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anti-Human NRF2 Antikörper:
anti-Mouse (Murine) NRF2 Antikörper:
anti-Rat (Rattus) NRF2 Antikörper:
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Human Polyclonal NRF2 Primary Antibody für IF (p), IHC (p) - ABIN737271
Lee, Hsu, Chang, Kuo, Hsu, Pan: Ankaflavin: a natural novel PPAR? agonist upregulates Nrf2 to attenuate methylglyoxal-induced diabetes in vivo. in Free radical biology & medicine 2012
Show all 19 Pubmed References
Human Polyclonal NRF2 Primary Antibody für IHC (fro), IF (p) - ABIN676673
Lee, Hsu, Hsu, Pan: Dimerumic acid attenuates receptor for advanced glycation endproducts signal to inhibit inflammation and diabetes mediated by Nrf2 activation and promotes methylglyoxal metabolism into d-lactic acid. in Free radical biology & medicine 2013
Show all 17 Pubmed References
Human Polyclonal NRF2 Primary Antibody für ChIP, ICC - ABIN442777
Sullivan, Martinez-Garcia, Nguyen, Mullen, Dufour, Sudarshan, Licht, Deberardinis, Chandel: The proto-oncometabolite fumarate binds glutathione to amplify ROS-dependent signaling. in Molecular cell 2013
Show all 4 Pubmed References
Human Polyclonal NRF2 Primary Antibody für IHC, IHC (p) - ABIN4340688
Suchocki, Misiewicz-Krzemińska, Skupińska, Niedźwiecka, Lubelska, Fijałek, Kasprzycka-Guttman: Selenitetriglicerydes affect CYP1A1 and QR activity by involvement of reactive oxygen species and Nrf2 transcription factor. in Pharmacological reports : PR 2010
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Human Polyclonal NRF2 Primary Antibody für IHC, ELISA - ABIN1584873
Bagul, Middela, Matapally, Padiya, Bastia, Madhusudana, Reddy, Chakravarty, Banerjee: Attenuation of insulin resistance, metabolic syndrome and hepatic oxidative stress by resveratrol in fructose-fed rats. in Pharmacological research : the official journal of the Italian Pharmacological Society 2012
Show all 2 Pubmed References
Human Polyclonal NRF2 Primary Antibody für IHC (p), WB - ABIN3043888
Wang, Du, Duan, Guo, Sun, Liu: Inhibiting heme oxygenase-1 attenuates rat liver fibrosis by removing iron accumulation. in World journal of gastroenterology : WJG 2013
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Human Polyclonal NRF2 Primary Antibody für ICC, IHC (p) - ABIN3044196
Li, Xie, Chen, Wang, Yu: Hydrogen gas inhibits high-mobility group box 1 release in septic mice by upregulation of heme oxygenase 1. in The Journal of surgical research 2015
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Human Monoclonal NRF2 Primary Antibody für IF, ELISA - ABIN518315
Lindl, Jordan-Sciutto: Examining the endogenous antioxidant response through immunofluorescent analysis of Nrf2 in tissue. in Methods in molecular biology (Clifton, N.J.) 2008
Human Monoclonal NRF2 Primary Antibody für IHC, ELISA - ABIN1724931
Sandford, Malhotra, Boezen, Siedlinski, Postma, Wong, Akhabir, He, Connett, Anthonisen, Paré, Biswal: NFE2L2 pathway polymorphisms and lung function decline in chronic obstructive pulmonary disease. in Physiological genomics 2012
Rat (Rattus) Polyclonal NRF2 Primary Antibody für ICC, IHC - ABIN1869445
Baluchnejadmojarad, Zeinali, Roghani: Scutellarin alleviates lipopolysaccharide-induced cognitive deficits in the rat: Insights into underlying mechanisms. in International immunopharmacology 2017
These results suggest that alpha,beta-unsaturated carbonyl entity and catechol moiety of 6S derivatives may react with the cysteine residues of Keap1 (zeige KEAP1 Antikörper), disrupting the Keap1 (zeige KEAP1 Antikörper)-Nrf2 complex, thereby liberating and activating Nrf2. Our findings of natural product-derived Nrf2 activators lead to design options of potent Nrf2 activators for further optimization.
