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anti-Mouse (Murine) PLA2G5 Antikörper:
anti-Human PLA2G5 Antikörper:
anti-Rat (Rattus) PLA2G5 Antikörper:
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Cow (Bovine) Polyclonal PLA2G5 Primary Antibody für WB - ABIN2776806
Wootton, Arora, Drenos, Thompson, Cooper, Stephens, Hurel, Hurt-Camejo, Wiklund, Humphries, Talmud: Tagging SNP haplotype analysis of the secretory PLA2-V gene, PLA2G5, shows strong association with LDL and oxLDL levels, suggesting functional distinction from sPLA2-IIA: results from the UDACS study. in Human molecular genetics 2007
Show all 2 Pubmed References
Deficiency of GV sPLA2 (zeige PLA2G2A Antikörper) results in diminished glucose-stimulated insulin (zeige INS Antikörper) secretion in isolated pancreatic beta-cells
GV sPLA2 (zeige PLA2G2A Antikörper) is involved in the maintenance of tubular cell function and integrity, promoting sodium retention through increased cortical (Na+ + K+)-ATPase (zeige ATP1A1 Antikörper) expression and activity.
AdPLA2 plays an important role in promoting tumorigenesis and disease progression by modulating the production of prostaglandins and may serve as a potential therapeutic target in TSC (zeige SLC12A3 Antikörper) and LAM (zeige LSAMP Antikörper).
PLA2G5 hydrolyzed phosphatidylcholine (zeige SGMS2 Antikörper) in fat-overladen low-density lipoprotein to release unsaturated fatty acids, which prevented palmitate-induced M1 macrophage polarization.
Key Data shows the role of group v secreted phospholipase A2 (zeige YWHAZ Antikörper) in Th2 cytokine and dendritic cell-driven airway hyperresponsiveness and remodeling.
Our studies identified a unique function of gV-sPLA2 (zeige PLA2G2A Antikörper) in activation of macrophages
The impact of group V sPLA(2 (zeige PLA2G2A Antikörper)) deficiency on angiotensin (Ang) II (zeige AGT Antikörper)-induced cardiac fibrosis in apoE (zeige APOE Antikörper) deficient mice was investigated.
The results indicate that the PLA(2) activity also plays a substantial role in protecting cells against oxidant stress caused by an exogenous hydroperoxide.
GV sPLA(2 (zeige PLA2G2A Antikörper)) in bone marrow-derived myeloid cells as well as non-myeloid cells, which are likely bronchial epithelial cells, participate in the regulation of the innate immune response to pulmonary infection with E. coli.
Data from cuprizone-induced model of multiple sclerosis suggest that sPLA2 down-regulation during remyelination can limit release of AA and consequent production of pro-inflammatory PGs/TXB2 (which are increased during demyelination).
This report provides the first demonstration that Phosphatidylcholine-Isoprostanes are readily hydrolyzed by group IIA, V and X Secretory Phospholipases A2.
Low GV-PLA2 expression is associated with cancer.
Data show that phospholipase A2 group IIA, V and X have different target/function related activity.
The clinical findings in this family suggest a diagnosis of benign familial fleck retina with excellent prognosis, in which the PLA2G5 gene may play a role.
sPLA2 (zeige PLA2G2A Antikörper)-V plays a thrombogenic role by impairing the ability of EPCR (zeige PROCR Antikörper) to promote protein C activation.
results demonstrate that EPCR (zeige PROCR Antikörper) is overexpressed and mediates the aggressive behavior of rheumatoid synovial fibroblasts, and is likely driven by group V secretory phospholipase A2 (zeige YWHAZ Antikörper)
expression of PLA2s (zeige PLA2G2A Antikörper)-IIE and -V correlates with the development of calcification as well as the expression of pro-osteogenic molecules in human aortic valves
Summarizing, Der (zeige GDF3 Antikörper) p1 and Fel (zeige CREB3L2 Antikörper) d1 involve phospholipase A2 (zeige YWHAZ Antikörper) enzymes in their action.
There is no association between rs525380 polymorphism of PLA2G5 and coronary heart disease.
Our results demonstrate the association of the PLA2G5 rs11573191 polymorphism with premature CAD (zeige CAD Antikörper). In our study, it was possible to distinguish one haplotype associated with increased risk of premature CAD (zeige CAD Antikörper) and hypertension.
This gene is a member of the secretory phospholipase A2 family. It is located in a tightly-linked cluster of secretory phospholipase A2 genes on chromosome 1. The encoded enzyme catalyzes the hydrolysis of membrane phospholipids to generate lysophospholipids and free fatty acids including arachidonic acid. It preferentially hydrolyzes linoleoyl-containing phosphatidylcholine substrates. Secretion of this enzyme is thought to induce inflammatory responses in neighboring cells. Alternatively spliced transcript variants have been found, but their full-length nature has not been determined.
calcium-dependent phospholipase A2
, phospholipase A2, group V
, group V phospholipase A2
, phosphatidylcholine 2-acylhydrolase 5
, Ca2+-dependent phospholipase A2
, phospholipase A2, group 5