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IL-10/JAK1 signaling might be a potential therapeutic target for NSCLC treatment.
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Significantly higher levels of cecal and colonic iNos expression and gammaH2AX-positive epithelial cells (a biomarker for double-strand DNA breaks [DSB]) in Hh-infected Rag2Il10gpt males vs. Hh-infected females were noted.
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IL10 expression was down-regulated in the preeclampsia placenta and serum.
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Findings indicate that variants in interleukin 10 (IL-10) promoter gene were not only associated with predisposition to chronic periodontitis but also affected the subgingival number of Aggregatibacter Actinomycetemcomitans in a Chinese Han population.
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IL-6 rs1800796, IL-8 rs4073, IL-10 rs1800871, IL-10 rs1800872 and IL-10 rs1800896 polymorphisms may serve as genetic biomarkers of gastric cancer in Asians.
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TBL is associated with significantly diminished plasma and elevated LN culture supernatant levels of most of the IL-10 family cytokines.
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Neither HIIT nor MICT altered levels of circulating IL10, IL6, or TNFalpha.
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A significant difference in the frequency of IL-10+434T and +504G alleles was found between Tubulointerstitial nephritis /tubulointersititial nephritis and uveitis patients and control population. Genotype -2849TT was more frequently present in patients with TINU syndrome than in the reference subjects.
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IL-10 rs1800896 polymorphisms was associated with rheumatoid arthritis clinical severity.
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In conclusion, this study revealed the crucial calcium signaling pathway triggered by HIV-1 gp120 to control the production of these two cytokines: TNF-alpha and IL-10.
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IL-10 can inhibit the early phase of adipogenesis via suppressing Wnt5a signaling pathway in 3T3-L1 preadipocytes.
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Ascl2 could inhibit Th17 differentiation and restrained their pathogenicity via facilitating IL-10 production.
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Enhanced HO-1 expression restored the function of Tregs from vitiligo patients by up-regulating IL-10 expression.
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The GG genotype of IL-10 rs3021094 was correlated with a higher risk of low responsiveness to HBV vaccination in Chinese infants of HBsAg(+)/HBeAg(-) mothers.
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IL-35-producing B cells may play a regulatory role during MTB infection by producing IL-10.
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Those who had top quartile concentrations of IL-4 and/or IL-10 on postnatal days 21 and/or 28 were more likely than their peers to have low scores on components of the NEPSY-II.
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The results of our meta-analysis demonstrate that INTERLEUKIN 10 rs1800872 is associated with periodontitis susceptibility in Caucasians and Asians. Moreover, A allele, AA genotype, CC genotype may be closely associated with chronic periodontitis (CP), while A allele, AA genotype may be closely associated with aggressive periodontitis (AgP).
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The TNF-alpha G-308A polymorphism independently associated with DBP, cholesterol, triglyceride, LDL, TNF-alpha and IL-10 levels.
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IL-10-positive B cells from unstimulated samples represented approximately 2% of all B cells in healthy individuals.
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The authors found that CC genotype carriage may be associated with decreased risk of Ischemic Stroke in Chinese Han Population. IL-10 -819 C>T may be an independent protective factor for Ischemic Stroke in Han group.