anti-Adenosine A3 Receptor (ADORA3) Antikörper

Human Adenosine A3 Receptor (ADORA3) Interaktionspartner

1. the rs1544223 polymorphism in ADORA3 was significantly associated with CHF risk under the dominant model,but it did not affect disease severity.

2. Blockade of AAR decreases the differentiation of Glioblastoma stem-like cells to endothelial cells under hypoxia and in vivo blood vessel formation.

3. Protein expression of TMIGD3 and A3AR is lower in human osteosarcoma tissues than normal tissues. Mechanistically, TMIGD3 isoform 1 and A3AR commonly inhibit the PKA-Akt-NF-kappaB axis.

4. our results demonstrated that miR-206 has a proinflammatory role in UC by downregulating A3AR expression and activating NF-kappaB signalling.

5. these findings propose that A3AR agonist induces cell cycle arrest and apoptosis in breast cancer stem cells by inhibition of ERK1/2 and GLI-1 cascade.

6. Mast cells are directly activated by contact with cancer cell membranes by a mechanism involving autocrine formation of adenosine and autocrine/paracrine signaling of the adenosine A3 receptor.

7. these data suggest that Cordyceps militaris hot water extracts containing cordycepin may be a promising treatment for bladder cancer via A3 adenosine receptor activation.

8. Differential regulation in patients with LTP-induced anaphylaxis and those with NSAID-LTP-induced anaphylaxis of the IFN-gamma pathway, IgG receptors, and ADORA3 might provide the pathogenic basis of their distinct responses

9. This study identifies human mast cell A3R as regulator of tissue remodeling gene expression in human mast cells and demonstrates a heretofore-unrecognized mode of feedback regulation that is exerted by this receptor.

10. Effect of a toggle switch mutation in TM6 of the human adenosine A receptor on Gi protein-dependent signalling and Gi-independent receptor internalization

11. This is a review of the role played by A2aR and A3AR in regulating cancer pathogenesis, with a focus on melanoma, and the therapeutic potential of adenosine receptors pharmacological modulation. [review]

12. Different agonistic behavior at adenosine A3 receptor is linked to a sub-pocket of the binding site.

13. Adenosine-A3 receptors in neutrophil microdomains promote the formation of bacteria-tethering cytonemes.

14. There is differential expression of receptors in rheumatoid synovial tissue such that ADORA3 is expressed at significantly higher levels

15. Activation of smooth muscle adenosine A(3) receptors increase proliferation of human coronary smooth cells.

16. A3Rs play a role in neutrophil migration and disrupting this function has the potential to adversely affect innate immune responses.

17. Data show that A2A and A3 adenosine receptor density inversely correlated with Disease Activity Score in 28 or 44 joints (DAS28 or DAS) suggesting a direct role of the endogenous activation of these receptors in the control of RA joint inflammation.

18. adenosine stimulates human endothelial progenitor cells migration by activating AA and A receptors and provides evidence to support a role of adenosine in modulating angiogenic capacity of hEPC

19. A3 receptor expression on the surface of PMNs is upregulated by injury, and increased expression levels are associated with greater injury severity and hypovolemic shock.

20. Inactivation of the ADORA3 receptor prevents the CXCL16 effect of neuroprotection against excitotoxic damage.

Rabbit Adenosine A3 Receptor (ADORA3) Interaktionspartner

1. Selective activation of A(1), A(2A), or A(3) adenosine receptors provides significant protection against lung ischemia-reperfusion injury.

Rhesus Monkey Adenosine A3 Receptor (ADORA3) Interaktionspartner

1. report a differential, activation state-specific expression of ADORA in microglia and uncover a role for A(3)R as dynamically regulated suppressors of A(2A)R-mediated inhibition of TLR-induced responses

Pig (Porcine) Adenosine A3 Receptor (ADORA3) Interaktionspartner

1. mRNA for adenosine A(1), A(2A), A(2B), and A(3) receptors was expressed in arterioles and venules. Protein for A(1), A(2A), and A(2B), but not A(3), was detected in both microvessel types and was further demonstrated on vascular endothelial cells

Mouse (Murine) Adenosine A3 Receptor (ADORA3) Interaktionspartner

1. Our studies show for the first time that A3R signaling plays an important role in regulating age-related osteoarthritis.

2. Reduction in nephron number combined with chronic HS intake is associated with oxidative stress, chronic inflammation, and development of hypertension in mice. Absence of adenosine A3 receptor signaling was strongly protective in this novel mouse model of renal and cardiovascular disease.

3. these data demonstrate the involvement of macrophage A3Rs in the proper chemotactic navigation and consequent in vivo clearance of apoptotic cells. Interestingly, loss of A3Rs did not affect the in vivo clearance of apoptotic thymocytes in the dexamethasone-treated thymus.

4. Adenosine A1A receptor and adenosine A3A receptor agonists and adenosine 5'-monophosphate cause regulated hypothermia that was characterized by a drop in total energy expenditure, physical inactivity, and preference for cooler environmental temperatures, indicating a reduced body temperature set point.

5. Activation of A3, A2A and A1 Adenosine Receptors in CD73-Knockout Mice Affects B16F10 Melanoma Growth, Neovascularization, Angiogenesis and Macrophage Infiltration

6. A3AR knockout mice had higher survival rates following lethal doses of gamma-radiation than wild type mice.

7. during phagocytosis of apoptotic cells the expression of A2ARs increases, while that of A3Rs decreases, on long term adenosine suppresses the proinflammatory responses in engulfing macrophages.

8. Increased values of bone marrow parameters were found in femoral bone marrow from adenosine A3 receptor-knock out mice.

9. These studies reveal A3AR activation by adenosine as an endogenous anti-nociceptive pathway and support the development of A3AR agonists as novel therapeutics to treat chronic pain.

10. The obtained data can help to define therapeutic applications based on the principle of adenosine receptor signaling.

11. Adenosin inhibited Lipopolysaccharide-increased HIF1alpha accumulation under both normoxic and hypoxic conditions, through activation of A1 and A3 adenosine receptors.

12. data show that inosine acting on A2A or A3 adenosine receptors can regulate OVA-induced allergic lung inflammation

13. A3Rs play a role in neutrophil migration and disrupting this function has the potential to adversely affect innate immune responses.

14. A3AR induces reactive oxygen species generation, possibly through activation of Nox2, with subsequent contraction of the mouse aorta.

15. A3 adenosine receptor inhibition improves the efficacy of hypertonic saline resuscitation.

16. Activation of A(1)R or A(3)R by CCPA or Cl-IB-MECA, respectively, protects cardiomyocytes from hypoxia via phosphorylation of p38 MAPK, which is located downstream from the mitochondrial K(ATP) channel opening

17. testicular mouse A3Ri2 and human A3Ri3 adenosine receptors have roles in sperm function

18. Data show that mice lacking adenosine A(3) receptors exhibit a surprisingly clear phenotype with changes in diurnal rhythm and temperature regulation.

19. Activation of macrophages by lipopolysaccharide induced down-regulation of the expression of adenosine receptor A3 mrna.

20. Hematopoietic precursor cells expressed Adora3 mrna.