IL-10 Proteine (IL10)

Human Interleukin 10 (IL10) Interaktionspartner

1. Results found that promoter polymorphisms of IL-10 have been significantly associated with intervertebral disc degeneration in Iranian population.

2. Study suggests that asthma is significantly associated with higher differentially methylated regions within region 3 of intron 4 of IL10.

3. The IL10 may function as a biomarker for immunoregulation in AFB1-exposed GD patients.

4. Low IL10 expression is associated with early stage invasive breast cancer.

5. Overall, there was no significant association between IL-10 -1082A>G polymorphism and breast cancer risk under all genetic models. Moreover, there was no significant association between the IL-10 -1082A>G polymorphism and breast cancer risk by ethnicity.

6. IL-10-producing Foxp3(neg) CD4(+) T cells have a unique transcriptional program, which goes beyond the regulation of IL-10 expression. Patients with inflammatory bowel disease demonstrate a deficiency in this specific regulatory T-cell subpopulation.

7. IL-10 attenuates the Neisseria meninigitidis-stimulated increase in MyD88-dependent pro-inflammatory cytokines

8. IL-10-1082G/A gene polymorphism is associated with recurrent oral ulcer (ROU) susceptibility. Individuals with G allele and GA genotype have a higher risk of ROU [meta-analysis]

9. the IL-10 expression level and the STAT3 activation level were significantly higher in MYD88 L265P mutant lymphomas than in MYD88 WT lymphomas.

10. Combined 2 Hz, 2 Hz/100 Hz acupuncture anesthesia need few anesthetic dosages of propofol and fentanyl to stabilise the patient's blood pressure and heart rate when intubated under general anesthesia; but combined 2 Hz acupuncture anesthesia can reduce IL-4 and IL-10 levels during surgery stress to a greater extent than the latter, and can effectively lower patients' serum IL-4, IL-10 expression after surgery.

11. The results indicated that people who carried CC genotype in rs1800872 of IL10 gene have an increasing risk of primary hepatic carcinoma.

12. These findings suggest that Foxp3(+) cells, IL-10 and IL-17 play important roles in the immunopathogenesis of cutaneous leishmaniasis and that these roles differ depending on the causal leishmania species and different body compartments.

13. here was no difference in devel-opment of diabetic nephropathy, retinopathy and polyneuropathy between the IL-10 polymorphism genotypes.

14. TGF-b, IL-10, and Foxp3 mRNA levels were significantly higher in patients with breast cancer than in healthy controls (P < 0.05). In summary, our results suggest that nutritional status, especially BMI, may strongly affect systematic immune function in patients with breast cancer

15. IL-10-592 (-590, -597) A allele and the associated AA genotype may be risk factors for the onset of peritonitis.

16. potential role for IL-10 in modulating an inflammatory response and lung function in agriculture-exposed persons

17. IL-10 suppresses TNF-alpha-induced expression of human aromatase gene in mammary adipose tissue.

18. Children with RSV infected had increased serum regulatory cytokine IL-10 and IL-35 concentrations. Elevated expression of IL-10 and IL-35 were contributed to protect hypoxia and reduce the severity of disease.

19. T lymphocyte immune imbalance was associated with obstructive sleep apnea (OSA), and IL-10 may play an important protective role in the pathogenesis of OSA in obese children

20. these findings suggest that impaired IL-10 production in response to microbial stimuli at birth may be associated with an increased risk of developing infantile atopic dermatitis, even in infants with early colonization of intestinal bifidobacteria

Mouse (Murine) Interleukin 10 (IL10) Interaktionspartner

1. IL-10-producing CD4(+) T cells are phenotypically and functionally heterogeneous.

2. Despite being coexpressed, IL-10 and IL-24 are independently regulated by different type I IFN receptor signaling pathways.

3. L-EVs were effective at inhibiting OVA peptide-specific CD4(+) T cell proliferation in a TGF-beta1- and IL-10-dependent manner.

