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Human Monoclonal LOXL2 Primary Antibody für ELISA, WB - ABIN561690
Fujimoto, Tajima: Reciprocal regulation of LOX and LOXL2 expression during cell adhesion and terminal differentiation in epidermal keratinocytes. in Journal of dermatological science 2009
Show all 3 Pubmed References
Human Polyclonal LOXL2 Primary Antibody für ELISA, WB - ABIN561689
Ghiggeri, Gigante, Di Donato et al.: Constitutional Nephrin Deficiency in Conditionally Immortalized Human Podocytes Induced Epithelial-Mesenchymal Transition, Supported by β-Catenin/NF-kappa B Activation: A Consequence of Cell Junction ... in International journal of nephrology 2014
Human Polyclonal LOXL2 Primary Antibody für ICC, IF - ABIN442901
Wong, Zhang, Gilkes, Chen, Wei, Chaturvedi, Hubbi, Semenza: Inhibitors of hypoxia-inducible factor 1 block breast cancer metastatic niche formation and lung metastasis. in Journal of molecular medicine (Berlin, Germany) 2012
Dmloxl-1 and Dmloxl-2 are differentially expressed; active DmLOXL-1 influences gene expression and development
higher LOXL2 expression is associated with the invasiveness of pancreatic cancer cells and the low survival rate of pancreatic cancer patients
LOXL2 c.C133T is a pathogenic mutation that is responsible for a fraction of familial intracranial aneurysms.
data demonstrate that proteolytic processing is an important event that allows LOXL2-mediated crosslinking of basement membrane collagen IV (zeige COL4 Antikörper).
new LOXL2 splice variant contributes to tumor progression by novel molecular mechanisms different from LOXL2WT
LOXL2 is a potential therapeutic target against tumor progression.
Insulin (zeige INS Antikörper) resistance promotes lysyl oxidase like 2 induction and fibrosis accumulation in non-alcoholic fatty liver disease.
SMYD3 (zeige SMYD3 Antikörper) enhances tumorigenicity in esophageal squamous cell carcinoma by enhancing transcription of ezrin (zeige EZR Antikörper) and LOXL2, which are involved in proliferation, migration, and invasion.
Data show that lysyl oxidase-like 2 (LOXL2) is a histone modifier enzyme that removes trimethylated lysine 4 (K4) in histone H3 (zeige HIST3H3 Antikörper) (H3K4me3) through an amino-oxidase reaction.
LOXL2 was determined to promote proliferation of hepatocellular carcinoma (HCC (zeige FAM126A Antikörper)) and demonstrated to be highly expressed in HCC (zeige FAM126A Antikörper) adjacent non-tumor tissue samples compared with tumor tissue samples.
LOXL2 messenger RNA levels were increased in intrahepatic cholangiocarcinoma. These results were confirmed at a protein level, with a significantly higher LOXL2 immunostaining tumoral stroma. Univariate analysis revealed that LOXL2 expression was correlated with a poor overall survival and disease-free survival.
Findings indicate a pathophysiologic role and function for lysyl oxidase (zeige LOX Antikörper)-like protein LOXL2 (zeige LOXL3 Antikörper) in breast cancer metastasis.
Insulin (zeige INS Antikörper) resistance promotes lysyl oxidase like 2 (zeige LOXL3 Antikörper) induction and fibrosis accumulation in non-alcoholic fatty liver disease.
glomerular extracellular matrix. Altogether, we demonstrate that LOXL2 (zeige LOXL3 Antikörper) is a novel component of the molecular machinery that forms cross-linked collagen IV (zeige COL4 Antikörper) networks, which are essential for glomerular basement membrane stability and molecular ultrafiltration function.
LOX (zeige LOX Antikörper) and LOXL2 (zeige LOXL3 Antikörper) may play an important role in the pathogenesis of AMD (zeige AMD1 Antikörper). Targeting LOXL2 (zeige LOXL3 Antikörper) could have a broader efficacy than targeting LOX (zeige LOX Antikörper), by reducing angiogenesis and inflammation, as well as fibrosis.
Loss and gain of function analyses combined with in vivo studies in syngeneic breast cancer models demonstrate the participation of LOXL2 (zeige LOXL3 Antikörper) and E47 (zeige TCF3 Antikörper) in tumor growth and their requirement for lung metastasis.
Findings reveal new insight into the mechanisms of fibroblast activation, a novel function of LOXL2 (zeige LOXL3 Antikörper), and further highlight the importance of generating LOXL2 (zeige LOXL3 Antikörper)-targeted therapies for the prevention of tumor progression and metastasis.
The Snail1 (zeige SNAI1 Antikörper) transcription factor represses mouse pericentromeric transcription, acting through the H3K4 deaminase LOXL2 (zeige LOXL3 Antikörper).
The enzymatic activity of lysyl oxidas-like-2 (LOXL2 (zeige LOXL3 Antikörper)) is not required for LOXL2 (zeige LOXL3 Antikörper)-induced inhibition of keratinocyte differentiation.
This study provides the first evidence for the role of LOXL2 (zeige LOXL3 Antikörper) in regulating angiogenesis through collagen IV (zeige COL4 Antikörper) scaffolding.
LOXL2 (zeige LOXL3 Antikörper) promotes chondrocyte differentiation by mechanisms that are likely to include roles as both a regulator and an effector of chondrocyte differentiation
This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family.
, lysyl oxidase-like 2
, Lysyl oxidase-like protein 2
, lysyl oxidase homolog 2
, lysyl oxidase homolog 2-like
, lysyl oxidase related 2
, lysyl oxidase-like protein 2
, lysyl oxidase-related protein 2
, lysyl oxidase-related protein WS9-14
, Lysyl oxidase homolog 2