IL-10 Proteine (IL10)

Human Interleukin 10 (IL10) Interaktionspartner

1. We have identified rs1800896 (or a variant in strong LD with it) as the underlying causal variant within the IL10 locus and disclosed the suppression of immune responses to Aspergillus fumigatus as the primary mechanism explaining the increased susceptibility to infection.

2. An increasing number of studies suggest that differential expression of anti-inflammatory cytokines (IL-4, Il-10, TGFB1) occurs in women with endometriosis. (Review)

3. Highlighting the role of IL-10 cytokine in the pathogenesis of psoriasis will help in the development of psoriasis management

4. The study found no significant differences between Takayasu arteritis and healthy controls in the frequency of any of the variations in the SNPs of IL-6 and IL-10 genes. The expression levels of both cytokines were associated with the disease status, indicating that they may serve as potential biomarkers for monitoring disease activity.

5. hypermethylation of promoter region was the principal defect for the IL-10 mRNA low expression in patients with Behcet's disease.

6. siRNAs for CD5 or for TRPC1 inhibit IL-10 production.

7. this study shows that genetic polymorphisms in IL-10 are associated with an increased risk of cervical cancer in Chinese women

8. The logistic regression model emphasized the performance of FcgammaRI, FcgammaRII and IL-10 as robust predictive biomarkers for post-therapeutic cicatrization during cutaneous leishmaniasis.

9. cytokines up-regulate CX3CR1 expression on human monocytes by different intracellular mechanisms.

10. Both IL-10 and HOXA10 levels in the endometrium are significantly reduced in women with adenomyosis.

11. The rs1800871 polymorphism of Il-10 was significantly correlated with Diabetes Mellitus (DM) in Caucasians, the rs1800872 polymorphism was significantly correlated with DM in Asians, and the rs1800896 polymorphism was significantly correlated with DM in both Caucasians and Asians.

12. a CXCR5(-)CXCR3(+) programmed death 1 (PD1)(hi)CD4(+) helper T cell population of individuals with proliferative lupus nephritis produce interleukin-10 (IL-10) and accumulate mitochondrial reactive oxygen species as the result of reverse electron transport fueled by succinate.

13. IL-10-1082 A/G (rs1800896) G allele is associated with a decreased risk of developing premature coronary artery disease.

14. genotype of il10 in patients did not corelate with chronic graft versus host disease (cGVHD) and 1 year transplantation-related mortality (TRM). In cases who received hematopoietic stem cell transplantation (HSCT) of donors with AA genotype, the liver acute GVHD rate was higher than that in cases who received HSCT of donors with AC and CC genotype

15. the immune response in Mansonella ozzardi infection is modulated by IL-6/IL-10 axis.

16. patients with severe chronic obstructive pulmonary disease can exhibit compromised "inflammatory status", characterized by higher IL6, IL-6/IL-10 ratio and lower IL-10 concentration.

17. a significant association between 1082 A/G (rs1800896) polymorphism and acute pancreatitis risk (Meta-Analysis)

18. CPB2 positively correlates with IL10 mRNA expression, incidence of CD14(+) cells and lymphovascular invasion in inflammatory breast cancer (IBC) patients. IL-10 stimulated CPB2 expression in Triple negative-IBC cell line suggests a relevant role of CPB2 in the aggressive phenotype of IBC.

19. Preferential expression of low C-C chemokine receptor 1 (CCR1) and interleukin-10 (IL-10) was found in M2 macrophages (Mphi) compared with M1 Mphi.

20. Carriers of A-allele genotypes of the IL10 -1080A/G SNP had significantly lower CD83+ cells (p = 0.046) in the tumor invasive margin. The T-allele of the TGFB1 -509C/T SNP might be a protective factor for development of CRC, although, in the course of the disease, this variant allele might be associated with more unfavorable prognosis of the patients.

Mouse (Murine) Interleukin 10 (IL10) Interaktionspartner

1. These data suggest a potent regulatory role of IL-10 in the cross-reactive memory response to the infection with heterologous Plasmodium parasites leading to the inhibition of the protective immunity and pathogenesis.

