IL-10 Proteine (IL10)

Human Interleukin 10 (IL10) Interaktionspartner

1. IL-10/JAK1 signaling might be a potential therapeutic target for NSCLC treatment.

2. Significantly higher levels of cecal and colonic iNos expression and gammaH2AX-positive epithelial cells (a biomarker for double-strand DNA breaks [DSB]) in Hh-infected Rag2Il10gpt males vs. Hh-infected females were noted.

3. IL10 expression was down-regulated in the preeclampsia placenta and serum.

4. Findings indicate that variants in interleukin 10 (IL-10) promoter gene were not only associated with predisposition to chronic periodontitis but also affected the subgingival number of Aggregatibacter Actinomycetemcomitans in a Chinese Han population.

5. IL-6 rs1800796, IL-8 rs4073, IL-10 rs1800871, IL-10 rs1800872 and IL-10 rs1800896 polymorphisms may serve as genetic biomarkers of gastric cancer in Asians.

6. TBL is associated with significantly diminished plasma and elevated LN culture supernatant levels of most of the IL-10 family cytokines.

7. Neither HIIT nor MICT altered levels of circulating IL10, IL6, or TNFalpha.

8. A significant difference in the frequency of IL-10+434T and +504G alleles was found between Tubulointerstitial nephritis /tubulointersititial nephritis and uveitis patients and control population. Genotype -2849TT was more frequently present in patients with TINU syndrome than in the reference subjects.

9. IL-10 rs1800896 polymorphisms was associated with rheumatoid arthritis clinical severity.

10. In conclusion, this study revealed the crucial calcium signaling pathway triggered by HIV-1 gp120 to control the production of these two cytokines: TNF-alpha and IL-10.

11. IL-10 can inhibit the early phase of adipogenesis via suppressing Wnt5a signaling pathway in 3T3-L1 preadipocytes.

12. Ascl2 could inhibit Th17 differentiation and restrained their pathogenicity via facilitating IL-10 production.

13. Enhanced HO-1 expression restored the function of Tregs from vitiligo patients by up-regulating IL-10 expression.

14. The GG genotype of IL-10 rs3021094 was correlated with a higher risk of low responsiveness to HBV vaccination in Chinese infants of HBsAg(+)/HBeAg(-) mothers.

15. IL-35-producing B cells may play a regulatory role during MTB infection by producing IL-10.

16. Those who had top quartile concentrations of IL-4 and/or IL-10 on postnatal days 21 and/or 28 were more likely than their peers to have low scores on components of the NEPSY-II.

17. The results of our meta-analysis demonstrate that INTERLEUKIN 10 rs1800872 is associated with periodontitis susceptibility in Caucasians and Asians. Moreover, A allele, AA genotype, CC genotype may be closely associated with chronic periodontitis (CP), while A allele, AA genotype may be closely associated with aggressive periodontitis (AgP).

18. The TNF-alpha G-308A polymorphism independently associated with DBP, cholesterol, triglyceride, LDL, TNF-alpha and IL-10 levels.

19. IL-10-positive B cells from unstimulated samples represented approximately 2% of all B cells in healthy individuals.

20. The authors found that CC genotype carriage may be associated with decreased risk of Ischemic Stroke in Chinese Han Population. IL-10 -819 C>T may be an independent protective factor for Ischemic Stroke in Han group.

Mouse (Murine) Interleukin 10 (IL10) Interaktionspartner

1. myeloid-derived suppressor cells -IL-10-STAT3-DNMT3b-IRF8 pathway as a link between chronic inflammation and colon cancer initiation.

2. Literature review explains how anti-inflammatory cytokine IL-10 limits expansion of tissue lesions during chronic encephalomyelitis induced by neurotropic mouse hepatitis virus (MHV) without affecting viral persistence.

