IL-10 Proteine (IL10)

Human Interleukin 10 (IL10) Interaktionspartner

1. Although IL-10 promoter polymorphisms are not associated with P. falciparum and S. haematobium co-infection, variant -1082G/A and haplotype GCC (zeige GUCY2C Proteine) are associated with malaria, whereas the IL-10 haplotypes GCC (zeige GUCY2C Proteine) and GTA are associated with schistosomiasis.

2. high IL-10 in rheumatoid arthritis is associated with increased depressive symptoms

3. TNF-alpha (zeige TNF Proteine) and IL-10 treatment can affect the expression of ICAM-1 (zeige ICAM1 Proteine) and CD31 (zeige HBA1 Proteine) in human coronary artery endothelial cells.

4. besides the NF-kappaB pathway, the mechanism of action of FGF-21 was observed to involve the elevation of IL-10 in the ERK1/2 pathway.

5. meta-analysis strongly suggests that the IL10 rs1800896, rs1800871, and rs1800872 polymorphisms are not associated with the risk of autoimmune liver disease

6. The IL-1b+3954 C/T polymorphism significantly increases RAS risk. In addition, the IL-10-1082 G/A polymorphism provided protective effects for RAS in the Asian population

7. Single nucleotide polymorphisms (SNPs) rs12979860 and rs8099917 (IL28B (zeige IL28B Proteine)) and rs1800896, rs1800871, and rs1800872 (IL10) are related to treatment outcome, but previous studies clustered nonresponse and relapse patients.Frequency of rs12979860 and rs8099917 is different between relapsers and nonresponders, but similar between relapsers and responders

8. The aim of this study was to explore the possible correlations of serum interleukins and soluble ST2 (zeige SULT2A1 Proteine) (sST2 (zeige SSTR2 Proteine)) protein with clinical features and inflammatory cytokines in rheumatoid arthritis (RA) patients.

9. Anti-inflammatory cytokines, IL-10 and TGF-beta1 (zeige TGFB1 Proteine), are not upregulated in the serum of patients with juvenile idiopathic arthritis.

10. The current study highlights the possible involvement of the IL-2 (zeige IL2 Proteine)-330T/G Single Nucleotide Polymorphism in susceptibility to B (zeige TDO2 Proteine)-Cell Non-Hodgkin Lymphoma . Moreover, IL-10-1082A/G is not a molecular susceptibility marker for B-Cell Non-Hodgkin Lymphoma in Egyptians.

Mouse (Murine) Interleukin 10 (IL10) Interaktionspartner

1. a regulatory loop in which IL-10 directly restricts CD8 (zeige CD8A Proteine)(+) T cell activation and function through modification of cell surface glycosylation allowing the establishment of chronic infection.

2. genome-wide knockdown of 19 ribosomal proteins resulted in decreased IL-10 and increased TNF-alpha (zeige TNF Proteine) production.

3. YB-1 (zeige YBX1 Proteine) orchestrates onset and resolution of renal inflammation via IL-10 gene regulation.

4. this study demonstrates IL-10 production and T cell-suppressive capacity in B cell subsets from atherosclerotic apoE (zeige APOE Proteine) (-/-) mice

5. IL-10 Knock out-Endothelial progenitor cell-Exosomes were highly enriched in microRNAs and proteins that promote inflammation and apoptosis and inhibit angiogenesis.

6. we showed the IL-10 expression of the pyramidal neurons in CA2 (zeige CA2 Proteine) and CA3 (zeige CA3 Proteine) subregions, for the first time in the world, after infection with the Mu-3 virus

7. These data indicate that CD4 (zeige CD4 Proteine)(+) follicular regulatory T (Tfr (zeige TFRC Proteine)) cells play a multifaceted role in the fine-tuning of the germinal center response and identify IL-10 as an important mediator by which Tfr (zeige TFRC Proteine) cells support the germinal center reaction

8. Decreased interleukin-10 (IL-10) expression was found in the hippocampus of the stressed mice, while no differences in pro-inflammatory cytokine expression and tryptophan (TRYP), kynurenine (KYN) or 3-hydroxy kynurenine (3-HK) levels were found.

9. HBV-specific CD8 (zeige CD8A Proteine)(+) T cells produce IL-10 upon antigen recognition and that this cytokine enhances CD8 (zeige CD8A Proteine)(+) T cell survival.

10. Novel regulatory T-cells that are induced by B cells and do not express Foxp3 (zeige FOXP3 Proteine) and IL-10 alleviate intestinal inflammation in vivo.

Cow (Bovine) Interleukin 10 (IL10) Interaktionspartner

1. Studied expression of Interleukin 10 (IL-10) in blood and milk samples of 25 healthy and 25 mastitic cows. Found IL-10 expression to be significantly higher in the blood and milk samples of mastitic cows compared to the healthy ones.

