The protein encoded by this gene is a noncollagenous extracellular matrix (ECM) protein. It consists of five identical glycoprotein subunits, each with EGF-like and calcium-binding (thrombospondin-like) domains. Oligomerization results from formation of a five-stranded coiled coil and disulfides. Binding to other ECM proteins such as collagen appears to depend on divalent cations. Mutations can cause the osteochondrodysplasias pseudochondroplasia (PSACH) and multiple epiphyseal dysplasia (MED). [provided by RefSeq, Jul 2008].
Wang, Chen, Xiang, Wu, Tang, Ma, Zhang: "ADAMTS7 degrades Comp to fuel BMP2-dependent osteogenic differentiation and ameliorate oncogenic potential in osteosarcomas." in: FEBS open bio, Vol. 10, Issue 9, pp. 1856-1867, (2020) (PubMed).
Spitznagel, Nitsche, Paulsson, Maurer, Zaucke: "Characterization of a pseudoachondroplasia-associated mutation (His587-->Arg) in the C-terminal, collagen-binding domain of cartilage oligomeric matrix protein (COMP)." in: The Biochemical journal, Vol. 377, Issue Pt 2, pp. 479-87, (2004) (PubMed).
Aliase für COMP Proteine
cartilage oligomeric matrix protein (COMP) Proteine cartilage oligomeric matrix protein (sce3551) Proteine cartilage oligomeric matrix protein (CJA_1292) Proteine cartilage oligomeric matrix protein (Comp) Proteine COMP Proteine EDM1 Proteine EPD1 Proteine MED Proteine PSACH Proteine THBS5 Proteine TSP5 Proteine