XBP1 Antikörper

Produktnummer ABIN969462

Dieses Anti-XBP1-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von XBP1 in ELISA. Geeignet für Human. Dieses Primary Antibody wurde in 3+ Publikationen zitiert.

Kurzübersicht für XBP1 Antikörper (ABIN969462)

Target: XBP1 (X-Box Binding Protein 1 (XBP1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser XBP1 Antikörper ist unkonjugiert

Applikation: ELISA

Klon: 1C4

Produktdetails anti-XBP1 Antikörper

Verwendungszweck: XBP1 Antibody

Aufreinigung: Ascitic fluid

Immunogen: Purified recombinant fragment of human XBP1 expressed in E. Coli.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: ELISA: 1/10000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Referenzen für anti-XBP1 Antikörper (ABIN969462)

Martino, Olsen, Fulcher, Wolfgang, ONeal, Ribeiro: "Airway epithelial inflammation-induced endoplasmic reticulum Ca2+ store expansion is mediated by X-box binding protein-1." in: The Journal of biological chemistry, Vol. 284, Issue 22, pp. 14904-13, (2009) (PubMed).

Schardt, Weber, Eyholzer, Mueller, Pabst: "Activation of the unfolded protein response is associated with favorable prognosis in acute myeloid leukemia." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 15, Issue 11, pp. 3834-41, (2009) (PubMed).

Jiang, Yang, Thorne, Zhu, Hersey, Zhang: "Human melanoma cells under endoplasmic reticulum stress acquire resistance to microtubule-targeting drugs through XBP-1-mediated activation of Akt." in: Neoplasia (New York, N.Y.), Vol. 11, Issue 5, pp. 436-47, (2009) (PubMed).

Details zu XBP1

Target: XBP1 (X-Box Binding Protein 1 (XBP1))

Andere Bezeichnung: XBP1

Hintergrund: This gene encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. This gene product is a bZIP protein, which was also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. It may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator. It has been found that upon accumulation of unfolded proteins in the endoplasmic reticulum (ER), the mRNA of this gene is processed to an active form by an unconventional splicing mechanism that is mediated by the endonuclease inositol-requiring enzyme 1 (IRE1). The resulting loss of 26 nt from the spliced mRNA causes a frame-shift and an isoform XBP1(S), which is the functionally active transcription factor. The isoform encoded by the unspliced mRNA, XBP1(U), is constitutively expressed, and thought to function as a negative feedback regulator of XBP1(S), which shuts off transcription of target genes during the recovery phase of ER stress. A pseudogene of XBP1 has been identified and localized to chromosome 5.

Molekulargewicht: 28 kDa

Gen-ID: 7494

UniProt: P17861

Pathways: ER-Nucleus Signaling, Unfolded Protein Response