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Human Monoclonal NKX6-1 Primary Antibody für BI, IF - ABIN2689864
Donelan, Koya, Li, Yang: Distinct regulation of hepatic nuclear factor 1alpha by NKX6.1 in pancreatic beta cells. in The Journal of biological chemistry 2010
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Human Polyclonal NKX6-1 Primary Antibody für ICC, IF - ABIN4340070
Bader, Migliorini, Gegg, Moruzzi, Gerdes, Roscioni, Bakhti, Brandl, Irmler, Beckers, Aichler, Feuchtinger, Leitzinger, Zischka, Wang-Sattler, Jastroch, Tschöp, Machicao, Staiger, Häring, Chmelova et al.: Identification of proliferative and mature β-cells in the islets of Langerhans. ... in Nature 2016
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Human Polyclonal NKX6-1 Primary Antibody für ICC, IF - ABIN4340068
Theofilopoulos, Wang, Kitambi, Sacchetti, Sousa, Bodin, Kirk, Saltó, Gustafsson, Toledo, Karu, Gustafsson, Steffensen, Ernfors, Sjövall, Griffiths, Arenas: Brain endogenous liver X receptor ligands selectively promote midbrain neurogenesis. in Nature chemical biology 2013
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Data indicate the secretory granule membrane glycoprotein 2 as a marker for PDX1+/NKX6-1+ pancreatic progenitors (PPs).
Efficiency of differentiation of Induced pluripotent stem cells to insulin (zeige INS Antikörper) producing cells can be increased by concurrent expression of PDX1 (zeige PDX1 Antikörper) and NKX6.1 during progenitor cells maturation.
NKX6.1 directly enhances the mRNA level of E-cadherin (zeige CDH1 Antikörper) by recruiting BAF155 (zeige SMARCC1 Antikörper) coactivator and represses that of vimentin (zeige VIM Antikörper) and N-cadherin (zeige CDH2 Antikörper) by recruiting RBBP7 (retinoblastoma binding protein 7 (zeige RBBP7 Antikörper)) corepressor.
NKX6.1 is a factor for IL-6 (zeige IL6 Antikörper)-regulated growth and tumor formation in basal-like breast cancer.
a significant relationship was observed between NKX6.1 and EMT (zeige ITK Antikörper) marker expression levels, and NKX6.1 knockdown inhibited cell invasion, and overexpression of NKX6.1 promotes cell proliferation in vitro.
study evaluated the potential use of NKX6-1 as a diagnostic marker for well-differentiated neuroendocrine tumors
NKX6-1 reveals wide variations in methylation levels in normal control samples of cervical adenocarcinomas.
Mice transplanted with NKX6.1-low cells remained hyperglycemic throughout the 5-month post-transplant period whereas diabetes was reversed in NKX6.1-high recipients within 3 months.
MAFA (zeige KLRG1 Antikörper), MAFB (zeige MAFB Antikörper), NKX6.1, and PDX1 (zeige PDX1 Antikörper) activity provides a gauge of islet beta cell function, with loss of MAFA (zeige KLRG1 Antikörper) (and/or MAFB (zeige MAFB Antikörper)) representing an early indicator of beta cell inactivity
Smooth muscle cells expressing nestin (zeige NES Antikörper) and Nkx6.1 are the main cell population derived from culturing human spinal cord cells in adherent conditions with serum.
nkx6.1 regulates the alpha- and beta-cell formation in zebrafish by acting on the stem cells in the Islets of Langerhans.
In zebrafish, Nkx6.1 is expressed in early-born primary and later-born secondary motoneurons
Study shows that zebrafish primary motoneurons express two related transcription factors Nkx6.1 and Nkx6.2; in their absence, the CaP motoneuron subtype develops normally, whereas the MiP (zeige MIP Antikörper) motoneuron subtype develops a interneuron-like morphology.
The results suggest that Nkx6.1 is involved in mid-hindbrain formation in Xenopus embryos, likely by modulating wnt1 (zeige WNT1 Antikörper) expression.
Nkx6.1 and Nkx6.2 share overlapping expression domains in the ventral neural tube at neurula stages and later in the ventral part of developing hindbrain and spinal cord. Nkx6.3 (zeige NKX6-3 Antikörper) is detected in the non-neural ectoderm.
Nkx6.1 plays a vital role in astrocyte specification and differentiation in the ventral spinal cord.
MAFA (zeige MAFA Antikörper), MAFB (zeige MAFB Antikörper), NKX6.1, and PDX1 (zeige PDX1 Antikörper) activity provides a gauge of islet beta cell function, with loss of MAFA (zeige MAFA Antikörper) (and/or MAFB (zeige MAFB Antikörper)) representing an early indicator of beta cell inactivity
Over time, Nkx6.1-deficient beta cells acquired molecular characteristics of delta cells, revealing a molecular link between impaired beta cell functional properties and loss of cell identity.
Our findings establish Nkx6.1 as a beta (zeige SUCLA2 Antikörper) cell programming factor and demonstrate that repression of alternative lineage programs is a fundamental principle by which beta cells are specified and maintained.
Data found direct binding of RBP (zeige RBP4 Antikörper)-jkappa to the Nkx6.1 proximal promoter.
Results demonstrate that sustained Nkx6.1 overexpression in vivo does not stimulate beta-cell proliferation, expand beta-cell mass, or improve glucose metabolism in either normal or beta-cell-depleted pancreata.
Nkx6 genes pattern the frog neural plate and Nkx6.1 is necessary for motoneuron axon projection.
Data show a longitudinal domain positive for both Nkx6.1 and Nkx6.2 that is medial to the Pou4f1 (zeige POU4F1 Antikörper)-positive red nucleus. This domain could correspond to part of the reticular formation, which extends from the diencephalon and the mesencephalon.
Ependymal cells in adult spinal cord are derived from Nkx6.1+ ventral neural progenitor cells. Nkx6.1+ ependymal cells in adult mouse spinal cords may retain the proliferative property of neural stem cells.
Results demonstrate a requirement for Nkx6.1 in the development of postmitotic motoneurons, and suggest a cell-autonomous function in the control of branchio-motoneuron migration.
In the pancreas, NKX6.1 is required for the development of beta cells and is a potent bifunctional transcription regulator that binds to AT-rich sequences within the promoter region of target genes Iype et al. (2004)
NK6 transcription factor related, locus 1
, NK6 homeobox 1
, NK homeo box, family 6, member A
, NK homeobox, family 6, A
, NK6 transcription factor homolog A
, homeobox protein NK-6 homolog A
, homeobox protein Nkx-6.1
, NK6 transcription factor related locus 1
, Drosophila NK transcription factor related, gene family 6, locus 1
, homeodomain transcription factor Nkx6.1