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anti-Integrin Alpha2b (CD41) Antikörper

Bezeichnung:: anti-Integrin Alpha2b Antikörper (CD41)

Auf www.antikoerper-online.de finden Sie aktuell 454 Integrin Alpha2b (CD41) Antikörper von 31 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen Integrin Alpha2b Kits (13) und Integrin Alpha2b Proteine (10) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 480 Integrin Alpha2b Produkte verfügbar.

Synonyme:: AI172977, alphaIIb, BDPLT2, BDPLT16, CD41, CD41B, GP2B, GPIIb, GT, GTA, HPA3

Alle Antikörper anzeigen	Gen	GeneID	UniProt
	CD41	16399	Q9QUM0
	CD41	3674	P08514
	CD41
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anti-Mouse (Murine) Integrin Alpha2b Antikörper:

anti-Human Integrin Alpha2b Antikörper:

anti-Rat (Rattus) Integrin Alpha2b Antikörper:

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Verknüpfte Pathways mit anti-Integrin Alpha2b Antikörper

Integrin Complex

Weitere Produktkategorien zu Integrin Alpha2b Antikörper

Am meisten referenzierte anti-Integrin Alpha2b Antikörper

Mouse (Murine) Monoclonal Integrin Alpha2b Primary Antibody für FACS, IHC (fro) - ABIN320116 : Nieswandt, Echtenacher, Wachs, Schröder, Gessner, Schmidt, Grau, Männel: Acute systemic reaction and lung alterations induced by an antiplatelet integrin gpIIb/IIIa antibody in mice. in Blood 1999 (PubMed)
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Mouse (Murine) Monoclonal Integrin Alpha2b Primary Antibody für CyTox, IHC (fro) - ABIN2689249 : Bakewell, Nestor, Prasad, Tomasson, Dowland, Mehrotra, Scarborough, Kanter, Abe, Phillips, Weilbaecher: Platelet and osteoclast beta3 integrins are critical for bone metastasis. in Proceedings of the National Academy of Sciences of the United States of America 2003 (PubMed)
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Mouse (Murine) Monoclonal Integrin Alpha2b Primary Antibody für Func, IHC (f) - ABIN2749191 : Brancaleone, Gobbetti, Cenac, le Faouder, Colom, Flower, Vergnolle, Nourshargh, Perretti: A vasculo-protective circuit centered on lipoxin A4 and aspirin-triggered 15-epi-lipoxin A4 operative in murine microcirculation. in Blood 2013 (PubMed)
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Mouse (Murine) Monoclonal Integrin Alpha2b Primary Antibody für Func, IHC (f) - ABIN2749067 : Ramsey, Zhang, Brown, Steensma, Lin, Wu: Stress-induced hematopoietic failure in the absence of immediate early response gene X-1 (IEX-1, IER3). in Haematologica 2014 (PubMed)
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Mouse (Murine) Monoclonal Integrin Alpha2b Primary Antibody für FACS - ABIN119840 : Fujita, Takayama-Tsujimoto, Satoh, Gutiérrez, Aburatani, Fujii, Sarai, Bresnick, Yamamoto, Motohashi: NF-E2 p45 is important for establishing normal function of platelets. in Molecular and cellular biology 2013 (PubMed)
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Human Polyclonal Integrin Alpha2b Primary Antibody für IF (p), IHC (p) - ABIN748358 : Mei, Yin, Jin, He, Yin: The regulatory role of the adrenergic agonists phenylephrine and isoproterenol on fetal hemoglobin expression and erythroid differentiation. in Endocrinology 2013 (PubMed)
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Human Monoclonal Integrin Alpha2b Primary Antibody für FACS - ABIN536003 : Ferkowicz, Starr, Xie, Li, Johnson, Shelley, Morrison, Yoder: CD41 expression defines the onset of primitive and definitive hematopoiesis in the murine embryo. in Development (Cambridge, England) 2003 (PubMed)
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Human Monoclonal Integrin Alpha2b Primary Antibody für FACS - ABIN536004 : Zhang, Varas, Stadtfeld, Heck, Faust, Graf: CD41-YFP mice allow in vivo labeling of megakaryocytic cells and reveal a subset of platelets hyperreactive to thrombin stimulation. in Experimental hematology 2007 (PubMed)
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Human Monoclonal Integrin Alpha2b Primary Antibody für FACS - ABIN536005 : Mitjavila-Garcia, Cailleret, Godin, Nogueira, Cohen-Solal, Schiavon, Lecluse, Le Pesteur, Lagrue, Vainchenker: Expression of CD41 on hematopoietic progenitors derived from embryonic hematopoietic cells. in Development (Cambridge, England) 2002 (PubMed)
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Weitere Antikörper gegen Integrin Alpha2b Interaktionspartner

