HLA-DRB1 Produkte
(Major Histocompatibility Complex, Class II, DR beta 1 (HLA-DRB1))
Kategorien
HLA-DRB1 belongs to the HLA class II beta chain paralogs. The class II molecule is a heterodimer consisting of an alpha (DRA) and a beta chain (DRB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa. It is encoded by 6 exons. Exon one encodes the leader peptide\; exons 2 and 3 encode the two extracellular domains\; exon 4 encodes the transmembrane domain\; and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Hundreds of DRB1 alleles have been described and typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogs DRB3, DRB4 and DRB5. DRB1 is present in all individuals. Allelic variants of DRB1 are linked with either none or one of the genes DRB3, DRB4 and DRB5. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9. [provided by RefSeq, Jul 2008].
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Ausgewählte HLA-DRB1 Kategorien
HLA-DRB1 Antikörper
High quality antibodies with extensive validation data.
HLA-DRB1 ELISA Kits
Reliable ELISA kits for a wide range of species.
HLA-DRB1 Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene HLA-DRB1 Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Applikation
WB, IHC, IP, ICC
Validierungen
- (7)
Kat. Nr.
ABIN7440764
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Human, Monkey
Applikation
WB, FACS, IF, IHC, ISt, StM
Validierungen
- (6)
Kat. Nr.
ABIN6939640
Menge
100 μg
Datenblatt
Datenblatt
Reaktivität
Mouse
Applikation
WB, IHC, IP, ICC
Validierungen
- (5)
Kat. Nr.
ABIN7440767
Menge
100 μL
Datenblatt
Datenblatt
Empfohlene HLA-DRB1 ELISA Kits
Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (1)
Kat. Nr.
ABIN6960713
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validierungen
Kat. Nr.
ABIN6960714
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Competition ELISA
Validierungen
Kat. Nr.
ABIN2948352
Menge
96 tests
Datenblatt
Datenblatt
Empfohlene HLA-DRB1 Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
Escherichia coli (E. coli)
Validierungen
- (1)
Kat. Nr.
ABIN3087865
Menge
1 mg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Insect Cells
Validierungen
- (1)
Kat. Nr.
ABIN3088174
Menge
1 mg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Insect Cells
Validierungen
- (1)
Kat. Nr.
ABIN3112900
Menge
1 mg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren HLA-DRB1 Produkten
: "Amyotrophic lateral sclerosis, gene deregulation in the anterior horn of the spinal cord and frontal cortex area 8: implications in frontotemporal lobar degeneration." in: Aging, Vol. 9, Issue 3, pp. 823-851, (2017) (PubMed).: "DRB1*15 allele is a risk factor for PR3-ANCA disease in African Americans." in: Journal of the American Society of Nephrology : JASN, Vol. 22, Issue 6, pp. 1161-7, (2011) (PubMed).
: "Full-length sequence analysis of the HLA-DRB1 locus suggests a recent origin of alleles." in: Immunogenetics, Vol. 59, Issue 4, pp. 261-71, (2007) (PubMed).
: "Ancient haplotypes of the HLA Class II region." in: Genome research, Vol. 15, Issue 9, pp. 1250-7, (2005) (PubMed).
: "Evolution of the HLA-DR1 gene family. Structural and functional analysis of the new allele "DR-BON"." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 144, Issue 3, pp. 984-9, (1990) (PubMed).
: "DNA sequence and characterization of human class II major histocompatibility complex beta chains from the DR1 haplotype." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 82, Issue 10, pp. 3405-9, (1985) (PubMed).
Synonyme und alternative Namen zu HLA-DRB1
major histocompatibility complex, class II, DR beta 1 (hla-drb1), major histocompatibility complex, class II, DR beta 1 (HLA-DRB1), DRB1, DRw10, HLA-DR1B, HLA-DRB, MGC108235, SS1Bezeichner auf Proteinebene für HLA-DRB1
- major histocompatibility complex, class II, DR beta 1
- DW2.2/DR2.2
- HLA class II histocompatibility antigen, DR-1 beta chain
- MHC class II HLA-DR beta 1 chain
- MHC class II HLA-DR-beta cell surface glycoprotein
- MHC class II HLA-DRw10-beta
- MHC class II antigen
- human leucocyte antigen DRB1
- lymphocyte antigen DRB1
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