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NKX6-1 Antikörper

NKX6-1 Reaktivität: Human IHC (f) Wirt: Maus Monoclonal NKX61-2561 unconjugated
Produktnummer ABIN6938077
  • Target Alle NKX6-1 Antikörper anzeigen
    NKX6-1 (NK6 Homeobox 1 (NKX6-1))
    Reaktivität
    • 44
    • 24
    • 12
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Human
    Wirt
    • 37
    • 6
    • 1
    • 1
    Maus
    Klonalität
    • 39
    • 6
    Monoklonal
    Konjugat
    • 26
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser NKX6-1 Antikörper ist unkonjugiert
    Applikation
    • 35
    • 24
    • 7
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Immunohistochemistry (Formalin-fixed Sections) (IHC (f))
    Spezifität
    Members of the Nkx family of homeodomain proteins are key regulators of growth and development in several tissues, including brain, heart and pancreas. During neural development, sonic hedgehog (Shh) is known to control cell fate and mitogenesis, which is correlated with Shh dose-dependent expression of several genes, including Nkx-6.1. Specifically, Nkx-6.1 is responsible for cellular differentiation in the ventral neural tube and spinal meninges in response to Shh. In the pancreas, Nkx-6.1 is exclusively expressed in the islets of Langerhans in differentiating and mature B cells, which produce Insulin. The presence of Pdx-1 is required for the expression of Nkx-6.1 as well as other pancreatic B cell specific genes, including Insulin, Glut2 and IAPP. Subsequently, Nkx-6.1 binds to the DNA consensus sequence, TTAATTAC, to direct the repression of specific genes in B cells. Nkx6.1 is highly expressed in pancreatic and duodenal well-differentiated neuroendocrine tumors (WDNETS) and in metastatic WDNETS, is a highly specific marker of tumors of pancreatic origin. It has thus been suggested that Nkx6.1 is a useful inclusion into IHC panels for identifying primary sites of WDNETS.
    Kreuzreaktivität (Details)
    Human.
    Aufreinigung
    1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
    Immunogen
    Recombinant full-length human NKX6.1 protein
    Klon
    NKX61-2561
    Isotyp
    IgG2c kappa
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    Discover our top product NKX6-1 Primärantikörper
  • Applikationshinweise

    Known_Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes), Optimal dilution for a specific application should be determined.

    Positive_Control: Human fetal small intestine lysate or pancreas tissue.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    1.0 mg/mL
    Buffer
    Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
    Konservierungsmittel
    Azide free
    Lagerung
    -20 °C,-80 °C
    Informationen zur Lagerung
    Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
    Haltbarkeit
    24 months
  • Target
    NKX6-1 (NK6 Homeobox 1 (NKX6-1))
    Andere Bezeichnung
    NKX6-1 (NKX6-1 Produkte)
    Synonyme
    nkx6a antikoerper, nkx6.1 antikoerper, NKX6.1 antikoerper, NKX6A antikoerper, zgc:92879 antikoerper, Nkx6.1 antikoerper, Nkx61 antikoerper, Nkx6a antikoerper, NK6 homeobox 1 antikoerper, NK6 homeobox 1 L homeolog antikoerper, nkx6-1 antikoerper, NKX6-1 antikoerper, nkx6.1 antikoerper, nkx6-1.L antikoerper, Nkx6-1 antikoerper
    Hintergrund
    Homeobox protein NK-6 homolog A, NK homeobox, family 6, A, NK6 homeobox 1, NK6 transcription factor homolog A, NK6 transcription factor related, locus 1 (Drosophila), NKX6-1, NKX6A,NKX6.1 (Marker for Pancreatic and Duodenal Neuroendocrine Tumors)
    Cellular localisation: Nuclear
    Molekulargewicht
    40-50kDa
    Gen-ID
    4825, 546270
    UniProt
    P78426
    Pathways
    Dopaminergic Neurogenesis, Positive Regulation of Peptide Hormone Secretion
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