2. B cells are the major producers of IL-10 in-vivo. In regulatory B cells, BATF, IFN regulatory factor, and IRF-8 transcription factors were recruited and bound to AP1-IRF-composite elements of il12a, ebi3, and/or il10 loci.

3. IL-10 can directly alter gonadotropin-releasing hormone neuron firing and induce ERK1/2 phosphorylation

4. Incorporation of IL-10 blocking agents may enhance current therapeutic regimens for CLL by potentiating host antitumor immune response.

5. Genetic deletion of 4E-BP1/2 in macrophages increased endogenous IL-10.

6. Resolution of inflammation-induced depression is an active process requiring T lymphocytes acting via an IL-10 dependent pathway in the brain.

7. commensal bacteria influence STING signaling predominantly in mononuclear phagocytes to produce both pro-inflammatory cytokines as well as anti-inflammatory IL-10.

8. The functional shortage of NK cells and inappropriate expression of IL10 result in the susceptibility to mouse cytomegalovirus in BALB/c mice.

9. IL-10-producing CD4(+) T cells are phenotypically and functionally heterogeneous.

10. Despite being coexpressed, IL-10 and IL-24 are independently regulated by different type I IFN receptor signaling pathways.

11. L-EVs were effective at inhibiting OVA peptide-specific CD4(+) T cell proliferation in a TGF-beta1- and IL-10-dependent manner.

12. CD103(+) cDCs counterregulated CD11b(+) cDC-mediated Th1 activation directly by producing the immune-suppressive cytokine IL-10.

13. Locus-specific reversible DNA demethylation may serve as a threshold platform to control transient Il-10 gene expression.

14. IL-10-induced STAT3 increases S1pr1 expression.

15. IL-10 induction in B cells was regulated by an ERK1/2- and p90 ribosomal S6 kinase-dependent mechanism, unlike in macrophages in which p90 ribosomal S6 kinase was not required.

16. glycine exposure enhanced the mRNA levels of adipose-derived adiponectin and IL-10 without affecting adipogenesis and lipolysis in 3T3-L1 adipocytes.

17. Interleukin 10 suppresses lysosome-mediated killing of Brucella abortus in cultured macrophages

18. Mice lacking IL-10 have increased energy expenditure and adipose thermogenesis. IL-10 affects chromatin structure and C/EBPbeta and ATF occupancy at thermogenic genes.

19. G protein-coupled receptor 39 exhibits an anti-inflammatory activity by enhancing IL-10 production from macrophages

20. our results provide direct evidence that the capacity of NK cells to secrete IL-10 is required to maintain the successful "innate" modulation of DC phenotype in the gravid uterus.

Cow (Bovine) Interleukin 10 (IL10) Interaktionspartner

1. Studied expression of Interleukin 10 (IL-10) in blood and milk samples of 25 healthy and 25 mastitic cows. Found IL-10 expression to be significantly higher in the blood and milk samples of mastitic cows compared to the healthy ones.

2. This study seems to indicate that PGE2 in cattle does not produce an anti-inflammatory effect by increasing the synthesis of IL-10.

3. IL-10 mRNA expression increased on day 8 in the mononuclear leukocytes of pregnant cows. In a cell culture experiment, interferon-tau stimulated stimulated IL-10 mRNA expression in mononuclear leukocytes.

4. Bovine IL-10 potently inhibits the activation of human myeloid cells in response to toll like receptor activation.

5. Levels in milk are altered in the presence of bacteria.

6. Monocytes obtained from cows with subclinical infection with MAP had upregulated expression of IL-10 and SOCS-3, which may have attenuated the capacity of mononuclear phagocytes to initiate inflammatory and adaptive immune responses.

Horse (Equine) Interleukin 10 (IL10) Interaktionspartner

1. The ability of an EHV-1 isolate to down-regulate IL-10 production might contribute to increased local inflammation and a higher risk for neurological manifestation of the disease after infection with Ab4.