Mouse (Murine) Integrin Alpha2b (CD41) Interaktionspartner

Mimic chronic immune thrombocytopaenia using murine platelet induced model through immunized CD41-knockout mice.
alphaIIb beta3 antagonist TMV-7/trimucrin prevents thrombosis with causing Fc receptor gamma-chain IIa-mediated thrombocytopenia.
Kindlin supports platelet GPIIB IIIA activation by interacting with paxillin.
Platelets from Dok-1-/- mice displayed normal aggregation, activation of integrin alphaIIbbeta3, P-selectin surface expression, and soluble fibrinogen binding. These findings indicate that Dok-1 does not affect "inside-out" platelet signalling.
platelets clearly support early steps in pulmonary metastasis via GPIIb-dependent formation of platelet-tumor-aggregates
ITGA2b expression increases in response to immunization, raising the possibility that heterogeneous ITGA2b levels reflect variation in exposure to activation signals.
Thrombopoietin/MPL signaling confers growth and survival capacity to CD41-positive cells in a mouse model of Evi1 leukemia.
Direct binding of kindlin-3 to integrin alphaIIbbeta3 is involved in supporting integrin alphaIIbbeta3 activation and integrin alphaIIbbeta3-dependent responses of platelets and consequently contributes significantly to arterial thrombus formation.
ADAP interacts with talin and kindlin-3 to promote platelet Integrin alphaIIbbeta3 activation and stable fibrinogen binding.
reduction of talin-beta3 integrin binding affinity results in decelerated alphaIIbbeta3 integrin activation and protection from arterial thrombosis without pathological bleeding
deficiency of Dok-2 leads to dysregulated integrin alphaIIbbeta3-dependent cytosolic calcium flux and phosphatidylinositol(3,4)P2 accumulation.
Platelets lacking ERp57 have defective activation of the alphaIIbbeta3 integrin and platelet aggregation. The defect in aggregation was corrected by the addition of exogenous ERp57, implicating surface ERp57 in platelet aggregation.
Data indicate that Pyk2 is a common signaling effector downstream of both G12/13 and integrin alphaIIbbeta3 signaling, which contributes to thromboxane generation.
These results identify a novel pathway of integrin alphaIIbbeta3 outside-in signaling and recognize the tyrosine kinase Pyk2 as a major regulator of platelet adhesion and spreading on fibrinogen.
Here we show that platelet integrin CD41 (alphaIIb), currently thought to only transiently mark fetal hematopoietic stem cells, is expressed on an adult subtype that accumulates with age.
identified Hic-5 as a novel and specific regulatory factor for thrombin-induced alphaIIbbeta3 activation and subsequent platelet aggregation in mice.
These results suggested that platelet associated anti-alphaIIbbeta3 antibodies in primary primary immune thrombocytopenia tended to recognize highly restricted regions of alphaIIb with clonality.
Impaired spreading on fibrinogen and clot retraction with normal levels of alpha(IIb)beta(3) was observed in Lgals1(-/-) platelets, indicating a failure in the "outside-in" signaling through this integrin.
Glycoprotein IIb/IIIa-targeted microbubbles specifically bind to activated platelets in vitro, allowing real-time molecular imaging of acute arterial thrombosis in a mouse model.
Data indicate that the inflammatory cytokines TNF-alpha and IL-1 could be key components of the endothelial cell (EC) response and alphaIIb-beta3 integrin in platelets was required for late-phase thrombus stability.

