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anti-Human Complement Factor H Antikörper:
anti-Mouse (Murine) Complement Factor H Antikörper:
anti-Rat (Rattus) Complement Factor H Antikörper:
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Human Monoclonal Complement Factor H Primary Antibody für IP, ELISA - ABIN2473069
Fontaine, Demares, Koistinen, Day, Davrinche, Sim, Ripoche: Truncated forms of human complement factor H. in The Biochemical journal 1989
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Human Monoclonal Complement Factor H Primary Antibody für IHC (fro), FACS - ABIN2473067
Harrison, Lachmann: The physiological breakdown of the third component of human complement. in Molecular immunology 1980
Show all 2 Pubmed References
Human Polyclonal Complement Factor H Primary Antibody für ID, WB - ABIN253380
Radu, Hu, Yuan, Welch, Makshanoff, Lloyd, McMullen, Travis, Bok: Complement system dysregulation and inflammation in the retinal pigment epithelium of a mouse model for Stargardt macular degeneration. in The Journal of biological chemistry 2011
Two rare age-related macular degeneration-associated variants in the CFH gene (rs121913059 [p.Arg1210Cys] and rs35292876) deviate in frequency among different geographic regions.
Mutation in CFH gene is associated with age-related macular degeneration.
CC rs1061170 CFH genotype may be associated with the age-related macular degeneration. Additionally, CC rs1061170 CFH genotype may promote a negative response to anti-VEGF (zeige VEGFA Antikörper) treatment, while patients with TT rs1061170 CFH genotype showed better functional and structural response to anti-VEGF (zeige VEGFA Antikörper) agents.
Our analysis showed stronger contribution of ARMS2 (zeige ARMS2 Antikörper) in age-related macular degeneration (AMD (zeige AMD1 Antikörper)) with reticular pseudodrusen (RPD) group versus AMD (zeige AMD1 Antikörper) without RPD group, in comparison with CFH genotypes.
Study demonstrated that a novel complotype composed of CFB (zeige CFB Antikörper) (rs4151667) in combination with CFB (zeige CFB Antikörper) (rs641153) and CFH(rs800292) is strongly associated with complement activation and age-related macular degeneration status.
Mapping rare, deleterious mutations in Factor H: Association with early onset, drusen burden, and lower antigenic levels in familial AMD (zeige AMD1 Antikörper).
AMD (zeige AMD1 Antikörper) patients had significantly elevated nitrated CFH levels compared to controls (p = 0.0117). These findings strongly suggest that nitrated CFH contributes to AMD (zeige AMD1 Antikörper) progression, and is a target for therapeutic intervention.
inhibition of the alternative pathway by factor H, with a concentration equivalent to a high physiological level, strongly reduced C5a levels and decreased proinflammatory cytokine production in human peripheral blood mononuclear cells.
Complement factor H Y402H (rs1061170) and age-related maculopathy susceptibility2 (ARMS2 (zeige ARMS2 Antikörper))/LOC387715 A69S (rs10490924) polymorphisms shown to have significant association with age-related macular degeneration (Meta-Analysis).
Regression analysis showed that ARMS2 (zeige ARMS2 Antikörper) TT genotype has a statistically significant effect on retinal angiomatous proliferation versus age-related macular degeneration compared to CFH genotypes (P < 0.001).
this study shows that complement regulatory protein (zeige TGFB1 Antikörper) Factor H is a soluble prion (zeige PRNP Antikörper) receptor that potentiates peripheral prion (zeige PRNP Antikörper) pathogenesis
Factor H and Crry (zeige CR1L Antikörper) are critical for regulating complement activation at distinct anatomic sites within the kidney.
VEGF (zeige VEGFA Antikörper) inhibition decreases local CFH and other complement regulators in the eye and kidney through reduced VEGFR2 (zeige KDR Antikörper)/PKC-alpha (zeige PKCa Antikörper)/CREB (zeige CREB1 Antikörper) signaling.
environmental factors can drive retinal disease in these mice when linked to complement deficits impairing immune function. Both groups of mice had similar levels of retinal amyloid beta accumulation. Consequently there is no direct link between this and inflammation in Cfh(-/-) mice.
absence of plasma CfH conferred susceptibility to glomerulonephritis
This new understanding of the complicated interactions of CFH in AMD (zeige AMD1 Antikörper)-like pathology provides an improved foundation for the development of targeted therapies for AMD (zeige AMD1 Antikörper)
data suggest that altered interactions of Cfh with MDA-modified proteins may be relevant in explaining the effects of the Cfh variant.
Cfh and Cfhr2 (zeige CFHR2 Antikörper) genes are expressed in the mouse outer retina. Only Cfh mRNA was detected in the retinal pigment epithelium, but no protein.
A spectrum of complement dysregulation was modeled on the APOE4 age related macular degeneration mouse model by crossing these mice to complement factor H knockout (cfh-/-) mice to test the impact of excess complement activation.
Data indicate that co-deficiency of factor H (FH) and MASP-1/MASP-3 (zeige MASP1 Antikörper) did not ameliorate either the plasma Complement C3 (zeige C3 Antikörper) (C3) activation or glomerular C3 accumulation in FH-deficient mice.
interaction between sialylated Neisseria gonorrhoeae and factor H [factor H]
Results report the molecular cloning and identification of complement factor H and complement factor H-like 1-4 (CFHL1 (zeige CFHR1 Antikörper)-4) in Danio rerio.
This gene is a member of the Regulator of Complement Activation (RCA) gene cluster and encodes a protein with twenty short consensus repeat (SCR) domains. This protein is secreted into the bloodstream and has an essential role in the regulation of complement activation, restricting this innate defense mechanism to microbial infections. Mutations in this gene have been associated with hemolytic-uremic syndrome (HUS) and chronic hypocomplementemic nephropathy. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
H factor 1 (complement)
, H factor 2 (complement)
, adrenomedullin binding protein
, age-related maculopathy susceptibility 1
, factor H
, factor H-like 1
, complement regulator factor H
, complement factor H
, complement factor H related protein 3A4/5G4
, protein beta-1-H
, complement component factor H
, complement inhibitory factor H
, platelet complement factor H
, complement factor H L homeolog