2. The data suggested in foals there is an impaired Th2 response, the immune response is Th1 biased, interferon-gamma production is qualitatively similar to adult horses, and regulatory IL-10 production by T cells is mature.

3. serum IL-6:IL-10 ratio is likely to provide a valuable prognosticator for neonatal septicemia

4. The effect of clenbuterol on cytokine metabolism in the peripheral white blood cells in those horses with small airway diseases that have been exposed to lipopolysaccharides is reported.

5. The contribution of bronchial epithelium to airway inflammation, with focus on mRNA and protein expression of IL-6, IL-10 and TNF-alpha, in horses with recurrent airway obstruction during exacerbation and in remission is reported.

Guinea Pig Interleukin 10 (IL10) Interaktionspartner

1. The complete open reading frame consists of 537 base pairs which encodes a protein of 179 amino acids. This cDNA sequence exhibited 87% homology with human IL-10.

Rabbit Interleukin 10 (IL10) Interaktionspartner

1. Single nucleotide polymorphisms on exon 3 were significantly associated with immune traits.

2. ICAM1 and IL10 were upregulated in ventilator-induced lung injury. Nuclear transcription factor AP-1 may be responsible for this upregulation.

Pig (Porcine) Interleukin 10 (IL10) Interaktionspartner

1. In contrast to lung tissue, in which Actinobacillus pleuropneumoniae (APP) presence was associated with a pronounced pro-inflammatory character, APP presence in the tonsils elicited an increased IL-10 expression.

2. The PRRSV vaccination induced higher levels of IL-10 expression in the first week and this may be why the CSFV vaccination is immunosuppressed.

3. These data indicate that the type 2 porcine reproductive and respiratory syndrome virus N protein plays an important role in IL-10 induction and the N-N non-covalent domain is associated with this activity.

4. The effects of semen, spermatozoa in extender, or extender alone on the expression of TGF-beta1, IL-10, and IL-6 in ovarian follicles are reported.

5. Prostaglandin E2 potentiates mesenchymal stem cell-induced IL-10+IFN-gamma+CD4+ regulatory T cells to control transplant arteriosclerosis.

6. Porcine reproductive and respiratory syndrome virus strain CH-1a could significantly up-regulate IL-10 production through p38 MAPK activation.

7. Boar seminal plasma contained TGF- beta1 and IL-10 but with high individual variation.

8. Changes in interleukin-10 mRNA expression are predictive for 9-day survival of pigs in an emergency preservation and resuscitation model.

9. These results suggest that TNF-alpha and IL-10, but not IL-6, are involved in the late reparatory phases of the experimental disk lesion.

10. The present study shows that elevated levels of serum CRP and IL-10 were associated with porcine circovirus type 2-infected piglets that subsequently developed severe PMWS.(postweaning multisystemic wasting syndrome)

11. Subclinically porcine circovirus type 2 (PCV2)-infected pigs developed a transient PCV2-specific IL-10 response during the viremic phase of infection which coincided with the inversion of the IgM/IgG ratio.

12. Twenty one polymorphisms in the IL10 gene have been found, including single nucleotide polymorphisms and insertion deletion polymorphisms. The chromosomal location has been mapped by FISH and radiation hybrid mapping.

13. findings show that Brachyspira hyodysenteriae inoculation induced production of systemic levels of IL-1beta during the dysentery period and increased levels of IL-10 coincided with recovery from dysentery

Rhesus Monkey Interleukin 10 (IL10) Interaktionspartner

1. IL-10 produced during the immune response to malaria in this model contributes to suppression of mucosal inflammatory responses to invasive NTS, which may contribute to differences in the clinical presentation of NTS infection in the setting of malaria.

2. Findings demonstrate that internalization of IL-10R with the resultant impact on IL-10 signaling and dysregulation of the IL-10-mediated anti-inflammatory responses might play a crucial role in epithelial cell damage and subsequent simian immunodeficiency virus pathogenesis.

3. IL-10 plays a crucial role in maintaining mucosal homeostasis by regulating mucosal IFNgamma and TNFalpha cytokine production.