These data suggest that EC from the Tripterygium wilfordii stem extract could diminish tau-GFP-induced neuronal death through the activation of Nrf2.
we concluded that Nrf2 plays a fundamental and conserved role in protection against acute sodium arsenite toxicity
Coptisine exerted its antioxidant activity against AAPH-induced toxicity involving in activating Akt (zeige AKT1 Antikörper) and JNK (zeige MAPK8 Antikörper)/Nrf2/NQO1 (zeige NQO1 Antikörper) pathway.
Bach1 (zeige BACH1 Antikörper) regulates the liver specificity and transience of the Nrf2a-dependent induction of hmox1a and that heme mediates this regulation through Bach1 (zeige BACH1 Antikörper) inhibition based on its level in each tissue.
The Bach1b-MafK heterodimer represses the zymogen promoters, whereas the Nrf2a-MafK heterodimer activates them.
The expression of nrf genes varies temporally throughout development and nrf genes are induced following a pro-oxidant exposure and are potentially cross-regulated by gene family members Nrf2a and Nrf2b.
oxidative stress is an important mechanism of Cd-mediated injury in the zebrafish olfactory system; the Nrf2 pathway plays a protective role against cellular oxidative damage and is important in maintaining zebrafish olfactory function.
results revealed that nrf2 mutant zebrafish are viable and fertile but show an increased susceptibility to oxidative stress and electrophiles
compared the tissue-specific expression of several Nrf2 target genes in zebrafish larvae; Tissue-restricted induction was observed in the nose, gill, and/or liver for seven genes in response to Nrf2-activating compounds
These findings suggest that bronchiolar epithelial cells and macrophages up-regulate Nrf2 expression early in the course of infection, which results in increased expression of HO-1 (zeige HMOX1 Antikörper) within these cells.
the survival and developmental competence of embryos cultured under oxidative stress are associated with activity of the NRF2-mediated oxidative stress response pathway during bovine pre-implantation embryo development.
investigation of molecular mechanisms of microvascular complications in diabetes/hyperglycemia: Nrf2 is involved in regulation of HO-1 (zeige HMOX1 Antikörper) gene expression in aortic endothelial cells by advanced glycation end products
Lack of Nrf2 enhances susceptibility to mycotoxin-induced kidney disease.
The effects of ochratoxin A on the nuclear translocation and transactivation of the transcription factor Nrf2 as well as mRNA levels of Nrf2 target genes are reported.
MRTF-A (zeige MKL1 Antikörper) regulated the transcriptional activity of Nrf2 (zeige GABPA Antikörper) by forming a complex with SRF binding to the CarG box which existed on Nrf2 (zeige GABPA Antikörper) promoter region, increasing the resistance of tumor cells to doxorubicin.
Nrf2 (zeige GABPA Antikörper) inhibitors induces growth inhibition and apoptosis of acute myeloid leukemia (zeige BCL11A Antikörper) cells.
Authors showed that upon TMZ treatment there is an induction of the nuclear factor erythroid 2-related factor 2 (NRF2), which is the main antioxidant transcription factor regulator in human cells.
This is the first study to demonstrate that house dust mite antigen-induced sinonasal epithelial cell barrier dysfunction may be preventable by Nrf2 (zeige GABPA Antikörper) activation. The Nrf2 (zeige GABPA Antikörper) antioxidant pathway may represent a potential therapeutic target for allergen-induced sinonasal inflammation.
