Rekombinanter LOXL2 Antikörper

Produktnummer ABIN7127602

Produktdetails anti-LOXL2 Antikörper

Target: LOXL2 (Lysyl Oxidase-Like 2 (LOXL2))

Antikörpertyp: Recombinant Antibody

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser LOXL2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FACS)

Kreuzreaktivität: Human, Maus, Ratte

Aufreinigung: Affinity-chromatography

Immunogen: A synthesized peptide derived from human LOXL2

Klon: 2E5

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: WB:1:500-1:5000, IHC:1:50-1:200, IF:1:20-1:200, FC:1:20-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu LOXL2

Target: LOXL2 (Lysyl Oxidase-Like 2 (LOXL2))

Andere Bezeichnung: LOXL2 (LOXL2 Produkte)

Synonyme: LOR2 antikoerper, WS9-14 antikoerper, CG4402 antikoerper, Dmel\\CG4402 antikoerper, Dmloxl-2 antikoerper, dmlox-2 antikoerper, 1110004B06Rik antikoerper, 4930526G11Rik antikoerper, 9430067E15Rik antikoerper, GB13360 antikoerper, lox2-like antikoerper, LOXL2 antikoerper, lor2 antikoerper, loxl-2 antikoerper, ws9-14 antikoerper, im:7136137 antikoerper, si:dkeyp-32b1.1 antikoerper, wu:fk12g04 antikoerper, zgc:158414 antikoerper, lysyl oxidase like 2 antikoerper, lysyl oxidase-like 2 antikoerper, lysyl oxidase homolog 4 antikoerper, lysyl oxidase like 2 L homeolog antikoerper, lysyl oxidase-like 2b antikoerper, LOXL2 antikoerper, lox2 antikoerper, Loxl2 antikoerper, LOC408544 antikoerper, loxl2.L antikoerper, loxl2 antikoerper, loxl2b antikoerper

Hintergrund:

Background: Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine). When secreted in extracellular matrix, promotes cross-linking of extracellular matrix proteins by mediating oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. Acts as a regulator of sprouting angiogenesis, probably via collagen IV scaffolding. When nuclear, acts as a transcription corepressor and specifically mediates deamination of trimethylated 'Lys-4' of histone H3 (H3K4me3), a specific tag for epigenetic transcriptional activation. Involved in epithelial to mesenchymal transition (EMT) via interaction with SNAI1 and participates in repression of E-cadherin, probably by mediating deamination of histone H3. Also involved in E-cadherin repression following hypoxia, a hallmark of epithelial to mesenchymal transition believed to amplify tumor aggressiveness, suggesting that it may play a role in tumor progression. Acts as a regulator of chondrocyte differentiation, probably by regulating expression of factors that control chondrocyte differentiation.

Aliases: Lysyl oxidase homolog 2 (EC 1.4.3.13) (Lysyl oxidase-like protein 2) (Lysyl oxidase-related protein 2) (Lysyl oxidase-related protein WS9-14), LOXL2

UniProt: Q9Y4K0

Pathways: Chromatin Binding