IL-10 Proteine (IL10)

Human Interleukin 10 (IL10) Interaktionspartner

1. LPS (zeige IRF6 Proteine) stimulation induced TLR4 (zeige TLR4 Proteine) expression and increased pigmentation. TLR4 (zeige TLR4 Proteine) expression was not detected after single-dose UVA or UVB treatment, but pigmentation increased. Repeated UV treatment induced TLR4 (zeige TLR4 Proteine) expression and increased pigmentation. LPS (zeige IRF6 Proteine) stimulation and repeated UV treatment increased IL-6 (zeige IL6 Proteine) secretion, and repeated UVB treatment increased IL-10 secretion.

2. findings support the hypothesis that the -1082A>G polymorphism in the IL10 gene might be associated with diabetic kidney disease in white Brazilians with type 2 diabetes.

3. This study showed that the activated FcgammaRII(low/-) B cells from HCC (zeige FAM126A Proteine) tumours, but not the resting FcgammaRII(high) B cells, without external stimulation suppress autologous tumour-specific cytotoxic T-cell immunity via IL-10 signals.

4. It was shown that the expression of CD274 (zeige CD274 Proteine), Il-10, and FOXP3 (zeige FOXP3 Proteine) was closely correlated with the clinical characteristics of laryngeal squamous cell carcinoma, including lymph node metastasis and prognosis.

5. IL-10 mRNA levels in peripheral B cells were significantly higher in lung cancer patients.A negative correlation was identified between miR (zeige MLXIP Proteine)-98 and IL-10 in peripheral B cells.

6. These findings added to the accumulating evidence that promoter haplotypes of IL-10 may be important modulators of the development of amnestic mild cognitive impairment

7. Findings suggest that the combinatorial complexity of TNFA (zeige TNF Proteine) and IL10 promoter polymorphisms impacts systemic lupus erythematosus susceptibility.

8. The combination of IL10 and DAO (zeige ABP1 Proteine) SNPs in a multivariate model did not alter the OR values.

9. The results indicate that IL10-1082 A/G polymorphism is associated with genetic susceptibility/predisposition to Rheumatoid arthritis in North Indian population.

10. IL-33 (zeige IL33 Proteine) increased IL-10 expression in MFCs via activating ERK 1 (zeige MAPK3 Proteine)/2 and STAT3 (zeige STAT3 Proteine), which subsequently promoted IL-10 transcription and thus contributed to the beneficial effects of IL-33 (zeige IL33 Proteine) on MFCs.

Mouse (Murine) Interleukin 10 (IL10) Interaktionspartner

1. genome-wide knockdown of 19 ribosomal proteins resulted in decreased IL-10 and increased TNF-alpha (zeige TNF Proteine) production.

2. YB-1 (zeige YBX1 Proteine) orchestrates onset and resolution of renal inflammation via IL-10 gene regulation.

3. this study demonstrates IL-10 production and T cell-suppressive capacity in B cell subsets from atherosclerotic apoE (zeige APOE Proteine) (-/-) mice

4. IL-10 Knock out-Endothelial progenitor cell-Exosomes were highly enriched in microRNAs and proteins that promote inflammation and apoptosis and inhibit angiogenesis.

5. we showed the IL-10 expression of the pyramidal neurons in CA2 (zeige CA2 Proteine) and CA3 (zeige CA3 Proteine) subregions, for the first time in the world, after infection with the Mu-3 virus

6. These data indicate that CD4 (zeige CD4 Proteine)(+) follicular regulatory T (Tfr (zeige TFRC Proteine)) cells play a multifaceted role in the fine-tuning of the germinal center response and identify IL-10 as an important mediator by which Tfr (zeige TFRC Proteine) cells support the germinal center reaction

7. Decreased interleukin-10 (IL-10) expression was found in the hippocampus of the stressed mice, while no differences in pro-inflammatory cytokine expression and tryptophan (TRYP), kynurenine (KYN) or 3-hydroxy kynurenine (3-HK) levels were found.

8. HBV-specific CD8 (zeige CD8A Proteine)(+) T cells produce IL-10 upon antigen recognition and that this cytokine enhances CD8 (zeige CD8A Proteine)(+) T cell survival.

9. Novel regulatory T-cells that are induced by B cells and do not express Foxp3 (zeige FOXP3 Proteine) and IL-10 alleviate intestinal inflammation in vivo.

10. Results provide evidence that macrophage IL-10 production is regulated by NLRP3 (zeige NLRP3 Proteine) and contributes to the pathophysiology of doxorubicin-induced cardiotoxicity independently of IL-1beta (zeige IL1B Proteine).

Cow (Bovine) Interleukin 10 (IL10) Interaktionspartner

1. Studied expression of Interleukin 10 (IL-10) in blood and milk samples of 25 healthy and 25 mastitic cows. Found IL-10 expression to be significantly higher in the blood and milk samples of mastitic cows compared to the healthy ones.