4. CD103(+) cDCs counterregulated CD11b(+) cDC-mediated Th1 activation directly by producing the immune-suppressive cytokine IL-10.

5. Locus-specific reversible DNA demethylation may serve as a threshold platform to control transient Il-10 gene expression.

6. IL-10-induced STAT3 increases S1pr1 expression.

7. IL-10 induction in B cells was regulated by an ERK1/2- and p90 ribosomal S6 kinase-dependent mechanism, unlike in macrophages in which p90 ribosomal S6 kinase was not required.

8. glycine exposure enhanced the mRNA levels of adipose-derived adiponectin and IL-10 without affecting adipogenesis and lipolysis in 3T3-L1 adipocytes.

9. Interleukin 10 suppresses lysosome-mediated killing of Brucella abortus in cultured macrophages

10. Mice lacking IL-10 have increased energy expenditure and adipose thermogenesis. IL-10 affects chromatin structure and C/EBPbeta and ATF occupancy at thermogenic genes.

11. G protein-coupled receptor 39 exhibits an anti-inflammatory activity by enhancing IL-10 production from macrophages

12. our results provide direct evidence that the capacity of NK cells to secrete IL-10 is required to maintain the successful "innate" modulation of DC phenotype in the gravid uterus.

13. Restrictive IL-10 induction by an innocuous parainfluenza virus vector ameliorates nasal allergy.

14. a regulatory loop in which IL-10 directly restricts CD8(+) T cell activation and function through modification of cell surface glycosylation allowing the establishment of chronic infection.

15. genome-wide knockdown of 19 ribosomal proteins resulted in decreased IL-10 and increased TNF-alpha production.

16. YB-1 orchestrates onset and resolution of renal inflammation via IL-10 gene regulation.

17. this study demonstrates IL-10 production and T cell-suppressive capacity in B cell subsets from atherosclerotic apoE (-/-) mice

18. IL-10 Knock out-Endothelial progenitor cell-Exosomes were highly enriched in microRNAs and proteins that promote inflammation and apoptosis and inhibit angiogenesis.

19. we showed the IL-10 expression of the pyramidal neurons in CA2 and CA3 subregions, for the first time in the world, after infection with the Mu-3 virus

20. These data indicate that CD4(+) follicular regulatory T (Tfr) cells play a multifaceted role in the fine-tuning of the germinal center response and identify IL-10 as an important mediator by which Tfr cells support the germinal center reaction

Cow (Bovine) Interleukin 10 (IL10) Interaktionspartner

1. Studied expression of Interleukin 10 (IL-10) in blood and milk samples of 25 healthy and 25 mastitic cows. Found IL-10 expression to be significantly higher in the blood and milk samples of mastitic cows compared to the healthy ones.

2. This study seems to indicate that PGE2 in cattle does not produce an anti-inflammatory effect by increasing the synthesis of IL-10.

3. IL-10 mRNA expression increased on day 8 in the mononuclear leukocytes of pregnant cows. In a cell culture experiment, interferon-tau stimulated stimulated IL-10 mRNA expression in mononuclear leukocytes.

4. Bovine IL-10 potently inhibits the activation of human myeloid cells in response to toll like receptor activation.

5. Levels in milk are altered in the presence of bacteria.

6. Monocytes obtained from cows with subclinical infection with MAP had upregulated expression of IL-10 and SOCS-3, which may have attenuated the capacity of mononuclear phagocytes to initiate inflammatory and adaptive immune responses.

Horse (Equine) Interleukin 10 (IL10) Interaktionspartner

1. The ability of an EHV-1 isolate to down-regulate IL-10 production might contribute to increased local inflammation and a higher risk for neurological manifestation of the disease after infection with Ab4.

2. The data suggested in foals there is an impaired Th2 response, the immune response is Th1 biased, interferon-gamma production is qualitatively similar to adult horses, and regulatory IL-10 production by T cells is mature.

