RAB8A Antikörper

Produktnummer ABIN4913414

Produktdetails anti-RAB8A Antikörper

Target: RAB8A (RAB8A, Member RAS Oncogene Family (RAB8A))

Reaktivität: Human, Maus

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser RAB8A Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Kreuzreaktivität: Human, Maus

Aufreinigung: Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.

Immunogen: This RAB8A monoclonal antibody is generated from mouse immunized with RAB8A recombinant protein.

Klon: 8A4

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Details zu RAB8A

Target: RAB8A (RAB8A, Member RAS Oncogene Family (RAB8A))

Andere Bezeichnung: RAB8A (RAB8A Produkte)

Hintergrund:

Synonyms: MEL, RAB8, Ras-related protein Rab-8A, Oncogene c-mel, RAB8A

Background: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in polarized vesicular trafficking and neurotransmitter release. Together with RAB11A, RAB3IP, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis. Together with MYO5B and RAB11A participates in epithelial cell polarization. Plays an important role in ciliogenesis. Together with MICALL2, may also regulate adherens junction assembly. May play a role in insulin-induced transport to the plasma membrane of the glucose transporter GLUT4 and therefore play a role in glucose homeostasis.

Gen-ID: 4218

UniProt: P61006

Pathways: M Phase, Regulation of long-term Neuronal Synaptic Plasticity, SARS-CoV-2 Protein Interaktom