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NRF2 Antikörper (Internal Region)

NFE2L2 Reaktivität: Human, Ratte WB, IF, ICC, IP, IHC (p), ChIP Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN2855612
  • Target Alle NRF2 (NFE2L2) Antikörper anzeigen
    NRF2 (NFE2L2) (Nuclear Factor (erythroid-Derived 2)-Like 2 (NFE2L2))
    Bindungsspezifität
    • 22
    • 15
    • 9
    • 8
    • 8
    • 7
    • 7
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Internal Region
    Reaktivität
    • 120
    • 57
    • 54
    • 5
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Ratte
    Wirt
    • 113
    • 9
    • 1
    Kaninchen
    Klonalität
    • 104
    • 19
    Polyklonal
    Konjugat
    • 58
    • 10
    • 7
    • 6
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser NRF2 Antikörper ist unkonjugiert
    Applikation
    • 96
    • 52
    • 31
    • 29
    • 20
    • 18
    • 15
    • 14
    • 14
    • 9
    • 7
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Chromatin Immunoprecipitation (ChIP)
    Produktmerkmale
    Rabbit Polyclonal antibody to NRF2 (nuclear factor (erythroid-derived 2)-like 2)
    NRF2 antibody [N2C2], Internal
    Aufreinigung
    Purified by antigen-affinity chromatography.
    Immunogen
    Recombinant protein encompassing a sequence within the center region of human NRF2. The exact sequence is proprietary.
    Isotyp
    IgG
    Top Product
    Discover our top product NFE2L2 Primärantikörper
  • Applikationshinweise
    Suggested dilution Reference ChIP assay Assay-dependent dilution ICC/IF 1:100-1:1000* IHC (Formalin-fixed paraffin-embedded sections) 1:100-1:1000* Immunoprecipitation 1:100-1:500* Western blot 1:500-1:3000* Not tested in other applications. *Optimal dilutions/concentrations should be determined by the researcher.Suggested dilutionReferenceChIP assayAssay-dependent dilution ICC/IF1:100-1:1000* IHC (Formalin-fixed paraffin-embedded sections)1:100-1:1000* Immunoprecipitation1:100-1:500* Western blot1:500-1:3000*
    Kommentare

    Positive Control: MDA-MB-231 NE , MDA-MB-231 NE treated tBHQ , 3xFlag-human NFE2L2-transfected 293T

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    0.51 mg/mL
    Buffer
    1XPBS, 20 % Glycerol ( pH 7). 0.025 % ProClin 300 was added as a preservative.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
  • Tsai, Chen, Lin, Chou, Chen, Ho, Lin, Hwang: "Miconazole Contributes to NRF2 Activation by Noncanonical P62-KEAP1 Pathway in Bladder Cancer Cells." in: Drug design, development and therapy, Vol. 14, pp. 1209-1218, (2020) (PubMed).

    Batubara, Astuti, Prastya, Ilmiawati, Maeda, Suzuki, Hamamoto, Takemori: "The Antiaging Effect of Active Fractions and Ent-11α-Hydroxy-15-Oxo-Kaur-16-En-19-Oic Acid Isolated from Adenostemma lavenia (L.) O. Kuntze at the Cellular Level." in: Antioxidants (Basel, Switzerland), Vol. 9, Issue 8, (2020) (PubMed).

    Chou, Lin, Dzhagalov, Chen, Lin, Lin, Chen, Chen, Fu: "Vaccine adjuvant activity of a TLR4-activating synthetic glycolipid by promoting autophagy." in: Scientific reports, Vol. 10, Issue 1, pp. 8422, (2020) (PubMed).

    Neitzel, Seiwert, Göder, Diehl, Weber, Nagel, Stroh, Rasenberger, Christmann, Fahrer: "Lipoic Acid Synergizes with Antineoplastic Drugs in Colorectal Cancer by Targeting p53 for Proteasomal Degradation." in: Cells, Vol. 8, Issue 8, (2020) (PubMed).

    Luo, Shang, Brooks, Jiagge, Zhu, Buschhaus, Conley, Fath, Davis, Gheordunescu, Wang, Harouaka, Lozier, Triner, McDermott, Merajver, Luker, Spitz, Wicha: "Targeting Breast Cancer Stem Cell State Equilibrium through Modulation of Redox Signaling." in: Cell metabolism, Vol. 28, Issue 1, pp. 69-86.e6, (2019) (PubMed).

    García Trejo, Arellano Buendía, Sánchez Reyes, García Arroyo, Arguello García, Loredo Mendoza, Tapia, Sánchez Lozada, Osorio Alonso: "The Beneficial Effects of Allicin in Chronic Kidney Disease Are Comparable to Losartan." in: International journal of molecular sciences, Vol. 18, Issue 9, (2018) (PubMed).

    Fragoulis, Siegl, Fendt, Jansen, Soppa, Brandenburg, Pufe, Weis, Wruck: "Oral administration of methysticin improves cognitive deficits in a mouse model of Alzheimer's disease." in: Redox biology, Vol. 12, pp. 843-853, (2018) (PubMed).

    García-Trejo, Arellano-Buendía, Argüello-García, Loredo-Mendoza, García-Arroyo, Arellano-Mendoza, Castillo-Hernández, Guevara-Balcázar, Tapia, Sánchez-Lozada, Osorio-Alonso: "Effects of Allicin on Hypertension and Cardiac Function in Chronic Kidney Disease." in: Oxidative medicine and cellular longevity, Vol. 2016, pp. 3850402, (2017) (PubMed).

    Arellano-Buendía, Tostado-González, García-Arroyo, Cristóbal-García, Loredo-Mendoza, Tapia, Sánchez-Lozada, Osorio-Alonso: "Anti-Inflammatory Therapy Modulates Nrf2-Keap1 in Kidney from Rats with Diabetes." in: Oxidative medicine and cellular longevity, Vol. 2016, pp. 4693801, (2017) (PubMed).

  • Target
    NRF2 (NFE2L2) (Nuclear Factor (erythroid-Derived 2)-Like 2 (NFE2L2))
    Andere Bezeichnung
    NRF2 (NFE2L2 Produkte)
    Synonyme
    Nrf2 antikoerper, nfe2l2 antikoerper, wu:fc15g09 antikoerper, wu:fj67e03 antikoerper, NF-E2R2 antikoerper, NRF2 antikoerper, AI194320 antikoerper, nuclear factor, erythroid 2-like 2a antikoerper, nuclear factor, erythroid 2 like 2 S homeolog antikoerper, nuclear factor, erythroid 2 like 2 antikoerper, nuclear factor, erythroid derived 2, like 2 antikoerper, nuclear factor, erythroid 2-like 2 antikoerper, nfe2l2a antikoerper, nfe2l2.S antikoerper, NFE2L2 antikoerper, Nfe2l2 antikoerper
    Hintergrund
    NFE2 (MIM 601490), NFE2L1 (MIM 163260), and NFE2L2 comprise a family of human genes encoding basic leucine zipper (bZIP) transcription factors. They share highly conserved regions that are distinct from other bZIP families, such as JUN (MIM 165160) and FOS (MIM 164810), although remaining regions have diverged considerably from each other (Chan et al., 1995 [PubMed 7868116]).[supplied by OMIM]

    Cellular Localization: Cytoplasm , cytosol , Nucleus
    Molekulargewicht
    68 kDa110
    Gen-ID
    4780
    Pathways
    ER-Nucleus Signaling, Negative Regulation of intrinsic apoptotic Signaling
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