3. serum IL-6:IL-10 ratio is likely to provide a valuable prognosticator for neonatal septicemia

4. The effect of clenbuterol on cytokine metabolism in the peripheral white blood cells in those horses with small airway diseases that have been exposed to lipopolysaccharides is reported.

5. The contribution of bronchial epithelium to airway inflammation, with focus on mRNA and protein expression of IL-6, IL-10 and TNF-alpha, in horses with recurrent airway obstruction during exacerbation and in remission is reported.

Guinea Pig Interleukin 10 (IL10) Interaktionspartner

1. The complete open reading frame consists of 537 base pairs which encodes a protein of 179 amino acids. This cDNA sequence exhibited 87% homology with human IL-10.

Rabbit Interleukin 10 (IL10) Interaktionspartner

1. Single nucleotide polymorphisms on exon 3 were significantly associated with immune traits.

2. ICAM1 and IL10 were upregulated in ventilator-induced lung injury. Nuclear transcription factor AP-1 may be responsible for this upregulation.

Pig (Porcine) Interleukin 10 (IL10) Interaktionspartner

1. In contrast to lung tissue, in which Actinobacillus pleuropneumoniae (APP) presence was associated with a pronounced pro-inflammatory character, APP presence in the tonsils elicited an increased IL-10 expression.

2. The PRRSV vaccination induced higher levels of IL-10 expression in the first week and this may be why the CSFV vaccination is immunosuppressed.

3. These data indicate that the type 2 porcine reproductive and respiratory syndrome virus N protein plays an important role in IL-10 induction and the N-N non-covalent domain is associated with this activity.

4. The effects of semen, spermatozoa in extender, or extender alone on the expression of TGF-beta1, IL-10, and IL-6 in ovarian follicles are reported.

5. Prostaglandin E2 potentiates mesenchymal stem cell-induced IL-10+IFN-gamma+CD4+ regulatory T cells to control transplant arteriosclerosis.

6. Porcine reproductive and respiratory syndrome virus strain CH-1a could significantly up-regulate IL-10 production through p38 MAPK activation.

7. Boar seminal plasma contained TGF- beta1 and IL-10 but with high individual variation.

8. Changes in interleukin-10 mRNA expression are predictive for 9-day survival of pigs in an emergency preservation and resuscitation model.

9. These results suggest that TNF-alpha and IL-10, but not IL-6, are involved in the late reparatory phases of the experimental disk lesion.

10. The present study shows that elevated levels of serum CRP and IL-10 were associated with porcine circovirus type 2-infected piglets that subsequently developed severe PMWS.(postweaning multisystemic wasting syndrome)

11. Subclinically porcine circovirus type 2 (PCV2)-infected pigs developed a transient PCV2-specific IL-10 response during the viremic phase of infection which coincided with the inversion of the IgM/IgG ratio.

12. Twenty one polymorphisms in the IL10 gene have been found, including single nucleotide polymorphisms and insertion deletion polymorphisms. The chromosomal location has been mapped by FISH and radiation hybrid mapping.

13. findings show that Brachyspira hyodysenteriae inoculation induced production of systemic levels of IL-1beta during the dysentery period and increased levels of IL-10 coincided with recovery from dysentery

Rhesus Monkey Interleukin 10 (IL10) Interaktionspartner

1. IL-10 produced during the immune response to malaria in this model contributes to suppression of mucosal inflammatory responses to invasive NTS, which may contribute to differences in the clinical presentation of NTS infection in the setting of malaria.

2. Findings demonstrate that internalization of IL-10R with the resultant impact on IL-10 signaling and dysregulation of the IL-10-mediated anti-inflammatory responses might play a crucial role in epithelial cell damage and subsequent simian immunodeficiency virus pathogenesis.

3. IL-10 plays a crucial role in maintaining mucosal homeostasis by regulating mucosal IFNgamma and TNFalpha cytokine production.