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anti-Rat (Rattus) OAS1 Antikörper:
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Human Polyclonal OAS1 Primary Antibody für IHC (p), WB - ABIN390164
Gielen, Johnston, Edwards: Azithromycin induces anti-viral responses in bronchial epithelial cells. in The European respiratory journal 2010
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Cow (Bovine) Polyclonal OAS1 Primary Antibody für IHC, WB - ABIN2773987
Phosri, Martín, Sihanonth, Whalley, Watling: Molecular study of the genus Astraeus. in Mycological research 2007
Show all 3 Pubmed References
Cow (Bovine) Polyclonal OAS1 Primary Antibody für IHC, WB - ABIN2778801
Lazrek, Goffard, Schanen, Karquel, Bocket, Lion, Devaux, Hedouin, Gosset, Hober: Detection of hepatitis C virus antibodies and RNA among medicolegal autopsy cases in Northern France. in Diagnostic microbiology and infectious disease 2006
Show all 2 Pubmed References
Human Polyclonal OAS1 Primary Antibody für IHC, WB - ABIN2779349
Li, Tainsky: Higher miRNA tolerance in immortal Li-Fraumeni fibroblasts with abrogated interferon signaling pathway. in Cancer research 2011
Data indicate that the expression profiles of ISG15 (zeige ISG15 Antikörper), MX1 (zeige MX1 Antikörper), MX2 (zeige MX2 Antikörper), and OAS1 could be a useful diagnostic biomarker of gestation.
Studied diversity of OAS1 in hominoids (focus on chimpanzees) and found the OAS1 gene extremely polymorphic in Central African chimpanzee and exhibits levels of silent and replacement diversity much higher than neutral regions of the chimpanzee genome.
This study describes methylation patterns of CpG islands around the equine OAS1 locus in which polymorphic variants are associated with susceptibility to WNV infections
Mutations in equine OAS1 contribute to host susceptibility to West Nile encephalitis.
Oas1b is part of a complex located in the ER and that ABCF3 is a component of the Flv(r)-mediated resistance mechanism.
Activation of Oas1b gene expression by type I IFN requires only STAT2 (zeige STAT2 Antikörper), not STAT1 (zeige STAT1 Antikörper).
Oas1b inhibits flavivirus replication by an alternative mechanism that overrides the proviral effect of reducing 2-5A accumulation and RNase L (zeige RNASEL Antikörper) activation.
A positional cloning strategy was used to identify 22 genes from the Flv gene interval including 10 members of the 2'-5'-oligoadenylate synthetase gene family.
OAS1 rs2057778) genotype was significantly related to severe necroinflammatory activity (NIA) grade of chronic hepatitis C patients.
Our results establish OAS1 as a risk locus for Sjogren's syndrome and support a potential role for defective viral clearance due to altered IFN response as a genetic pathophysiological basis of this complex autoimmune disease
we characterized the functional consequences of the Neandertal haplotype in the transcriptional regulation of OAS (zeige SMOC1 Antikörper) genes at baseline and infected conditions. We found that cells from people with the Neandertal-like haplotype express lower levels of OAS3 (zeige OAS3 Antikörper) upon infection, as well as distinct isoforms of OAS1 and OAS2 (zeige OAS2 Antikörper)
In insulitic islets from living patients with recent-onset T1D, most of the overexpressed ISGs, including GBP1 (zeige GBP1 Antikörper), TLR3 (zeige TLR3 Antikörper), OAS1, EIF2AK2 (zeige EIF2AK2 Antikörper), HLA-E (zeige HLAE Antikörper), IFI6 (zeige IFI6 Antikörper), and STAT1 (zeige STAT1 Antikörper), showed higher expression in the islet core compared with the peri (zeige PLIN1 Antikörper)-islet area containing the surrounding immune cells
ELF-1 (zeige EFNA2 Antikörper) binds an important duplicated GGAA cis (zeige CISH Antikörper)-acting element at the OAS1 promoter and in cooperation with RB1 (zeige RB1 Antikörper) and SP1 (zeige PSG1 Antikörper) recruitment contributes to regulation in response to IFN stimulation.
Knockdown of OAS1 rescues Lipopolysaccharide-induced cell death and thus may be a promising therapeutic strategy for orthopedic diseases.
The multivariate analysis showed that the OAS1 GA and AA genotypes were independent factors associated with liver fibrosis progression (p = 0.009, odds ratio [OR] 3.467, 95% confidence interval [CI] 1.273-7.584).
Preliminary study suggests that OAS (zeige SMOC1 Antikörper) gene cluster and CD209 (zeige CD209 Antikörper) gene polymorphisms influence the risk of developing clinical symptoms in Chikungunya virus-infected patients.
While both OAS1-p42 (zeige EPB42 Antikörper) and p46 (zeige POLDIP3 Antikörper) showed antiviral activity against Dengue irus 2, only OAS1-p42 (zeige EPB42 Antikörper) presented anti-Dengue irus 1 activity.
No association is identified between OAS1 SNP and susceptibility to spontaneous preterm birth (SPTB (zeige SPTB Antikörper)) and preterm premature rupture of membranes (PPROM (zeige SERPINH1 Antikörper)).
Comparison of day 25 Meishan and white composite swine placentas by microarray expression profiling revealed a breed-specific transition expression polymorphism in OAS1.
The active sites of OAS (zeige SMOC1 Antikörper) and CCA (zeige FBN2 Antikörper) class I enzymes are highly conserved.
This gene encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. The encoded protein is induced by interferons and uses adenosine triphosphate in 2'-specific nucleotidyl transfer reactions to synthesize 2',5'-oligoadenylates (2-5As). These molecules activate latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. The three known members of this gene family are located in a cluster on chromosome 12. Mutations in this gene have been associated with host susceptibility to viral infection. Alternatively spliced transcript variants encoding different isoforms have been described.
2',5'-oligoadenylate synthetase 1, 40/46kDa
, 2'-5'-oligoadenylate synthase 1
, 2'-5'-oligoadenylate synthetase 1
, 2'-5' oligoadenylate synthetase 1
, 2',5'-oligoadenylate synthetase 1
, 2'-5'-oligoadenylate synthetase 1-like
, 2'-5'-oligoadenylate synthetase 1, 40/46kDa
, (2-5')oligo(A) synthase 1
, (2-5')oligo(A) synthase 1A
, (2-5')oligo(A) synthetase 1
, 2'-5' oligoadenylate synthetase 1G
, 2'-5'-oligoadenylate synthase 1A
, 2-5A synthase 1
, 2-5A synthase 1A
, 2-5A synthetase 1
, 25 oligoadenylate synthetase
, (2-5')oligo(A) synthase 1B
, (2-5')oligo(A) synthetase 1b
, 2',5'-oligoadenylate synthetase-like 1
, 2'-5'-oligoadenylate synthase 1B
, 2'-5'-oligoadenylate synthase-like protein 1
, 2'-5'-oligoadenylate synthetase-like protein 1
, 2-5A synthase 1B
, 2-5A synthetase 1B
, Flavivirus resistance
, inactive 2'-5'-oligoadenylate synthase 1B
, 2',5'-oligo A synthetase 1
, 2'-5' oligoadenylate synthetase 1 p48 isoform
, 2'-5' oligoadenylate synthetase 1 p52 isoform
, 2'-5'-oligoisoadenylate synthetase 1
, p46/p42 OAS
, 2-5-oligoadenylate synthetase 1
, 2'-5' oligoadenylate synthetase
, p42 OAS
, 2'-5' oligoadenylate synthetase 1z