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We found that the percentage of T cells expressing IL-7R was significantly lower in both CD4(+) and CD8(+) T cell subsets blood and tissues in SIV-infected macaques than in healthy animals.
The CD4 (zeige CD4 Proteine)+CD25 (zeige IL2RA Proteine)+CD127low phenotype is found to be characteristic of regulatory cells found in mice and in rhesus macaques.
the results indicate that endogenous IL-7R signals promote Th1 (zeige HAND1 Proteine) and Tc1 (zeige C8orf4 Proteine) responses and IFN-gamma (zeige IFNG Proteine)- and TNF-alpha (zeige TNF Proteine) production to sustain the persistence of SS-like sialadenitis in NOD mice. These findings suggest that IL-7 (zeige IL7 Proteine) and Th1 (zeige HAND1 Proteine) cytokines could serve as promising therapeutic targets for this prevalent autoimmune disease.
show that the differentiation of group 3 ILCs is controlled by the glutamylation of IL-7Ralpha and the induction of transcription factor Sall3
results demonstrated that forced expression of IL-7R not only improved the functionality of tolerized CD8 (zeige CD8A Proteine) T cells, it also acted in synergy with PDL-1 (zeige CD274 Proteine) deficiency to further promote CD8 (zeige CD8A Proteine) T cell cytotoxicity to self antigens
IL-7 (zeige IL7 Proteine)/IL-7R signaling pathway plays a possible role in recurrent pregnancy loss by upregulating Th17 immunity while downregulating Treg immunity.
this study shows that short-term blockade of IL-7Ralpha induces detectable changes in co-inhibitory receptor expression and Treg frequencies in peripheral blood of NOD mice
results indicate that the induction of IL-7Ralpha expression on dendritic cells (DCs) is critical for thymic stromal lymphopoietin (zeige TSLP Proteine) responsiveness and that IL-4 (zeige IL4 Proteine) can upregulate IL-7Ralpha on DCs.
IL-7RA role in hematopoiesis and development of the lympho-myeloid progenitors in the developing fetal liver
These studies provide in vivo evidence that IL-7Ralpha signals positively regulate normal human B-cell production and proliferation beyond the fetal period and suggest that TSLP (zeige TSLP Proteine) can replace IL-7 (zeige IL7 Proteine) in providing these signals.
Bcl6 (zeige BCL6 Proteine) promoted T follicular helper cell differentiation through antagonizing IL-7R / STAT5a (zeige STAT5A Proteine) axis.
results suggest that LNK (zeige SH2B3 Proteine) suppresses IL-7R/JAK (zeige JAK3 Proteine)/STAT (zeige STAT1 Proteine) signaling to restrict pro-/pre-B progenitor expansion and leukemia development, providing a pathogenic mechanism and a potential therapeutic approach for B-ALLs with LNK (zeige SH2B3 Proteine) mutations.
EZH2 (zeige EZH2 Proteine) mutations coexisted with mutations of NOTCH1 (zeige NOTCH1 Proteine), IL7R, and PHF6 (zeige PHF6 Proteine) in the two Adult T-cell Acute Lymphoblastic Leukemia patients, and they responded poorly to chemotherapy and experienced difficult clinical histories and inferior outcomes
apicidin induced the acetylation of Forkhead box-containing protein, O subfamily 1, which acts as a repressor at the IL7R promoter, accompanied with depleted active histone modifications based on chromatin immunoprecipitation assay. Taken together, these results demonstrated that targeting oncogenic IL7R in ESCC by HDAC (zeige HDAC3 Proteine) inhibitors may be a valuable therapeutic approach.
In all, IL7RA locus polymorphisms could play an important role in the predisposition to multiple sclerosis, which could contribute to a better understanding the pathogenesis of multiple sclerosis.
The results confirm the association between IL7RA exon 6 sequence polymorphisms and increased susceptibility to multiple sclerosis.
The IL7RA rs6897932 polymorphism seems to be related to increased risk of liver fibrosis progression in HCV-infected patients. Thus, the rs6897932 polymorphism could be related to the physiopathology of chronic hepatitis C(CHC) and might be used to successfully stratify the risk of CHC progression.
indicate that IL7RhighSH2B3low expression distinguishes a novel subset of high-risk B-acute lymphoblastic leukemia associated with Ikaros (zeige IKZF1 Proteine) dysfunction
CD127 is a useful surface marker to isolate donor-antigen-specific-Tregs in operational tolerance after liver transplantation
Data demonstrate that IL-7R expression is regulated by HBX via NF-kappaB (zeige NFKB1 Proteine) and Notch1 (zeige NOTCH1 Proteine) pathways to facilitate the activation of intracellular pathways and expression of associated molecules, and contribute to proliferation and migration of hepatoma cells.
We show that heterozygous IL7R exon deletions are common in T-B+NK+ SCID (zeige PRKDC Proteine) and are detectable by WES. They should be considered if Sanger sequencing fails to detect homozygous or compound heterozygous IL7R SNVs or INDELs.
Data show a statistically significant association between a single nucleotide polymorphism (SNP) within the interleukin 7 receptor-encoding gene (IL7R) with high R. equi burden.
The protein encoded by this gene is a receptor for interleukine 7 (IL7). The function of this receptor requires the interleukin 2 receptor, gamma chain (IL2RG), which is a common gamma chain shared by the receptors of various cytokines, including interleukine 2, 4, 7, 9, and 15. This protein has been shown to play a critical role in the V(D)J recombination during lymphocyte development. This protein is also found to control the accessibility of the TCR gamma locus by STAT5 and histone acetylation. Knockout studies in mice suggested that blocking apoptosis is an essential function of this protein during differentiation and activation of T lymphocytes. The functional defects in this protein may be associated with the pathogenesis of the severe combined immunodeficiency (SCID).
interleukin 7 receptor
, interleukin-7 receptor subunit alpha-like
, IL-7 receptor alpha chain
, IL-7 receptor subunit alpha
, IL-7R subunit alpha
, interleukin 7 receptor alpha chain
, interleukin-7 receptor subunit alpha
, CD127 antigen
, interleukin 7 receptor isoform H5-6
, Interleukin-7 receptor subunit alpha-like protein
, Interleukin-7 receptor subunit alpha