HLA-B Produkte
(Major Histocompatibility Complex, Class I, B (HLA-B))
Kategorien
HLA-B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exon 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-B alleles have been described. [provided by RefSeq, Jul 2008].
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Ausgewählte HLA-B Kategorien
HLA-B Antikörper
High quality antibodies with extensive validation data.
HLA-B ELISA Kits
Reliable ELISA kits for a wide range of species.
HLA-B Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene HLA-B Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Applikation
WB, IHC (p)
Validierungen
- (5)
- (6)
Kat. Nr.
ABIN1944779
Menge
400 μL
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB, IHC, IP, ICC
Validierungen
- (7)
Kat. Nr.
ABIN7440755
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB, ELISA, IHC, IF
Validierungen
- (3)
Kat. Nr.
ABIN7155621
Menge
100 μg
Datenblatt
Datenblatt
Empfohlene HLA-B ELISA Kits
Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (1)
Kat. Nr.
ABIN6957622
Menge
96 tests
Datenblatt
Datenblatt
Empfohlene HLA-B Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
Escherichia coli (E. coli)
Validierungen
- (1)
Kat. Nr.
ABIN7123829
Menge
50 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Escherichia coli (E. coli)
Validierungen
Kat. Nr.
ABIN7577416
Menge
100 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Escherichia coli (E. coli)
Validierungen
Kat. Nr.
ABIN7412851
Menge
100 μg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren HLA-B Produkten
: "Immunogenic peptides putatively from intratumor microbes: Opportunities for colorectal cancer treatment." in: iScience, Vol. 27, Issue 12, pp. 111338, (2024) (PubMed).: "A viral, transporter associated with antigen processing (TAP)-independent, high affinity ligand with alternative interactions endogenously presented by the nonclassical human leukocyte antigen E ..." in: The Journal of biological chemistry, Vol. 287, Issue 42, pp. 34895-903, (2012) (PubMed).
: "Allele-dependent processing pathways generate the endogenous human leukocyte antigen (HLA) class I peptide repertoire in transporters associated with antigen processing (TAP)-deficient cells." in: The Journal of biological chemistry, Vol. 286, Issue 44, pp. 38054-9, (2011) (PubMed).
: "Multiple viral ligands naturally presented by different class I molecules in transporter antigen processing-deficient vaccinia virus-infected cells." in: Journal of virology, Vol. 86, Issue 1, pp. 527-41, (2011) (PubMed).
: "Further molecular diversity in the HLA-B15 group." in: Tissue antigens, Vol. 47, Issue 4, pp. 265-74, (1996) (PubMed).
: "HLA-B15: a widespread and diverse family of HLA-B alleles." in: Tissue antigens, Vol. 43, Issue 4, pp. 209-18, (1994) (PubMed).
: "The HLA-Bw75 subtype of B15: molecular characterization and comparison with crossreacting antigens." in: Tissue antigens, Vol. 38, Issue 4, pp. 186-90, (1992) (PubMed).
: "Distinctive HLA-A,B antigens of black populations formed by interallelic conversion." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 149, Issue 10, pp. 3411-5, (1992) (PubMed).
: "New recombinant HLA-B alleles in a tribe of South American Amerindians indicate rapid evolution of MHC class I loci." in: Nature, Vol. 357, Issue 6376, pp. 329-33, (1992) (PubMed).
Synonyme und alternative Namen zu HLA-B
major histocompatibility complex, class I, B (HLA-B), major histocompatibility complex, class I, B (BOLA-B), major histocompatibility complex, class I, B (MAMU-B18), major histocompatibility complex, class I, B (DKFZP469N1225), major histocompatibility complex nonclassical class Ib L homeolog (mhc1b.L), AS, HLAB, mhc1b, SPDA1Bezeichner auf Proteinebene für HLA-B
- HLA class I histocompatibility antigen, B alpha chain
- MHC Class I HLA heavy chain
- MHC HLA-B cell surface glycoprotein
- MHC HLA-B transmembrane glycoprotein
- MHC class I antigen GN00104
- MHC class I antigen HLA-B heavy chain
- MHC class I antigen SHCHA
- leukocyte antigen class I-B
- lymphocyte antigen
- major histocompatibility complex, class I, B
- major histocompatibility complex nonclassical class Ib L homeolog
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