Vaginal cell-derived Hb-alpha and Hb-beta may have antioxidative properties and protect cells from oxidative stress-induced (zeige SQSTM1 Antikörper) inflammation possibly through Nrf2 (zeige GABPA Antikörper) downstream signaling.
this study demonstrated that Nrf2 (zeige GABPA Antikörper) was significantly elevated in hepatocellular carcinoma cells and tissues and was correlated with poor prognosis
Nrf2 (zeige GABPA Antikörper) suppresses prostate cancer cells viability, migration, and mitosis by upregulating ferroportin (zeige SLC40A1 Antikörper) expression.
summary, we identified a novel signaling axis involving MALAT1, Keap1 (zeige KEAP1 Antikörper) and Nrf2 (zeige GABPA Antikörper), which in turn protects HUVECs from oxidative injury.
The asymmetrical activation of NFE2L2 in placental shares of sIUGR twins may be a compensation for hypoxia that protects the smaller fetus from oxidative stress damage.
the G allele, GG, and GA genotype of the NFE2L2 rs35652124 (A/G) polymorphism were not associated with the risk of Parkinson's disease (Meta-Analysis)
The in vitro study illustrated that the anti-inflammatory effects of RA-XII were partially reversed following Nrf2 and HO-1 (zeige HMOX1 Antikörper) inhibition. Together, these findings strongly suggested that RA-XII is a potential agent against acute kidney injury.
It is a key transcription factor regulating HO-1 (zeige HMOX1 Antikörper) induction.
Nrf2-mediated stimulation of intrarenal Renin (zeige REN Antikörper)-Angiotensin system gene expression, by which chronic hyperglycemia induces hypertension and renal injury in diabetes.
Studied role of nuclear factor (NF)-E2-related factor-2 (Nrf2) and NF-kappaB (zeige NFKB1 Antikörper) in inflammation and apoptosis induced by intestinal ischemia-reperfusion (IIR) in mice; findings indicate a critical role in IIR for Nrf2, possibly thru inhibition of NF-kappaB (zeige NFKB1 Antikörper) pathway.
The p62 (zeige GTF2H1 Antikörper)-keap1 (zeige KEAP1 Antikörper)-Nrf2 antioxidant pathway was primarily activated in the early stage of APAP hepatotoxicity.
Genetic activation of the antioxidant transcription factor Nrf2 improves liver damage and repair in hepatocyte-specific c-met-deficient mice mainly through restoring a balance in the cellular redox homeostasis.
is the first study to report that genetic ablation of Nrf2 exacerbates visual deficits, inflammation of the optic nerve, and RGC degeneration in a murine model of multiple sclerosis.
YZH-106 induced p38 MAPK (zeige MAPK14 Antikörper) and ERK1/2 phosphorylation, which led to the activation of erythroid 2-related factor 2 (Nrf2) that up-regulated heme oxygenase-1 (HO-1 (zeige HMOX1 Antikörper)) expression in addition to other genes.
Ltbp4 (zeige LTBP4 Antikörper) regulates Pdgfrb (zeige PDGFRB Antikörper) expression via TGFbeta (zeige TGFB1 Antikörper)-dependent modulation of Nrf2 transcription factor function.
a new role for nuclear factor erythroid-derived 2-like 2 (Nrf2) in regulating early anti-cancer immune responses by inducing IL-17D (zeige IL17D Antikörper) and recruiting natural killer (NK) cells.
This gene encodes a transcription factor which is a member of a small family of basic leucine zipper (bZIP) proteins. The encoded transcription factor regulates genes which contain antioxidant response elements (ARE) in their promoters\; many of these genes encode proteins involved in response to injury and inflammation which includes the production of free radicals. Multiple transcript variants encoding different isoforms have been found for this gene.
, nuclear factor (erythroid-derived 2)-like 2
, nuclear factor erythroid 2-related factor 2
, NF-E2-related factor 2
, NFE2-related factor 2
, nuclear factor, erythroid derived 2, like 2
, nuclear factor erythroid-derived 2-like 2
, nuclear factor erythroid 2-like 2