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BRE Antikörper

(Brain and Reproductive Organ-Expressed (TNFRSF1A Modulator) (BRE))
Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integrity and modulating the E3 ubiquitin ligase activity of the BRCA1-BARD1 heterodimer. Probably also plays a role as a component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin (By similarity).

Häufig verwendete BRE Antikörper

Aktuelle Publikationen für unsere BRE Antikörper

Chan, Ching, To, Leung, Chen, Li, Lai, Tang, Shaw, Chan, James, Lai, Lim, Lee, Chui: "BRE is an antiapoptotic protein in vivo and overexpressed in human hepatocellular carcinoma." in: Oncogene, Vol. 27, Issue 9, pp. 1208-17, (2008) (PubMed).

Li, Ching, Chan, Chow, Lim, Ho, Ip, Wong, Lam, Lee, Chan, Chui: "A death receptor-associated anti-apoptotic protein, BRE, inhibits mitochondrial apoptotic pathway." in: The Journal of biological chemistry, Vol. 279, Issue 50, pp. 52106-16, (2004) (PubMed).

Dong, Hakimi, Chen, Kumaraswamy, Cooch, Godwin, Shiekhattar: "Regulation of BRCC, a holoenzyme complex containing BRCA1 and BRCA2, by a signalosome-like subunit and its role in DNA repair." in: Molecular cell, Vol. 12, Issue 5, pp. 1087-99, (2003) (PubMed).

Ching, Li, Li, Chan, Chan, Lim, Pang, Chui: "Expression of human BRE in multiple isoforms." in: Biochemical and biophysical research communications, Vol. 288, Issue 3, pp. 535-45, (2001) (PubMed).

Li, Yoo, Becker, Ali-Osman, Chan: "Identification of a brain- and reproductive-organs-specific gene responsive to DNA damage and retinoic acid." in: Biochemical and biophysical research communications, Vol. 206, Issue 2, pp. 764-74, (1995) (PubMed).

Aliase für BRE Antikörper

BRISC and BRCA1 A complex member 2 (babam2) Antikörper
BRISC and BRCA1 A complex member 2 (BABAM2) Antikörper
BRISC and BRCA1 A complex member 2 (Babam2) Antikörper
brain and reproductive organ-expressed (TNFRSF1A modulator) (BRE) Antikörper
BRISC and BRCA1 A complex member 2 L homeolog (babam2.L) Antikörper
6030405P19Rik Antikörper
AI429776 Antikörper
B830038C02Rik Antikörper
brcc4 Antikörper
BRCC4 Antikörper
brcc45 Antikörper
BRCC45 Antikörper
BRE Antikörper
im:7141046 Antikörper
LOC100231620 Antikörper
zgc:110368 Antikörper
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