NRF2 Antikörper (pSer40)

Produktnummer ABIN676673

Es sind 19+ Publikationen für dieses Produkt verfügbar. Der Kaninchen Polyklonal anti-NRF2 Antikörper wird verwendet zum Nachweis von NRF2 in Proben von Human. Er wurde validiert für WB, FACS, IHC (p), IHC (fro), IF (cc) und IF (p).

Kurzübersicht für NRF2 Antikörper (pSer40) (ABIN676673)

Target: NRF2 (NFE2L2) (Nuclear Factor (erythroid-Derived 2)-Like 2 (NFE2L2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NRF2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Produktdetails anti-NRF2 Antikörper

Bindungsspezifität: pSer40

Verwendungszweck: phospho-Nrf2 (Ser40) Polyclonal Antibody

Kreuzreaktivität: Human, Maus

Homologie: Rat,Dog,Cow,Chicken

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic phosphopeptide derived from human Nrf2 around the phosphorylation site of Ser40 [DF(p-S)QR]

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB(1:300-5000),

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Referenzen für anti-NRF2 Antikörper (ABIN676673)

Ghosh, Abdo, Zhao, Wu, Shi, Lo, Chenier, Alquier, Filep, Ingelfinger, Zhang, Chan: "Insulin Inhibits Nrf2 Gene Expression via Heterogeneous Nuclear Ribonucleoprotein F/K in Diabetic Mice." in: Endocrinology, Vol. 158, Issue 4, pp. 903-919, (2017) (PubMed).

Allard, Perez, Fukui, Carpenter, Ingram, de Cabo: "Prolonged metformin treatment leads to reduced transcription of Nrf2 and neurotrophic factors without cognitive impairment in older C57BL/6J mice." in: Behavioural brain research, Vol. 301, pp. 1-9, (2016) (PubMed).

Yen, Chen, Jayakumar, Lu, Hsieh, Hsu, Yang, Chang, Lin, Lin, Sheu et al.: "Andrographolide stimulates p38 mitogen-activated protein kinase-nuclear factor erythroid-2-related factor 2-heme oxygenase 1 signaling in primary cerebral endothelial cells for definite protection ..." in: Translational research : the journal of laboratory and clinical medicine, Vol. 170, pp. 57-72, (2016) (PubMed).

Ko, Rho, Jeon, Kim, Woo, Kim, Kim: "Crude Preparations of Helicobacter pylori Outer Membrane Vesicles Induce Upregulation of Heme Oxygenase-1 via Activating Akt-Nrf2 and mTOR-IκB Kinase-NF-κB Pathways in Dendritic Cells." in: Infection and immunity, Vol. 84, Issue 8, pp. 2162-74, (2016) (PubMed).

Ko, Rho, Jeon, Kim, Woo, Lee, Kim: "Bacteroides fragilis Enterotoxin Upregulates Heme Oxygenase-1 in Intestinal Epithelial Cells via a Mitogen-Activated Protein Kinase- and NF-κB-Dependent Pathway, Leading to Modulation of Apoptosis." in: Infection and immunity, Vol. 84, Issue 9, pp. 2541-54, (2016) (PubMed).

Kim, Kim, Jung, Yang, Park, Jun: "EX4 stabilizes and activates Nrf2 via PKCδ, contributing to the prevention of oxidative stress-induced pancreatic beta cell damage." in: Toxicology and applied pharmacology, Vol. 315, pp. 60-69, (2016) (PubMed).

Cheng, Cheng, Lee, Chung, Chang: "Resveratrol protects against methylglyoxal-induced hyperglycemia and pancreatic damage in vivo." in: Nutrients, Vol. 7, Issue 4, pp. 2850-65, (2016) (PubMed).

Chang, Wu, Xu, Liao, Wu, Cheng: "Scopoletin Protects against Methylglyoxal-Induced Hyperglycemia and Insulin Resistance Mediated by Suppression of Advanced Glycation Endproducts (AGEs) Generation and Anti-Glycation." in: Molecules (Basel, Switzerland), Vol. 20, Issue 2, pp. 2786-801, (2015) (PubMed).