3. An increase in IL-10 production has an impact early but not later after infection.

4. Both intravenous and inhalational beta2AR agonists exert a cardioprotective effect against IRI by activating the anti-inflammatory beta2AR-IL-10 pathway.

5. CD69 is important to the suppressive function of Tregs by promoting IL-10 production.

6. cells expressing or dependent on Batf3 are required for IL-18-inducing IL-10 production observed in infected mice.

7. the data indicate that the clinical improvement reported in DSS-treated infected mice was accompanied by the lower production of Th1/Th2/Th17 pro-inflammatory cytokines, stimulation of IL-10, and induction of mucosal repair mechanisms.

8. These data suggest IFNg is up-regulated by pFUS and after i.v.-infused Mesenchymal stromal cell (MSC) home to pFUS-treated kidneys, IFNg stimulates additional IL-10 production by MSC to improve acute kidney injury (AKI).

9. IL-10 is required for the anti-arthritic effects of Schistosoma mansoni for down-regulation of the arthritis severity

10. model supports the hypothesis that recoverin-specific T cell responses are major drivers of autoimmune retinopathy pathogenesis and that IL-10 is an important factor in protection

11. The ICOS deficiency does not impair induction of IL-10 by intestinal CD4 T cells but, instead, triggers substantial reductions in gut-resident and peripherally derived Foxp3(+) Treg cells.

12. IL-10 plays a previously unrecognized stimulatory role on CD8(+) T cells.

13. AIF1 silencing in dendritic cells robustly expanded IL-10 producing CD8(+) CD122(+) PD-1(+) regulatory T cells.

14. The data demonstrate that endogenous IL-10 is critical in the maintenance of immune tolerance but exogenous administration of IL-10 exacerbates liver inflammation and fibrosis.

15. Infiltrating monocytes were identified as main IL-10 producers.

16. Results provide evidence that PIBF containing extracellular vesicles from mouse embryos alter IL-10 expression of mouse peripheral lymphocytes.

17. IL10 may be essential in lenalidomide-ameliorated experimental autoimmune encephalomyelitis.

18. Findings reveal a critical role for ADRB2 signaling in controlling inflammation through the rapid induction of IL-10. Findings provide a fundamental insight into how the sympathetic nervous system controls a critical facet of immune function through ADRB2 signaling.

19. Our data, therefore, establish that IL-10 signaling can directly control Th17 differentiation in CD4+ T cells via the IL-10Ra.

20. This effect is associated with an increased population of IL-10-secreting immune cells.

Cow (Bovine) Interleukin 10 (IL10) Interaktionspartner

1. Studied expression of Interleukin 10 (IL-10) in blood and milk samples of 25 healthy and 25 mastitic cows. Found IL-10 expression to be significantly higher in the blood and milk samples of mastitic cows compared to the healthy ones.

2. This study seems to indicate that PGE2 in cattle does not produce an anti-inflammatory effect by increasing the synthesis of IL-10.

3. IL-10 mRNA expression increased on day 8 in the mononuclear leukocytes of pregnant cows. In a cell culture experiment, interferon-tau stimulated stimulated IL-10 mRNA expression in mononuclear leukocytes.

4. Bovine IL-10 potently inhibits the activation of human myeloid cells in response to toll like receptor activation.

5. Levels in milk are altered in the presence of bacteria.

6. Monocytes obtained from cows with subclinical infection with MAP had upregulated expression of IL-10 and SOCS-3, which may have attenuated the capacity of mononuclear phagocytes to initiate inflammatory and adaptive immune responses.

Horse (Equine) Interleukin 10 (IL10) Interaktionspartner

1. The ability of an EHV-1 isolate to down-regulate IL-10 production might contribute to increased local inflammation and a higher risk for neurological manifestation of the disease after infection with Ab4.

2. The data suggested in foals there is an impaired Th2 response, the immune response is Th1 biased, interferon-gamma production is qualitatively similar to adult horses, and regulatory IL-10 production by T cells is mature.