Human Integrin Alpha2b (CD41) Interaktionspartner

alphaIIbbeta3 binding to polymeric fibrin can be segregated into two binding regimes, one with weaker rupture forces of 30-60 pN and a second with stronger rupture forces >60 pN that peaked at 70-80 pN.
ERp5 triggers fibrinogen dissociation from aIIbb3 integrin.
Hypoxia impairs agonist-induced CD41/CD61 activation and platelet aggregation.
ApoA-IV is a novel ligand of platelet GPIIB IIIA integrin.
mutations disturbing the alphaIIb R995/beta3 D723 salt bridge can cause an abnormal maturation of alpha-granules
ITGA2B gene mutations associated with Glanzmann thrombasthenia (Review)
Sanger sequencing of ITGA2B and ITGB3 in the index case followed by in silico modeling of all known GT-causing missense mutations extending from the lower part of the beta-propeller, and through the thigh and upper calf-1 domains. The index case, a Belgium type I GT patient, identiffied a homozygous c.1772A>C transversion (NC_000017.11:g.44379795T>G) affecting exon 18 of ITGA2B.
Kindlin supports platelet GPIIB IIIA activation by interacting with paxillin.
Type I Glanzmann thrombasthenia (GT)was found most common in our patients and with lowered mean CD41 expression in comparison with CD61. Type III GT patients had significantly lower numbers of severe bleeders, but the severity of bleeding did not vary significantly in type I and II GT patients
this study shows that in the Caucasian population the HPA-3 system confers susceptibility to acute cellular rejection after liver transplantation
Case Reports: alterations in the platelet proteome in type I Glanzmann thrombasthenia patients caused by different homozygous delG frameshift mutations in ITGA2B.
No genetic abnormalities identified in alpha2IIb and beta3: phenotype overcomes genotype in Glanzmann thrombasthenia.
study strongly supported the contribution of the genes ITGA2B, GSN and RHOA and the two pathways "regulation of actin cytoskeleton" and "leukocyte transendothelial migration" to osteoporosis risk.
A range of affinities from almost no interaction to the relatively high avidity that characterizes alphaIIbbeta3 is seen between various alpha subunits and beta1 transmembrane and cytosolic domains.
Meta-analysis found that glycoprotein Ia C807T T allele or the TT genotype, the Ser-allele of HPA-3 and B allele of glycoprotein Ibalpha variable number tandem repeat polymorphisms were associated with increased risk for ischemic stroke.
Furthermore, the inside-out activation of GPIIb/IIIa of platelets mediated Streptococcus suis suilysin-induced platelet aggregation.
Data suggest that the extreme C terminus of kindlin-2 is essential for interaction with and activation of integrin alphaIIBbeta3; these studies were conducted in macrophage cell line and erythroleukemia cell line.
Both in cell lines and in mouse model, the extracellular matrix receptors including the integrin ( ITGA3 and ITGA2B), collagen ( COL5A1), and laminin ( LAMA5) were significantly inhibited by curcumin at messenger RNA and protein levels.
Case Report: Reduced binding of mutant FLNa to beta3 and the facilitated recruitment of talin by beta3 on platelet stimulation, explaining the increased alphaIIbbeta3 activation and the ensuing gain-of-platelet functions.
Mechanistic basis for the binding of fibrinogen-derived RGD- and AGDV-peptides to the platelet integrin alphaIIb-beta3 has been described.

Integrin Alpha2b (CD41) Antigen-Profil

Beschreibung des Gens

ITGA2B encodes integrin alpha chain 2b. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 2b undergoes post-translational cleavage to yield disulfide-linked light and heavy chains that join with beta 3 to form a fibronectin receptor expressed in platelets that plays a crucial role in coagulation. Mutations that interfere with this role result in thrombasthenia. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling.

Alternative names and synonyms associated with Integrin Alpha2b (CD41)

integrin alpha 2b (Itga2b) Antikörper
integrin subunit alpha 2b (ITGA2B) Antikörper

AI172977 Antikörper
alphaIIb Antikörper
BDPLT2 Antikörper
BDPLT16 Antikörper
CD41 Antikörper
CD41B Antikörper
GP2B Antikörper
GPIIb Antikörper
GT Antikörper
GTA Antikörper
HPA3 Antikörper

Bezeichner auf Proteinebene für CD41

GP IIb , GPalpha IIb , alpha IIb , integrin alpha-IIb , platelet glycoprotein IIb of IIb/II Ia complex , platelet membrane glycoprotein IIb , platelet fibrinogen receptor, alpha subunit , platelet-specific antigen BAK

GENE ID	SPEZIES
16399	Mus musculus
3674	Homo sapiens

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Show all anti-Integrin Alpha2b (CD41) Antikörper with Pubmed References

Mouse (Murine) Integrin Alpha2b (CD41) Interaktionspartner

Human Integrin Alpha2b (CD41) Interaktionspartner

Beschreibung des Gens

Alternative names and synonyms associated with Integrin Alpha2b (CD41)

Bezeichner auf Proteinebene für CD41