RAB8A Antikörper (AA 84-205)

Produktnummer ABIN968210

Der Maus Monoklonal Anti-RAB8A-Antikörper wurde für WB, IHC, IF und IP validiert. Er ist geeignet, RAB8A in Proben von Human, Maus, Ratte, Hund und Blow Fly zu detektieren. Es sind 5+ Publikationen verfügbar.

Kurzübersicht für RAB8A Antikörper (AA 84-205) (ABIN968210)

Target: RAB8A (RAB8A, Member RAS Oncogene Family (RAB8A))

Reaktivität: Human, Maus, Ratte, Hund, Blow Fly

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser RAB8A Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)

Klon: 4-Rab8

Produktdetails anti-RAB8A Antikörper

Bindungsspezifität: AA 84-205

Kreuzreaktivität: Hund, Maus, Ratte (Rattus), Fruchtfliege (Drosophila melanogaster)

Produktmerkmale: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

Aufreinigung: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogen: Human Rab8 aa. 84-205

Isotyp: IgG2b

Anwendungsinformationen

Kommentare:

Related Products: ABIN968537, ABIN967389

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store undiluted at -20° C.

Referenzen für anti-RAB8A Antikörper (ABIN968210)

Bahadoran, Aberdam, Mantoux, Buscà, Bille, Yalman, de Saint-Basile, Casaroli-Marano, Ortonne, Ballotti: "Rab27a: A key to melanosome transport in human melanocytes." in: The Journal of cell biology, Vol. 152, Issue 4, pp. 843-50, (2001) (PubMed).

Hume, Collinson, Rapak, Gomes, Hopkins, Seabra: "Rab27a regulates the peripheral distribution of melanosomes in melanocytes." in: The Journal of cell biology, Vol. 152, Issue 4, pp. 795-808, (2001) (PubMed).

Kessels, Engqvist-Goldstein, Drubin: "Association of mouse actin-binding protein 1 (mAbp1/SH3P7), an Src kinase target, with dynamic regions of the cortical actin cytoskeleton in response to Rac1 activation." in: Molecular biology of the cell, Vol. 11, Issue 1, pp. 393-412, (2000) (PubMed).

Chavrier, Vingron, Sander, Simons, Zerial: "Molecular cloning of YPT1/SEC4-related cDNAs from an epithelial cell line." in: Molecular and cellular biology, Vol. 10, Issue 12, pp. 6578-85, (1991) (PubMed).

Nimmo, Sanders, Padua, Hughes, Williamson, Johnson: "The MEL gene: a new member of the RAB/YPT class of RAS-related genes." in: Oncogene, Vol. 6, Issue 8, pp. 1347-51, (1991) (PubMed).

Details zu RAB8A

Target: RAB8A (RAB8A, Member RAS Oncogene Family (RAB8A))

Andere Bezeichnung: Rab8

Hintergrund: The members of the Ras superfamily of GTPases, which now includes more than 50 different proteins, shuttle between the GDP-bound inactive position and the GTP-bound active state. The GTPase activity of the Ras-like proteins is regulated by effectors that promote either the GDP- or the GTP-bound states. GTPases of the Ras superfamily have a role in controlling numerous events such as cell proliferation, nucleocytoplasmic transport, and vesicular traffic. The Rab superfamily of proteins includes more than 30 different members that are involved in the regulation of different steps of vesicular traffic. Subcellular localization and specific cellular function of each Rab appears to be encoded in the unique C-terminal part of the proteins, known as the hypervariable region. The 207 amino acid Rab8 protein is closely related to the yeast Sec4p and regulates vesicle transport from the Trans-golgi Network to the basolateral plasma membrane in epithelial cells. In addition, Rab8 interacts with the stress-activated kinase rab8p, a close homologue of the GC Kinase. This interaction was found to be dependent on GTP. This antibody is routinely tested by western blot analysis.

Molekulargewicht: 24 kDa

Pathways: M Phase, Regulation of long-term Neuronal Synaptic Plasticity, SARS-CoV-2 Protein Interaktom