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GCH1 Proteine

(GTP Cyclohydrolase 1 (GCH1))

This gene encodes a member of the GTP cyclohydrolase family. The encoded protein is the first and rate-limiting enzyme in tetrahydrobiopterin (BH4) biosynthesis, catalyzing the conversion of GTP into 7,8-dihydroneopterin triphosphate. BH4 is an essential cofactor required by aromatic amino acid hydroxylases as well as nitric oxide synthases. Mutations in this gene are associated with malignant hyperphenylalaninemia and dopa-responsive dystonia. Several alternatively spliced transcript variants encoding different isoforms have been described\; however, not all variants give rise to a functional enzyme. [provided by RefSeq, Jul 2008].

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GCH1 Protein (AA 1-250) (His tag)

custom-made GCH1 Spezies: Human Wirt: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)

AlphaFold protein structure predicition of Human Recombinant GCH1 Protein, UniprotID P30793

3 Abbildungen

Produktnummer ABIN7547848

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GCH1 Protein (AA 1-250) (GST tag)

GCH1 Spezies: Human Wirt: Wheat germ Recombinant WB, ELISA, AA, AP

Image no. 1 for GTP Cyclohydrolase 1 (GCH1) (AA 1-250) protein (GST tag) (ABIN1354910)

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1 reference

Produktnummer ABIN1354910

Details

GCH1 Protein (AA 16-250) (His tag)

GCH1 Spezies: Human Wirt: Escherichia coli (E. coli) Recombinant > 97 % WB, PC, SDS, Imm

Produktnummer ABIN7422661

Details

GCH1 Protein (AA 1-250) (Strep Tag)

custom-made GCH1 Spezies: Human Wirt: Cell-free protein synthesis (CFPS) Recombinant approximately 70-80 % as determined by SDS PAGE, Western Blot and analytical SEC (HPLC). WB, ELISA, SDS

Produktnummer ABIN3080453