Kaneko, Takayanagi, Nagasaki, Kodani, Nakashima, Mori, Suzuki, Itoh, Kondo, Nagatsu, Ota, Ota: "Aripiprazole increases NAD(P)H-quinone oxidoreductase-1 and heme oxygenase-1 in PC12 cells." in: Journal of neural transmission (Vienna, Austria : 1996), Vol. 122, Issue 6, pp. 757-72, (2015) (PubMed).

Santofimia-Castaño, Clea Ruy, Garcia-Sanchez, Jimenez-Blasco, Fernandez-Bermejo, Bolaños, Salido, Gonzalez: "Melatonin induces the expression of Nrf2-regulated antioxidant enzymes via PKC and Ca(2+) influx activation in mouse pancreatic acinar cells." in: Free radical biology & medicine, (2015) (PubMed).

Mo, Wang, Zhang, Numazawa, Tang, Tang, Han, Li, Yang, Wang, Wei, Xiao: "The crosstalk between Nrf2 and AMPK signal pathways is important for the anti-inflammatory effect of berberine in LPS-stimulated macrophages and endotoxin-shocked mice." in: Antioxidants & redox signaling, Vol. 20, Issue 4, pp. 574-88, (2014) (PubMed).

Kakehashi, Kato, Ishii, Wei, Morimura, Fukushima, Wanibuchi: "Valerian inhibits rat hepatocarcinogenesis by activating GABA(A) receptor-mediated signaling." in: PLoS ONE, Vol. 9, Issue 11, pp. e113610, (2014) (PubMed).

Li, Guo, Xi, Yang, Zhou, Yin, Hai, Li, Qin: "Saponins from Aralia taibaiensis attenuate D-galactose-induced aging in rats by activating FOXO3a and Nrf2 pathways." in: Oxidative medicine and cellular longevity, Vol. 2014, pp. 320513, (2014) (PubMed).

Patwardhan, Sharma, Checker, Sandur: "Mitigation of radiation-induced hematopoietic injury via regulation of cellular MAPK/phosphatase levels and increasing hematopoietic stem cells." in: Free radical biology & medicine, Vol. 68, pp. 52-64, (2014) (PubMed).

Lee, Hsu, Hsu, Pan: "Dimerumic acid attenuates receptor for advanced glycation endproducts signal to inhibit inflammation and diabetes mediated by Nrf2 activation and promotes methylglyoxal metabolism into d-lactic acid." in: Free radical biology & medicine, Vol. 60, pp. 7-16, (2013) (PubMed).

Hsu, Lee, Li, Hsu, Pan: "Monascin and AITC attenuate methylglyoxal-induced PPAR? phosphorylation and degradation through inhibition of the oxidative stress/PKC pathway depending on Nrf2 activation." in: Journal of agricultural and food chemistry, Vol. 61, Issue 25, pp. 5996-6006, (2013) (PubMed).

Lee, Lee, Cheng, Chang, Hsu, Wu: "Graptopetalum paraguayense and resveratrol ameliorates carboxymethyllysine (CML)-induced pancreas dysfunction and hyperglycemia." in: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, Vol. 62, pp. 492-8, (2013) (PubMed).

Lee, Hsu, Chang, Kuo, Hsu, Pan: "Ankaflavin: a natural novel PPAR? agonist upregulates Nrf2 to attenuate methylglyoxal-induced diabetes in vivo." in: Free radical biology & medicine, Vol. 53, Issue 11, pp. 2008-16, (2012) (PubMed).

Details zu NRF2

Target: NRF2 (NFE2L2) (Nuclear Factor (erythroid-Derived 2)-Like 2 (NFE2L2))

Andere Bezeichnung: Nrf2

Hintergrund:

Synonyms: NRF2, Nuclear factor erythroid 2-related factor 2, NF-E2-related factor 2, NFE2-related factor 2, HEBP1, Nuclear factor, erythroid derived 2, like 2, NFE2L2

Background: Transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. Important for the coordinated up-regulation of genes in response to oxidative stress. May be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region.

Gen-ID: 4780

UniProt: Q16236

Pathways: ER-Nucleus Signaling, Negative Regulation of intrinsic apoptotic Signaling