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FGFR2 Produkte

(Fibroblast Growth Factor Receptor 2 (FGFR2))

Kategorien

The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member is a high-affinity receptor for acidic, basic and/or keratinocyte growth factor, depending on the isoform. Mutations in this gene are associated with Crouzon syndrome, Pfeiffer syndrome, Craniosynostosis, Apert syndrome, Jackson-Weiss syndrome, Beare-Stevenson cutis gyrata syndrome, Saethre-Chotzen syndrome, and syndromic craniosynostosis. Multiple alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jan 2009].

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Ausgewählte FGFR2 Kategorien

FGFR2 Antikörper

High quality antibodies with extensive validation data.

FGFR2 ELISA Kits

Reliable ELISA kits for a wide range of species.

FGFR2 Proteine

Proteins for various applications incl. WB, ELISA, IF etc.

Empfohlene FGFR2 Antikörper

Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human, Mouse
Applikation WB, FACS, IF, IHC (p)
Validierungen
  • (5)
  • (7)
Kat. Nr. ABIN391965
Menge 400 μL
Datenblatt Datenblatt
Reaktivität Human
Applikation IHC
Validierungen
  • (7)
Kat. Nr. ABIN3022855
Menge 100 μL
Datenblatt Datenblatt
Reaktivität Human
Applikation WB, FACS, IF, IHC (p)
Validierungen
  • (5)
Kat. Nr. ABIN391968
Menge 400 μL
Datenblatt Datenblatt

Empfohlene FGFR2 ELISA Kits

Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Analytical Method Quantitative Sandwich ELISA
Validierungen
  • (1)
Kat. Nr. ABIN6955878
Menge 96 tests
Datenblatt Datenblatt
Reaktivität Human, Mouse, Rat
Analytical Method Qualitative Cell ELISA
Validierungen
Kat. Nr. ABIN1381135
Menge 96 tests
Datenblatt Datenblatt
Reaktivität Human
Analytical Method Semi-Quantitative Sandwich ELISA
Validierungen
Kat. Nr. ABIN4886102
Menge 96 tests
Datenblatt Datenblatt

Empfohlene FGFR2 Proteine

Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Source Insect cells (Sf21)
Validierungen
  • (2)
Kat. Nr. ABIN5570009
Menge 5 μg
Datenblatt Datenblatt
Reaktivität Human
Source Insect cells (Sf21)
Validierungen
  • (2)
Kat. Nr. ABIN5570166
Menge 5 μg
Datenblatt Datenblatt
Reaktivität Human
Source Wheat germ
Validierungen
  • (1)
Kat. Nr. ABIN1354041
Menge 10 μg
Datenblatt Datenblatt

Neueste Publikationen zu unseren FGFR2 Produkten

Di Liddo, Bertalot, Borean, Pirola, Argentoni, Schrenk, Cenzi, Capelli, Conconi, Parnigotto: "Leucocyte and Platelet-rich Fibrin: a carrier of autologous multipotent cells for regenerative medicine." in: Journal of cellular and molecular medicine, Vol. 22, Issue 3, pp. 1840-1854, (2018) (PubMed).

Zhou, He, Pang, Appelman, Kuick, Beer, Li, Wang: "Identification and validation of FGFR2 peptide for detection of early Barrett's neoplasia." in: Oncotarget, Vol. 8, Issue 50, pp. 87095-87106, (2017) (PubMed).

Czaplinska, Mieczkowski, Supernat, Skladanowski, Kordek, Biernat, Zaczek, Romanska, Sadej: "Interactions between FGFR2 and RSK2-implications for breast cancer prognosis." in: Tumour biology, Vol. 37, Issue 10, pp. 13721-13731, (2016) (PubMed).