2. This study seems to indicate that PGE2 in cattle does not produce an anti-inflammatory effect by increasing the synthesis of IL-10.

3. IL-10 mRNA expression increased on day 8 in the mononuclear leukocytes of pregnant cows. In a cell culture experiment, interferon-tau stimulated stimulated IL-10 mRNA expression in mononuclear leukocytes.

4. Bovine IL-10 potently inhibits the activation of human myeloid cells in response to toll (zeige TLR4 Proteine) like receptor activation.

5. Monocytes obtained from cows with subclinical infection with MAP had upregulated expression of IL-10 and SOCS-3 (zeige SOCS3 Proteine), which may have attenuated the capacity of mononuclear phagocytes to initiate inflammatory and adaptive immune responses.

Horse (Equine) Interleukin 10 (IL10) Interaktionspartner

1. The ability of an EHV-1 isolate to down-regulate IL-10 production might contribute to increased local inflammation and a higher risk for neurological manifestation of the disease after infection with Ab4.

2. The data suggested in foals there is an impaired Th2 response, the immune response is Th1 (zeige TH1L Proteine) biased, interferon-gamma (zeige IFNG Proteine) production is qualitatively similar to adult horses, and regulatory IL-10 production by T cells is mature.

3. serum IL-6 (zeige IL6 Proteine):IL-10 ratio is likely to provide a valuable prognosticator for neonatal septicemia

4. The contribution of bronchial epithelium to airway inflammation, with focus on mRNA and protein expression of IL-6 (zeige IL6 Proteine), IL-10 and TNF-alpha (zeige TNF Proteine), in horses with recurrent airway obstruction during exacerbation and in remission is reported.

Guinea Pig Interleukin 10 (IL10) Interaktionspartner

1. The complete open reading frame consists of 537 base pairs which encodes a protein of 179 amino acids. This cDNA sequence exhibited 87% homology with human IL-10.

Rabbit Interleukin 10 (IL10) Interaktionspartner

1. ICAM1 (zeige ICAM1 Proteine) and IL10 were upregulated in ventilator-induced lung injury. Nuclear transcription factor AP-1 (zeige JUN Proteine) may be responsible for this upregulation.

Pig (Porcine) Interleukin 10 (IL10) Interaktionspartner

1. The PRRSV vaccination induced higher levels of IL-10 expression in the first week and this may be why the CSFV vaccination is immunosuppressed.

2. These data indicate that the type 2 porcine reproductive and respiratory syndrome virus N protein plays an important role in IL-10 induction and the N-N non-covalent domain is associated with this activity.

3. The effects of semen, spermatozoa in extender, or extender alone on the expression of TGF-beta1 (zeige TGFB1 Proteine), IL-10, and IL-6 (zeige IL6 Proteine) in ovarian follicles are reported.

4. Prostaglandin E2 potentiates mesenchymal stem cell-induced IL-10+IFN-gamma (zeige IFNG Proteine)+CD4 (zeige CD4 Proteine)+ regulatory T cells to control transplant arteriosclerosis.

5. Porcine reproductive and respiratory syndrome virus strain CH-1a could significantly up-regulate IL-10 production through p38 MAPK (zeige MAPK14 Proteine) activation.

6. Boar seminal plasma contained TGF- beta1 (zeige TGFB1 Proteine) and IL-10 but with high individual variation.

7. Changes in interleukin-10 mRNA expression are predictive for 9-day survival of pigs in an emergency preservation and resuscitation model.

8. These results suggest that TNF-alpha (zeige TNF Proteine) and IL-10, but not IL-6 (zeige IL6 Proteine), are involved in the late reparatory phases of the experimental disk lesion.

9. The present study shows that elevated levels of serum CRP (zeige CRP Proteine) and IL-10 were associated with porcine circovirus type 2-infected piglets that subsequently developed severe PMWS.(postweaning multisystemic wasting syndrome)

10. Subclinically porcine circovirus type 2 (PCV2)-infected pigs developed a transient PCV2-specific IL-10 response during the viremic phase of infection which coincided with the inversion of the IgM/IgG ratio.

Rhesus Monkey Interleukin 10 (IL10) Interaktionspartner

1. IL-10 produced during the immune response to malaria in this model contributes to suppression of mucosal inflammatory responses to invasive NTS (zeige NTS Proteine), which may contribute to differences in the clinical presentation of NTS (zeige NTS Proteine) infection in the setting of malaria.

2. Findings demonstrate that internalization of IL-10R with the resultant impact on IL-10 signaling and dysregulation of the IL-10-mediated anti-inflammatory responses might play a crucial role in epithelial cell damage and subsequent simian immunodeficiency virus pathogenesis.

3. IL-10 plays a crucial role in maintaining mucosal homeostasis by regulating mucosal IFNgamma and TNFalpha (zeige TNF Proteine) cytokine production.