3. serum IL-6:IL-10 ratio is likely to provide a valuable prognosticator for neonatal septicemia

4. The effect of clenbuterol on cytokine metabolism in the peripheral white blood cells in those horses with small airway diseases that have been exposed to lipopolysaccharides is reported.

5. The contribution of bronchial epithelium to airway inflammation, with focus on mRNA and protein expression of IL-6, IL-10 and TNF-alpha, in horses with recurrent airway obstruction during exacerbation and in remission is reported.

Guinea Pig Interleukin 10 (IL10) Interaktionspartner

1. The complete open reading frame consists of 537 base pairs which encodes a protein of 179 amino acids. This cDNA sequence exhibited 87% homology with human IL-10.

Rabbit Interleukin 10 (IL10) Interaktionspartner

1. Single nucleotide polymorphisms on exon 3 were significantly associated with immune traits.

2. ICAM1 and IL10 were upregulated in ventilator-induced lung injury. Nuclear transcription factor AP-1 may be responsible for this upregulation.

Pig (Porcine) Interleukin 10 (IL10) Interaktionspartner

1. In contrast to lung tissue, in which Actinobacillus pleuropneumoniae (APP) presence was associated with a pronounced pro-inflammatory character, APP presence in the tonsils elicited an increased IL-10 expression.

2. The PRRSV vaccination induced higher levels of IL-10 expression in the first week and this may be why the CSFV vaccination is immunosuppressed.

3. These data indicate that the type 2 porcine reproductive and respiratory syndrome virus N protein plays an important role in IL-10 induction and the N-N non-covalent domain is associated with this activity.

4. The effects of semen, spermatozoa in extender, or extender alone on the expression of TGF-beta1, IL-10, and IL-6 in ovarian follicles are reported.

5. Prostaglandin E2 potentiates mesenchymal stem cell-induced IL-10+IFN-gamma+CD4+ regulatory T cells to control transplant arteriosclerosis.

6. Porcine reproductive and respiratory syndrome virus strain CH-1a could significantly up-regulate IL-10 production through p38 MAPK activation.

7. Boar seminal plasma contained TGF- beta1 and IL-10 but with high individual variation.

8. Changes in interleukin-10 mRNA expression are predictive for 9-day survival of pigs in an emergency preservation and resuscitation model.

9. These results suggest that TNF-alpha and IL-10, but not IL-6, are involved in the late reparatory phases of the experimental disk lesion.

10. The present study shows that elevated levels of serum CRP and IL-10 were associated with porcine circovirus type 2-infected piglets that subsequently developed severe PMWS.(postweaning multisystemic wasting syndrome)

11. Subclinically porcine circovirus type 2 (PCV2)-infected pigs developed a transient PCV2-specific IL-10 response during the viremic phase of infection which coincided with the inversion of the IgM/IgG ratio.

12. Twenty one polymorphisms in the IL10 gene have been found, including single nucleotide polymorphisms and insertion deletion polymorphisms. The chromosomal location has been mapped by FISH and radiation hybrid mapping.

13. findings show that Brachyspira hyodysenteriae inoculation induced production of systemic levels of IL-1beta during the dysentery period and increased levels of IL-10 coincided with recovery from dysentery

Rhesus Monkey Interleukin 10 (IL10) Interaktionspartner

1. IL-10 produced during the immune response to malaria in this model contributes to suppression of mucosal inflammatory responses to invasive NTS, which may contribute to differences in the clinical presentation of NTS infection in the setting of malaria.

2. Findings demonstrate that internalization of IL-10R with the resultant impact on IL-10 signaling and dysregulation of the IL-10-mediated anti-inflammatory responses might play a crucial role in epithelial cell damage and subsequent simian immunodeficiency virus pathogenesis.

3. IL-10 plays a crucial role in maintaining mucosal homeostasis by regulating mucosal IFNgamma and TNFalpha cytokine production.