2. This study seems to indicate that PGE2 in cattle does not produce an anti-inflammatory effect by increasing the synthesis of IL-10.

3. IL-10 mRNA expression increased on day 8 in the mononuclear leukocytes of pregnant cows. In a cell culture experiment, interferon-tau stimulated stimulated IL-10 mRNA expression in mononuclear leukocytes.

4. Bovine IL-10 potently inhibits the activation of human myeloid cells in response to toll (zeige TLR4 Proteine) like receptor activation.

5. Monocytes obtained from cows with subclinical infection with MAP had upregulated expression of IL-10 and SOCS-3 (zeige SOCS3 Proteine), which may have attenuated the capacity of mononuclear phagocytes to initiate inflammatory and adaptive immune responses.

Horse (Equine) Interleukin 10 (IL10) Interaktionspartner

1. The ability of an EHV-1 isolate to down-regulate IL-10 production might contribute to increased local inflammation and a higher risk for neurological manifestation of the disease after infection with Ab4.

2. The data suggested in foals there is an impaired Th2 response, the immune response is Th1 (zeige TH1L Proteine) biased, interferon-gamma (zeige IFNG Proteine) production is qualitatively similar to adult horses, and regulatory IL-10 production by T cells is mature.

3. serum IL-6 (zeige IL6 Proteine):IL-10 ratio is likely to provide a valuable prognosticator for neonatal septicemia

4. The contribution of bronchial epithelium to airway inflammation, with focus on mRNA and protein expression of IL-6 (zeige IL6 Proteine), IL-10 and TNF-alpha (zeige TNF Proteine), in horses with recurrent airway obstruction during exacerbation and in remission is reported.

Guinea Pig Interleukin 10 (IL10) Interaktionspartner

1. The complete open reading frame consists of 537 base pairs which encodes a protein of 179 amino acids. This cDNA sequence exhibited 87% homology with human IL-10.

Rabbit Interleukin 10 (IL10) Interaktionspartner

1. ICAM1 (zeige ICAM1 Proteine) and IL10 were upregulated in ventilator-induced lung injury. Nuclear transcription factor AP-1 (zeige JUN Proteine) may be responsible for this upregulation.

Pig (Porcine) Interleukin 10 (IL10) Interaktionspartner

1. The PRRSV vaccination induced higher levels of IL-10 expression in the first week and this may be why the CSFV vaccination is immunosuppressed.

2. These data indicate that the type 2 porcine reproductive and respiratory syndrome virus N protein plays an important role in IL-10 induction and the N-N non-covalent domain is associated with this activity.

3. The effects of semen, spermatozoa in extender, or extender alone on the expression of TGF-beta1 (zeige TGFB1 Proteine), IL-10, and IL-6 (zeige IL6 Proteine) in ovarian follicles are reported.

4. Prostaglandin E2 potentiates mesenchymal stem cell-induced IL-10+IFN-gamma (zeige IFNG Proteine)+CD4 (zeige CD4 Proteine)+ regulatory T cells to control transplant arteriosclerosis.

5. Porcine reproductive and respiratory syndrome virus strain CH-1a could significantly up-regulate IL-10 production through p38 MAPK (zeige MAPK14 Proteine) activation.

6. Boar seminal plasma contained TGF- beta1 (zeige TGFB1 Proteine) and IL-10 but with high individual variation.

7. Changes in interleukin-10 mRNA expression are predictive for 9-day survival of pigs in an emergency preservation and resuscitation model.

8. These results suggest that TNF-alpha (zeige TNF Proteine) and IL-10, but not IL-6 (zeige IL6 Proteine), are involved in the late reparatory phases of the experimental disk lesion.

9. The present study shows that elevated levels of serum CRP (zeige CRP Proteine) and IL-10 were associated with porcine circovirus type 2-infected piglets that subsequently developed severe PMWS.(postweaning multisystemic wasting syndrome)

10. Subclinically porcine circovirus type 2 (PCV2)-infected pigs developed a transient PCV2-specific IL-10 response during the viremic phase of infection which coincided with the inversion of the IgM/IgG ratio.

Rhesus Monkey Interleukin 10 (IL10) Interaktionspartner

1. IL-10 produced during the immune response to malaria in this model contributes to suppression of mucosal inflammatory responses to invasive NTS (zeige NTS Proteine), which may contribute to differences in the clinical presentation of NTS (zeige NTS Proteine) infection in the setting of malaria.

2. Findings demonstrate that internalization of IL-10R with the resultant impact on IL-10 signaling and dysregulation of the IL-10-mediated anti-inflammatory responses might play a crucial role in epithelial cell damage and subsequent simian immunodeficiency virus pathogenesis.

3. IL-10 plays a crucial role in maintaining mucosal homeostasis by regulating mucosal IFNgamma and TNFalpha (zeige TNF Proteine) cytokine production.