Guan, Gao, Zhou, Wang, Zheng, Guo, Chang, Li, Wang: "miR-223 Regulates Adipogenic and Osteogenic Differentiation of Mesenchymal Stem Cells Through a C/EBPs/miR-223/FGFR2 Regulatory Feedback Loop." in: Stem cells (Dayton, Ohio), Vol. 33, Issue 5, pp. 1589-600, (2015) (PubMed).

Katano, Yamada: "Upregulation of ANGPTL4 messenger RNA and protein in severely calcified carotid plaques." in: Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, Vol. 23, Issue 5, pp. 933-47, (2014) (PubMed).

Lee, Seo, Park, Kim, Park, Yu, Ahn, Gong: "Low prognostic implication of fibroblast growth factor family activation in triple-negative breast cancer subsets." in: Annals of surgical oncology, Vol. 21, Issue 5, pp. 1561-8, (2014) (PubMed).

Cazet, Charest, Bennett, Sambrooks, Contessa: "Mannose phosphate isomerase regulates fibroblast growth factor receptor family signaling and glioma radiosensitivity." in: PLoS ONE, Vol. 9, Issue 10, pp. e110345, (2014) (PubMed).

Grygielewicz, Dymek, Bujak, Gunerka, Stanczak, Lamparska-Przybysz, Wieczorek, Dzwonek, Zdzalik: "Epithelial-mesenchymal transition confers resistance to selective FGFR inhibitors in SNU-16 gastric cancer cells." in: Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association, (2014) (PubMed).

Tchaicha, Akbay, Altabef, Mikse, Kikuchi, Rhee, Liao, Bronson, Sholl, Meyerson, Hammerman, Wong: "Kinase domain activation of FGFR2 yields high-grade lung adenocarcinoma sensitive to a Pan-FGFR inhibitor in a mouse model of NSCLC." in: Cancer research, Vol. 74, Issue 17, pp. 4676-84, (2014) (PubMed).

Ozawa, Yang, Ealy: "The expression of fibroblast growth factor receptors during early bovine conceptus development and pharmacological analysis of their actions on trophoblast growth in vitro." in: Reproduction (Cambridge, England), Vol. 145, Issue 2, pp. 191-201, (2013) (PubMed).

Synonyme und alternative Namen zu FGFR2

fibroblast growth factor receptor 2 (FGFR2), fibroblast growth factor receptor 2 (LOC100084641), fibroblast growth factor receptor 2 (fgfr2), fibroblast growth factor receptor 2 (Fgfr2), fibroblast growth factor receptor 2 L homeolog (fgfr2.L), AU043015, AW556123, BBDS, bek, BEK, Bek, bfr-1, BFR-1, cd332, CD332, cek3, CEK3, cfd1, CFD1, DKFZp469H1521, ect1, ECT1, fc56c05, FGF-R, FGFR, fgfr-2, Fgfr-2, Fgfr-7, FGFR2, FGFR2IIIb, Fgfr7, fgfr72IIIb, jws, JWS, k-sam, K-SAM, kgfr, KGFR, KGFRTr, svs, tk14, TK14, tk25, TK25, wu:fc56c05, xfgfr2

Bezeichner auf Proteinebene für FGFR2

  • fibroblast growth factor receptor 2
  • bacteria-expressed kinase
  • keratinocyte growth factor receptor
  • fibroblast growth factor receptor 2 IIIb
  • fibroblast growth factor receptor 2 (bacteria-expressed kinase, keratinocyte growth factor receptor, craniofacial dysostosis 1, Crouzon syndrome, Pfeiffer syndrome, Jackson-Weiss syndrome)
  • BEK fibroblast growth factor receptor
  • FGF receptor
  • FGFR-2
  • hydroxyaryl-protein kinase
  • protein tyrosine kinase, receptor like 14
  • soluble FGFR4 variant 4
  • FGF-7 receptor 2IIIb
  • fgf receptor
  • chicken tyrosine kinase (cek3)
  • receptor tyrosine kinase
  • tyrosine kinase receptor CEK3
  • fibroblast growth factor receptor-2
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