NRF2 Antikörper (AA 430-480)

Produktnummer ABIN737271

Zitiert in 22+ Publikationen. Der Kaninchen Polyklonal anti-NRF2 Antikörper (ABIN737271) detektiert spezifisch NRF2 in WB, IF, ICC, FACS, IHC (p) und IHC (fro). Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für NRF2 Antikörper (AA 430-480) (ABIN737271)

Target: NRF2 (NFE2L2) (Nuclear Factor (erythroid-Derived 2)-Like 2 (NFE2L2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NRF2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Produktdetails anti-NRF2 Antikörper

Bindungsspezifität: AA 430-480

Verwendungszweck: Nrf2 Polyclonal Antibody

Kreuzreaktivität: Human, Maus, Ratte

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Nrf2

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB(1:1000-2000), IHC-P(1:100-500), IHC-F(1:100-500), IF(1:100-500), Flow-Cyt(1 μg/Test), ICC/IF(1:50-200)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: 0.01M TBS ( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Referenzen für anti-NRF2 Antikörper (ABIN737271)

Xu, Zheng, Liu, Li, Yang, Shang: "Glaucocalyxin B Alleviates Lipopolysaccharide-Induced Parkinson's Disease by Inhibiting TLR/NF-κB and Activating Nrf2/HO-1 Pathway." in: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, Vol. 44, Issue 6, pp. 2091-2104, (2018) (PubMed).

Zeng, Li, Zhang, Liu, Li, Xiong, He, Wang, Ye: "Tert-Butylhydroquinone Protects Liver Against Ischemia/Reperfusion Injury in Rats Through Nrf2-Activating Anti-Oxidative Activity." in: Transplantation proceedings, Vol. 49, Issue 2, pp. 366-372, (2017) (PubMed).

Zhang, Dong, Chen, Liu, Huang, Zhong, Cheng, Wang: "Nrf2 mediates the protective effects of homocysteine by increasing the levels of GSH content in HepG2 cells." in: Molecular medicine reports, Vol. 16, Issue 1, pp. 597-602, (2017) (PubMed).

Yu, Bei, Li, Han, Zhong, Liu, Zhao, Zhu, Zhao: "In vitro the differences of inflammatory and oxidative reactions due to sulfur mustard induced acute pulmonary injury underlying intraperitoneal injection and intratracheal instillation in rats." in: International immunopharmacology, Vol. 47, pp. 78-87, (2017) (PubMed).

Shen, Wu, Wang, Zhao, Zhang, Li, Zhao: "Chloroquine attenuates paraquat-induced lung injury in mice by altering inflammation, oxidative stress and fibrosis." in: International immunopharmacology, Vol. 46, pp. 16-22, (2017) (PubMed).

Zhang, Wang, Hao, Wang, Zhang, Muhammad, Qi, Li, Sun: "Nrf2 is crucial for the down-regulation of Cyp7a1 induced by arachidonic acid in Hepg2 cells." in: Environmental toxicology and pharmacology, Vol. 52, pp. 21-26, (2017) (PubMed).

Cao, Huang, Dou, Xiang, Dong: "Cyanidin suppresses autophagic activity regulating chondrocyte hypertrophic differentiation." in: Journal of cellular physiology, Vol. 233, Issue 3, pp. 2332-2342, (2017) (PubMed).

Kouam, Yuan, Njayou, He, Tsayem, Oladejo, Song, Moundipa, Gao: "Induction of Mkp-1 and Nuclear Translocation of Nrf2 by Limonoids from Khaya grandifoliola C.DC Protect L-02 Hepatocytes against Acetaminophen-Induced Hepatotoxicity." in: Frontiers in pharmacology, Vol. 8, pp. 653, (2017) (PubMed).

Jiang, Li, He, Yao, Bian, Wang, Zhu: "Protective Effects of Asiatic Acid Against Spinal Cord Injury-Induced Acute Lung Injury in Rats." in: Inflammation, Vol. 39, Issue 6, pp. 1853-1861, (2016) (PubMed).

