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Our present data suggest that decreased elastin renewal due to LOXL2 mutations and consecutive reduced LOXL2 expression contribute to the pathogenesis of MDE.
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although Loxl2 is expressed in both dermis and epidermis, its function appears largely confined to the epidermis.
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we report that overexpression of LOXL2 promotes its accumulation in the Endoplasmic Reticulum where it interacts with HSPA5 leading to activation of the IRE1-XBP1 signalling pathway of the ER-stress response.
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Copper loading robustly activates hLOXL2 and supports lysyl tyrosylquinone formation.
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LOXL2 might have an important role in CRC.
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Results revealed that LOXL2 expression was higher in hepatocellular carcinoma (HCC) cell lines and tissues. There was a significant correlation between EMT status and LOXL2 levels indicated that a higher level of LOXL2 may contribute to tumor progression.
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Plasma LOXL2 was significantly elevated and also strongly correlated with the degree of left atrial fibrosis in Atrial fibrillation patients with normal left ventricular function.
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LOXL2 may be involved in the pathogenesis of rheumatoid arthritis-associated interstitial lung disease and might be helpful in early diagnosis of RA-ILD.
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LOXL1/LOXL2 gene expression and protein levels were increased in Idiopathic pulmonary fibrosis (IPF) versus non-IPF.
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This study focused on the relationship between lysyl oxidase (LOX), LOX-like protein 1 (LOXL1), and LOXL2 and pulmonary emphysema pathogenesis.
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Glomerular LOXL2 was localized to the cytoplasm of podocytes, as determined by double immunofluorescence microscopy using a podocyte marker (synaptopodin). This result was supported by western blot analysis, which demonstrated that LOXL2 protein expression is present in cultured human podocytes and HK2 human proximal tubular cells.
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Lysyl oxidase like-2 (LOXL2) overexpression differentially regulates signaling pathways in osteoarthritis chondrocytes.
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our data reveal that the tumor-promoting role of LOXL2 in ESCC is mediated by perturbing the architecture of actin cytoskeleton through its PPIs.
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HIF-1alpha plays an important role in the development of HCC by promoting HCC metastasis, EMT and VM through up-regulating LOXL2.
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Participants were evaluated as part of a clinical trial evaluating the safety and efficacy of simtuzumab a humanized monoclonal antibody that inhibits lysyl oxidase-like 2 (LOXL2), an enzyme that contributes to liver fibrosis by catalyzing collagen cross-linkage
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expression of LOXL2 endowed dormant tumor cells with cancer stem cell-like phenotype driving their transition to metastatic outgrowth and this stem-like phenotype is dependent on epithelial to mesenchymal transition (EMT) that can be driven by the tumor microenvironment.
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Simtuzumab is a humanized IgG4 monoclonal antibody that inhibits enzymatic activity of LOXL2... inhibition of LOXL2 expression reduced numbers of activated fibroblasts, decreased ECM deposition, inhibited angiogenesis, and prevented tumor cell invasion and metastases
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higher LOXL2 expression is associated with the invasiveness of pancreatic cancer cells and the low survival rate of pancreatic cancer patients
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LOXL2 c.C133T is a pathogenic mutation that is responsible for a fraction of familial intracranial aneurysms.
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data demonstrate that proteolytic processing is an important event that allows LOXL2-mediated crosslinking of basement membrane collagen IV.
