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anti-Mouse (Murine) LMO2 Antikörper:
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Human Monoclonal LMO2 Primary Antibody für FACS, ELISA - ABIN1098128
Cubedo, Maurin, Jiang, Lossos, Wright: PRDM1/Blimp1 downregulates expression of germinal center genes LMO2 and HGAL. in The FEBS journal 2011
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Human Monoclonal LMO2 Primary Antibody für IF, IHC (p) - ABIN2475347
Bazan, Scott: Dietary omega-3 fatty acids and accumulation of docosahexaenoic acid in rod photoreceptor cells of the retina and at synapses. in Upsala journal of medical sciences. Supplement 1991
Show all 3 Pubmed References
Human Monoclonal LMO2 Primary Antibody für ChIP, ICC - ABIN259552
Natkunam, Zhao, Mason, Chen, Taidi, Jones, Hammer, Hamilton Dutoit, Lossos, Levy: The oncoprotein LMO2 is expressed in normal germinal-center B cells and in human B-cell lymphomas. in Blood 2007
Genome-wide analysis indicated that LMO2 is required at the hemangioblast stage to position the TAL1 (zeige TAL1 Antikörper)/LMO2/LDB1 (zeige LDB1 Antikörper) complex to regulatory elements that are important for the establishment of the hematopoietic developmental program.
DNM2 (zeige DNM2 Antikörper) mutations cooperate with Lmo2 T-cell oncogenes by enhancing IL-7 (zeige IL7 Antikörper) signalling.
Hhex (zeige HHEX Antikörper) regulates Kit to promote radioresistance of self-renewing thymocytes in Lmo2-transgenic mice.
HHEX (zeige HHEX Antikörper) is a direct transcriptional target of LMO2 consistent with its concordant gene expression.
GATA2 (zeige GATA2 Antikörper) and Lmo2 cooperatively regulate VEGF (zeige VEGFA Antikörper)-induced angiogenesis and lymphangiogenesis via NRP2 (zeige NRP2 Antikörper).
a regulatory hierarchy of HOX (zeige MSH2 Antikörper) control of LMO2 in normal development
Lyl1 is critical for all oncogenic functions of Lmo2, including upregulation of a stem cell-like gene signature, aberrant self-renewal of thymocytes, and subsequent generation of T-cell leukemia.
A model in which the distal control region functions through a chromatin looping mechanism to contact and enhance Lmo2 transcription specifically in erythroid cells.
Studied the solution structure of Lmo2(LIM2 (zeige LHX2 Antikörper)) /Ldb1 (zeige LDB1 Antikörper)(LID) complex. Results show modular binding of tandem LIM (zeige PDLIM5 Antikörper) domains in Lmo2 to tandem linear motifs in Ldb1 (zeige LDB1 Antikörper) is accompanied by several disorder-to-order transitions/ conformational changes in both proteins.
Studies demonstrate that Etv2 (zeige ETV2 Antikörper) is expressed during and required for yolk sac (zeige ADCY10 Antikörper) hematoendothelial development, and that Lmo2 is one of the downstream targets of Etv2 (zeige ETV2 Antikörper).
LMO2 has a predominantly cytoplasmic location in breast cancer cells. LMO2 interaction with cofilin1 regulates actin cytoskeleton dynamics, promoting tumor cell invasion and metastasis.
These data indicate that Lhx2 (zeige LHX2 Antikörper) is capable of blocking proliferation of T-ALL-derived cells by both LMO2-dependent and -independent means. We propose Lhx2 (zeige LHX2 Antikörper) as a new molecular tool for anti-T-ALL drug development.
stromal LMO2 may be responsible for zonal characteristic of Prostate cancer
The transcriptional factor LMO2 regulates endothelial proliferation and angiogenesis in vitro.
This article demonstrates a novel and unexpected function of the LMO2 oncogenic transcription factor in controlling DNA replication that we unravelled via an unbiased proteome-wide screen for LMO2-interacting partners.
Findings suggest that LMO2 loss may be a good predictor for the presence of MYC (zeige MYC Antikörper) translocation in large B-cell lymphoma.
FOXP3 (zeige FOXP3 Antikörper) binds LMO2 in vitro, resulting in decreased interaction between LMO2 and TAL1 (zeige TAL1 Antikörper), providing a molecular mechanism for FOXP3 (zeige FOXP3 Antikörper)-mediated transcriptional modulation in T-ALL.
recurrent activating intronic mutations of LMO2, a prominent oncogene (zeige RAB1A Antikörper) in T-cell acute lymphoblastic leukemia (T-ALL). Heterozygous mutations were identified in PF-382 and DU.528 T-ALL cell lines in addition to 3.7% of pediatric (6 of 160) and 5.5% of adult (9 of 163) T-ALL patient samples.
Data indicate a novel functional mechanism of LMO2 in facilitating the delivery of actin monomers to the branched microfilament and increasing lamellipodia/filopodia formation in basal-type breast cancer cells.
we demonstrate previously unrecognized mechanisms by which LMO2 alters human T-cell development in vivo; these mechanisms correlate with human T-ALL leukemogenesis.
The transcriptional factor LMO2 regulates endothelial proliferation and angiogenesis in vitro. Furthermore, LMO2 is required for angiogenesis and tissue healing in vivo. Thus, LMO2 is a critical determinant of vascular and tissue regeneration.
a loss-of-function mutation in lmo2, a gene specifically required for hematopoiesis and vascular development, results in failure of optic fissure closure
in the absence of inducers of erythroid or myeloid haematopoiesis, Scl/Tal1 (zeige TAL1 Antikörper)-Lmo2-induced haemangioblasts differentiate into endothelial cells
Transcriptional regulation of lmo2 promoter during hematopoietic and vascular development in zebrafish is elucidated.
Scl (zeige TAL1 Antikörper)/Lmo2 complex does not appear to autoregulate, as neither gene's expression is affected by depletion of the other
LMO2 encodes a cysteine-rich, two LIM-domain protein that is required for yolk sac erythropoiesis. The LMO2 protein has a central and crucial role in hematopoietic development and is highly conserved. The LMO2 transcription start site is located approximately 25 kb downstream from the 11p13 T-cell translocation cluster (11p13 ttc), where a number T-cell acute lymphoblastic leukemia-specific translocations occur. Alternative splicing results in multiple transcript variants encoding different isoforms.
, LIM domain only 2 (rhombotin-like 1)
, LIM domain only protein 2
, LIM only 2
, T-cell translocation protein 2
, cysteine-rich protein TTG-2
, T-cell translocation gene 2
, rhombotin 2
, rhombotin-like 1
, LIM domain only-2