Tang, Gao, Mao, He, Liu, Cai, Lin, Wu: "Salidroside protects against bleomycin-induced pulmonary fibrosis: activation of Nrf2-antioxidant signaling, and inhibition of NF-κB and TGF-β1/Smad-2/-3 pathways." in: Cell stress & chaperones, Vol. 21, Issue 2, pp. 239-49, (2016) (PubMed).

Wang, Peng, Wei, Wei, Wang, Ma, Yao, Fu, Zu: "Geraniin exerts cytoprotective effect against cellular oxidative stress by upregulation of Nrf2-mediated antioxidant enzyme expression via PI3K/AKT and ERK1/2 pathway." in: Biochimica et biophysica acta, Vol. 1850, Issue 9, pp. 1751-61, (2015) (PubMed).

Yu, Shi, Zhao, Sun, Gao, Sun, Qi: "Triptolide Attenuates Myocardial Ischemia/Reperfusion Injuries in Rats by Inducing the Activation of Nrf2/HO-1 Defense Pathway." in: Cardiovascular toxicology, (2015) (PubMed).

Lv, Mao, Wu, Lu, Ding, Gu, Wu, Shi: "Neuroprotective effect of allicin in a rat model of acute spinal cord injury." in: Life sciences, Vol. 143, pp. 114-23, (2015) (PubMed).

Lee, Lee, Wu: "Actinidia callosa peel (kiwi fruit) ethanol extracts protected neural cells apoptosis induced by methylglyoxal through Nrf2 activation." in: Pharmaceutical biology, Vol. 52, Issue 5, pp. 628-36, (2014) (PubMed).

Wang, Fang, Huang, Chen, Fan, Wang: "The chronic effects of low lead level on the expressions of Nrf2 and Mrp1 of the testes in the rats." in: Environmental toxicology and pharmacology, Vol. 35, Issue 1, pp. 109-16, (2013) (PubMed).

Lee, Hsu, Huang, Chang, Hsu, Pan: "Effects of monascin on anti-inflammation mediated by Nrf2 activation in advanced glycation end product-treated THP-1 monocytes and methylglyoxal-treated wistar rats." in: Journal of agricultural and food chemistry, Vol. 61, Issue 6, pp. 1288-98, (2013) (PubMed).

Hsu, Lee, Li, Hsu, Pan: "Monascin and AITC attenuate methylglyoxal-induced PPAR? phosphorylation and degradation through inhibition of the oxidative stress/PKC pathway depending on Nrf2 activation." in: Journal of agricultural and food chemistry, Vol. 61, Issue 25, pp. 5996-6006, (2013) (PubMed).

Lee, Hsu, Hsu, Pan: "Dimerumic acid attenuates receptor for advanced glycation endproducts signal to inhibit inflammation and diabetes mediated by Nrf2 activation and promotes methylglyoxal metabolism into d-lactic acid." in: Free radical biology & medicine, Vol. 60, pp. 7-16, (2013) (PubMed).

Lee, Lee, Cheng, Chang, Hsu, Wu: "Graptopetalum paraguayense and resveratrol ameliorates carboxymethyllysine (CML)-induced pancreas dysfunction and hyperglycemia." in: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, Vol. 62, pp. 492-8, (2013) (PubMed).

Details zu NRF2

Target: NRF2 (NFE2L2) (Nuclear Factor (erythroid-Derived 2)-Like 2 (NFE2L2))

Andere Bezeichnung: Nrf2

Hintergrund: Synonyms: NF2L2_HUMAN, Nuclear factor erythroid 2-related factor 2, NFE2L2, NF-E2-related factor 2, NFE2-related factor 2, Nrf-2, Nrf 2, Nuclear factor, erythroid derived 2, like 2, NFE2L2, NRF2, NFE2 like bZIP transcription factor 2, HEBP1, IMDDHH,

Gen-ID: 4780

UniProt: Q16236

Pathways: ER-Nucleus Signaling, Negative Regulation of intrinsic apoptotic Signaling