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Human Polyclonal GJB1 Primary Antibody für IHC (p), WB - ABIN965915
Corcos, Lafrenière, Begy, Loch-Caruso, Willard, Glover: Refined localization of human connexin32 gene locus, GJB1, to Xq13.1. in Genomics 1992
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Cow (Bovine) Polyclonal GJB1 Primary Antibody für IHC, WB - ABIN2774855
Dagli, Yamasaki, Krutovskikh, Omori: Delayed liver regeneration and increased susceptibility to chemical hepatocarcinogenesis in transgenic mice expressing a dominant-negative mutant of connexin32 only in the liver. in Carcinogenesis 2004
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Rat (Rattus) Monoclonal GJB1 Primary Antibody für FACS, IF - ABIN5578830
Goodenough, Paul, Jesaitis: Topological distribution of two connexin32 antigenic sites in intact and split rodent hepatocyte gap junctions. in The Journal of cell biology 1988
Blocking of connexin32 or connexin43 (zeige GJA1 Antikörper) hemichannels decreased serum levels of pro-inflammatory cytokines, and reduced acetaminophen-induced liver injury.
The results of this study indicated that the Leu89Pro substitution in the second transmembrane domain of CX32 disrupts the trafficking of the protein, inhibiting the assembly of CX32 gap junctions, which in turn may result in peripheral neuropathy.
We show that the cell-surface and secreted isoforms of CSF-1 (zeige CSF1 Antikörper) have opposing effects on macrophage activation and disease progression in a mouse model of connexin32-deficientconnexin32-deficient mice
Results identify CSF-1 (zeige CSF1 Antikörper)-activated macrophages as crucial mediators of detrimental Schwann cell dedifferentiation in Cx32-deficient mice
Blockade of endothelial Cx32 increased tissue factor (zeige F3 Antikörper) expression induced by TNF-alpha (zeige TNF Antikörper) stimulation and cell-cell interaction via ICAM1 (zeige ICAM1 Antikörper). Direct Cx32-mediated interaction modulates TF expression in ECs during vascular inflammation.
These findings support a role for Cx32 in non-myelinating and regenerating populations of Schwann cells in normal axonal maintenance in re-myelination, and regeneration of peripheral nerve following injury
Connexin32 interacts with connexin26 (zeige GJB2 Antikörper) and the mitochondrial protein (zeige COX6B2 Antikörper), sideroflexin-1 (zeige SFXN1 Antikörper), at the plasma membrane forming a novel signaling nexus.
These results demonstrate that the incidence of hepatocellular carcinoma increases only in male Cx32KO mice, presumably due to enhanced tumor promotion and progression signals associated with Cx32 deficiency.
Cx32 is differentially phosphorylated and exists in a complex with SAP97 and CaM.
Cx32 therapy improves gap junctional conductance results in larger infarct size, and no antiarrhythmic efficacy.
Results show that the GJB1 (connexin 32; Cx32) mutants R75P, R75Q and R75W display variable structural conformation and dynamic behavior compared to the native protein.
Point mutation of GJB1 gene, encoding connexin 32, is associated with X-linked Charcot-Marie-Tooth disease.
Cx32 regulates the sensitivity of hepatocellular carcinoma cells to doxorubicin via the Src (zeige SRC Antikörper)/FAK (zeige PTK2 Antikörper) signaling pathway
Study verifies that Cx32 exerts an inhibitory effect on extrinsic apoptosis in cervical cancer (CaCx) cells, and suggests that Cx32 may regulate the progression and micro-environment of CaCx cells.
Cx32 is essential for cell-cell interactions that facilitate driving hESCs through hepatic-lineage maturation.
Study provides a novel mechanism for Cx32's anti-apoptotic effect and provides a reasonable explanation for the pro-tumor effect of Cx32 in human cervical cancer cells.
Genetic analysis revealed a total of 43 mutations including 6 novel mutations. Ten mutations were found from two or more unrelated families. p.V95M was most frequently observed. The frequency of CMTX1 was 9.6% of total Korean CMT family and was 14.8% when calculated within genetically identified cases
PBX1 (zeige PBX1 Antikörper) is one of the determinants in the Cx32 promoter targeting site, preventing further damage of gap junction protein in H. pylori-associated gastric carcinogenesis.
Study describes a novel mutation deleting entire P2 promoter of GJB1 gene in a single large family with X-linked Charcot-Marie-Tooth disease. Inheritance and phenotype of affected individuals had classical features of X linked peripheral neuropathy. This study affirms the role of P2 promoter being vital for Schwann cell function.
our results suggest that Cx32 inhibits Hepatocellular carcinoma (HCC (zeige FAM126A Antikörper)) invasion and metastasis through Snail (zeige SNAI1 Antikörper)-mediated EMT (zeige ITK Antikörper), Cx32 and this signaling pathway molecules may offer potential targets for HCC (zeige FAM126A Antikörper) cancer therapy
intermediate invasive status of bovine trophoblast is supported by the fact that trophoblast giant cells coexpress connexins (Cx)26 (zeige GJB2 Antikörper), Cx32, and Cx43 (zeige GJA1 Antikörper)
This gene encodes a member of the gap junction protein family. The gap junction proteins are membrane-spanning proteins that assemble to form gap junction channels that facilitate the transfer of ions and small molecules between cells. According to sequence similarities at the nucleotide and amino acid levels, the gap junction proteins are divided into two categories, alpha and beta. Mutations in this gene cause X-linked Charcot-Marie-Tooth disease, an inherited peripheral neuropathy. Alternatively spliced transcript variants encoding the same protein have been found for this gene.
, connexin 32
, gap junction protein, beta 1, 32kDa
, gap junction beta-1 protein
, gap junction membrane channel protein beta 1
, GAP junction 28 kDa liver protein
, gap junction protein, beta 1, 32 kD
, gap junction protein beta 1