IRAK4 Antikörper
(2 Referenzen)Kurzübersicht für IRAK4 Antikörper (ABIN969218)
Target
Alle IRAK4 Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
Klon
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Verwendungszweck
- IRAK4 Antibody
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Aufreinigung
- Ascitic fluid
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Immunogen
- Purified recombinant fragment of human IRAK4 expressed in E. Coli.
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Isotyp
- IgG1
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anti-Interleukin-1 Receptor-Associated Kinase 4 (IRAK4) (AA 189-427) antibody
IRAK4 Reaktivität: Human WB, ELISA, IHC (p), ICC, IHC (fro) Wirt: Kaninchen Polyclonal unconjugated
anti-Interleukin-1 Receptor-Associated Kinase 4 (IRAK4) (AA 1-220) antibodyIRAK4 Reaktivität: Human WB, IHC, IF Wirt: Kaninchen Polyclonal unconjugated
anti-Interleukin-1 Receptor-Associated Kinase 4 (IRAK4) (AA 5-36), (N-Term) antibodyIRAK4 Reaktivität: Human WB, IHC (p) Wirt: Kaninchen Polyclonal RB2347 unconjugated
anti-Interleukin-1 Receptor-Associated Kinase 4 (IRAK4) (N-Term) antibodyVerified IRAK4 Reaktivität: Human WB, ELISA, IHC, FACS, IF Wirt: Ziege Polyclonal unconjugated
anti-Interleukin-1 Receptor-Associated Kinase 4 (IRAK4) (AA 1-130) antibodyIRAK4 Reaktivität: Human WB, ELISA Wirt: Maus Monoclonal 2D3 unconjugated
anti-Interleukin-1 Receptor-Associated Kinase 4 (IRAK4) (pThr345) antibodyIRAK4 Reaktivität: Human, Maus, Ratte, Rind (Kuh), Schwein, Hund WB, IF (p), IHC (p) Wirt: Kaninchen Polyclonal unconjugated
anti-Interleukin-1 Receptor-Associated Kinase 4 (IRAK4) (AA 25-52), (N-Term) antibodyIRAK4 Reaktivität: Human WB Wirt: Kaninchen Polyclonal RB33094 unconjugated
anti-Interleukin-1 Receptor-Associated Kinase 4 (IRAK4) (AA 1-130) antibodyIRAK4 Reaktivität: Human WB, ELISA Wirt: Maus Monoclonal 1D4 unconjugated
anti-Interleukin-1 Receptor-Associated Kinase 4 (IRAK4) (AA 1-220) antibodyIRAK4 Reaktivität: Human WB, ELISA, IP Wirt: Kaninchen Polyclonal unconjugated
anti-Interleukin-1 Receptor-Associated Kinase 4 (IRAK4) (pThr345) antibodyIRAK4 Reaktivität: Human, Maus WB, ELISA, IF (p), IHC (p), IF (cc), IHC (fro) Wirt: Kaninchen Polyclonal unconjugated
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Applikationshinweise
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ELISA: 1/10000
FCM: 1/200 - 1/400
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Liquid
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Buffer
- Ascitic fluid containing 0.03 % sodium azide.
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Konservierungsmittel
- Sodium azide
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Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Lagerung
- 4 °C,-20 °C
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Informationen zur Lagerung
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
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: "IRAK1 and IRAK4 promote phosphorylation, ubiquitination, and degradation of MyD88 adaptor-like (Mal)." in: The Journal of biological chemistry, Vol. 285, Issue 24, pp. 18276-82, (2010) (PubMed).
: "HIV induces both a down-regulation of IRAK-4 that impairs TLR signalling and an up-regulation of the antibiotic peptide dermcidin in monocytic cells." in: Scandinavian journal of immunology, Vol. 70, Issue 3, pp. 264-76, (2009) (PubMed).
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: "IRAK1 and IRAK4 promote phosphorylation, ubiquitination, and degradation of MyD88 adaptor-like (Mal)." in: The Journal of biological chemistry, Vol. 285, Issue 24, pp. 18276-82, (2010) (PubMed).
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- IRAK4 (Interleukin-1 Receptor-Associated Kinase 4 (IRAK4))
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Andere Bezeichnung
- IRAK4
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Hintergrund
- This gene encodes a kinase that activates NF-kappaB in both the Toll-like receptor (TLR) and T-cell receptor (TCR) signaling pathways. The protein is essential for most innate immune responses. Mutations in this gene result in IRAK4 deficiency and recurrent invasive pneumococcal disease. Multiple transcript variants encoding different isoforms have been found for this gene.
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Molekulargewicht
- 52 kDa
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Gen-ID
- 51135
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UniProt
- Q9NWZ3
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Pathways
- NF-kappaB Signalweg, TLR Signalweg, Activation of Innate immune Response, Toll-Like Receptors Cascades
Target
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