STAT5B Antikörper

Produktnummer ABIN969422

Produktdetails anti-STAT5B Antikörper

Target: STAT5B (Signal Transducer and Activator of Transcription 5B (STAT5B))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser STAT5B Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Aufreinigung: purified

Immunogen: Purified recombinant fragment of human STAT5B expressed in E. coli.

Klon: 5B3

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: ELISA: 1:10000, WB: 1:500 - 1:2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: 4°C, -20°C for long term storage

Details zu STAT5B

Target: STAT5B (Signal Transducer and Activator of Transcription 5B (STAT5B))

Andere Bezeichnung: STAT5B (STAT5B Produkte)

Synonyme: STAT5 antikoerper, stat5 antikoerper, STAT5A antikoerper, STAT5B antikoerper, signal transducer and activator of transcription 5B antikoerper, signal transducer and activator of transcription 5B S homeolog antikoerper, Signal transducer and activator of transcription 5B antikoerper, STAT5B antikoerper, Stat5b antikoerper, stat5b.S antikoerper, LOC490969 antikoerper, sta5b antikoerper, LOC100566752 antikoerper, LOC100052954 antikoerper

Hintergrund:

Description: The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL.

Aliases: STAT5, STAT5B

Molekulargewicht: 90 kDa

Gen-ID: 6777

HGNC: 6777

Pathways: JAK-STAT Signalweg, RTK Signalweg, Response to Growth Hormone Stimulus, C21-Steroid Hormone Metabolic Process, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, CXCR4-mediated Signaling Events, Activated T Cell Proliferation