in this gene have been associated with hemolytic-uremic syndrome (HUS) and chronic hypocomplementemic nephropathy. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Alternative names and synonyms associated with Complement Factor H (CFH)

complement factor H (CFH) Antikörper
complement component factor h (Cfh) Antikörper
complement factor H (Cfh) Antikörper
complement factor H (cfh) Antikörper
complement factor H-related protein 5 (LOC100399888) Antikörper
complement factor H (LOC100733902) Antikörper
complement factor H L homeolog (cfh.L) Antikörper

AHUS1 Antikörper
AMBP1 Antikörper
armd4 Antikörper
arms1 Antikörper
cfh Antikörper
cfhl3 Antikörper
fH Antikörper
fhl1 Antikörper
HF Antikörper
hf1 Antikörper
hf2 Antikörper
hus Antikörper
im:7147412 Antikörper
Mud-1 Antikörper
NOM Antikörper
Sas-1 Antikörper
Sas1 Antikörper
si:ch211-207o17.2 Antikörper

Bezeichner auf Proteinebene für CFH

H factor 1 (complement) , H factor 2 (complement) , adrenomedullin binding protein , age-related maculopathy susceptibility 1 , beta-1-H-globulin , beta-1H , factor H , factor H-like 1 , complement regulator factor H , complement factor H , complement factor H related protein 3A4/5G4 , protein beta-1-H , complement component factor H , complement inhibitory factor H , platelet complement factor H , complement factor H L homeolog

GENE ID	SPEZIES
3075	Homo sapiens
397525	Sus scrofa
12628	Mus musculus
155012	Rattus norvegicus
280816	Bos taurus
429057	Gallus gallus
457601	Pan troglodytes
478952	Canis lupus familiaris
553297	Danio rerio
100051358	Equus caballus
100174982	Ovis aries
100340175	Oryctolagus cuniculus
100399888	Callithrix jacchus
100451270	Pongo abelii
100465619	Ailuropoda melanoleuca
100600041	Nomascus leucogenys
100733902	Cavia porcellus
379371	Xenopus laevis

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