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Human Monoclonal LOXL2 Primary Antibody für ELISA, WB - ABIN561690
Fujimoto, Tajima: Reciprocal regulation of LOX and LOXL2 expression during cell adhesion and terminal differentiation in epidermal keratinocytes. in Journal of dermatological science 2009
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Human Polyclonal LOXL2 Primary Antibody für ICC, IF - ABIN442901
Wong, Zhang, Gilkes, Chen, Wei, Chaturvedi, Hubbi, Semenza: Inhibitors of hypoxia-inducible factor 1 block breast cancer metastatic niche formation and lung metastasis. in Journal of molecular medicine (Berlin, Germany) 2012
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Human Polyclonal LOXL2 Primary Antibody für ELISA, WB - ABIN561689
Ghiggeri, Gigante, Di Donato et al.: Constitutional Nephrin Deficiency in Conditionally Immortalized Human Podocytes Induced Epithelial-Mesenchymal Transition, Supported by β-Catenin/NF-kappa B Activation: A Consequence of Cell Junction ... in International journal of nephrology 2014
LOXL2 might have an important role in CRC (zeige CALR Antikörper).
Results revealed that LOXL2 expression was higher in hepatocellular carcinoma (HCC (zeige FAM126A Antikörper)) cell lines and tissues. There was a significant correlation between EMT (zeige ITK Antikörper) status and LOXL2 levels indicated that a higher level of LOXL2 may contribute to tumor progression.
Plasma LOXL2 was significantly elevated and also strongly correlated with the degree of left atrial fibrosis in Atrial fibrillation patients with normal left ventricular function.
LOXL2 may be involved in the pathogenesis of rheumatoid arthritis-associated interstitial lung disease and might be helpful in early diagnosis of RA-ILD.
LOXL1 (zeige LOXL1 Antikörper)/LOXL2 gene expression and protein levels were increased in Idiopathic pulmonary fibrosis (IPF) versus non-IPF.
This study focused on the relationship between lysyl oxidase (LOX (zeige LOX Antikörper)), LOX (zeige LOX Antikörper)-like protein 1 (LOXL1 (zeige LOXL1 Antikörper)), and LOXL2 and pulmonary emphysema pathogenesis.
Glomerular LOXL2 was localized to the cytoplasm of podocytes, as determined by double immunofluorescence microscopy using a podocyte marker (synaptopodin). This result was supported by western blot analysis, which demonstrated that LOXL2 protein expression is present in cultured human podocytes and HK2 human proximal tubular cells.
Lysyl oxidase like-2 (LOXL2) overexpression differentially regulates signaling pathways in osteoarthritis chondrocytes.
our data reveal that the tumor-promoting role of LOXL2 in ESCC is mediated by perturbing the architecture of actin cytoskeleton through its PPIs.
HIF-1alpha (zeige HIF1A Antikörper) plays an important role in the development of HCC (zeige FAM126A Antikörper) by promoting HCC (zeige FAM126A Antikörper) metastasis, EMT (zeige ITK Antikörper) and VM through up-regulating LOXL2.
Dmloxl-1 and Dmloxl-2 are differentially expressed; active DmLOXL-1 influences gene expression and development
LOXL2 (zeige LOXL3 Antikörper) controls myofibroblast transformation and migration.
The mRNA and protein expression levels of LOXL2 (zeige LOXL3 Antikörper) were higher in a mouse model of tubulointerstitial fibrosis compared with in control mice.
Findings indicate a pathophysiologic role and function for lysyl oxidase (zeige LOX Antikörper)-like protein LOXL2 (zeige LOXL3 Antikörper) in breast cancer metastasis.
Insulin (zeige INS Antikörper) resistance promotes lysyl oxidase like 2 (zeige LOXL3 Antikörper) induction and fibrosis accumulation in non-alcoholic fatty liver disease.
glomerular extracellular matrix. Altogether, we demonstrate that LOXL2 (zeige LOXL3 Antikörper) is a novel component of the molecular machinery that forms cross-linked collagen IV (zeige COL4 Antikörper) networks, which are essential for glomerular basement membrane stability and molecular ultrafiltration function.
LOX (zeige LOX Antikörper) and LOXL2 (zeige LOXL3 Antikörper) may play an important role in the pathogenesis of AMD (zeige AMD1 Antikörper). Targeting LOXL2 (zeige LOXL3 Antikörper) could have a broader efficacy than targeting LOX (zeige LOX Antikörper), by reducing angiogenesis and inflammation, as well as fibrosis.
Loss and gain of function analyses combined with in vivo studies in syngeneic breast cancer models demonstrate the participation of LOXL2 (zeige LOXL3 Antikörper) and E47 (zeige TCF3 Antikörper) in tumor growth and their requirement for lung metastasis.
Findings reveal new insight into the mechanisms of fibroblast activation, a novel function of LOXL2 (zeige LOXL3 Antikörper), and further highlight the importance of generating LOXL2 (zeige LOXL3 Antikörper)-targeted therapies for the prevention of tumor progression and metastasis.
The Snail1 (zeige SNAI1 Antikörper) transcription factor represses mouse pericentromeric transcription, acting through the H3K4 deaminase LOXL2 (zeige LOXL3 Antikörper).
The enzymatic activity of lysyl oxidas-like-2 (LOXL2 (zeige LOXL3 Antikörper)) is not required for LOXL2 (zeige LOXL3 Antikörper)-induced inhibition of keratinocyte differentiation.
results suggest that LOXL2 could be an appealing target for treatment of scar formation after glaucoma surgery, and point to the potential therapeutic benefits of simtuzumab, a humanized monoclonal antibody derived from GS-607601.
This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family.
lysyl oxidase homolog 2
, lysyl oxidase related 2
, lysyl oxidase-like protein 2
, lysyl oxidase-related protein 2
, lysyl oxidase-related protein WS9-14
, lysyl oxidase-like 2
, Lysyl oxidase-like protein 2
, lysyl oxidase homolog 2-like
, Lysyl oxidase homolog 2
, Lysyl oxidase-like protein 2B