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Cyclin D3 Antikörper (AA 127-292)

Dieses Maus Monoklonal-Antikörper erkennt spezifisch Cyclin D3 in WB, IHC, IP und IF. Er zeigt eine Reaktivität gegenüber Human, Maus, Ratte und Hund und wurde in 5+ Publikationen erwähnt.
Produktnummer ABIN967879

Kurzübersicht für Cyclin D3 Antikörper (AA 127-292) (ABIN967879)

Target

Alle Cyclin D3 (CCND3) Antikörper anzeigen
Cyclin D3 (CCND3)

Reaktivität

  • 101
  • 32
  • 21
  • 16
  • 6
  • 4
  • 4
  • 3
  • 2
  • 1
  • 1
  • 1
  • 1
Human, Maus, Ratte, Hund

Wirt

  • 88
  • 15
Maus

Klonalität

  • 80
  • 23
Monoklonal

Konjugat

  • 51
  • 5
  • 4
  • 4
  • 3
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
Dieser Cyclin D3 Antikörper ist unkonjugiert

Applikation

  • 74
  • 34
  • 27
  • 26
  • 23
  • 21
  • 15
  • 14
  • 9
  • 7
  • 6
  • 4
  • 1
  • 1
  • 1
  • 1
Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunofluorescence (IF)

Klon

1-Cyclin D3
  • Bindungsspezifität

    • 24
    • 16
    • 7
    • 7
    • 6
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 127-292

    Kreuzreaktivität

    Maus, Ratte (Rattus), Hund

    Produktmerkmale

    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

    Aufreinigung

    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

    Immunogen

    Human Cyclin D3 aa. 127-292

    Isotyp

    IgG2b
  • Kommentare

    Related Products: ABIN967389

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    250 μg/mL

    Buffer

    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    Store undiluted at -20° C.
  • Haller, Wu, Derow, Schmitt, Jeang, Grassmann: "Physical interaction of human T-cell leukemia virus type 1 Tax with cyclin-dependent kinase 4 stimulates the phosphorylation of retinoblastoma protein." in: Molecular and cellular biology, Vol. 22, Issue 10, pp. 3327-38, (2002) (PubMed).

    Saitoh, Pizzi, Wang: "Perturbation of SUMOlation enzyme Ubc9 by distinct domain within nucleoporin RanBP2/Nup358." in: The Journal of biological chemistry, Vol. 277, Issue 7, pp. 4755-63, (2002) (PubMed).

    Bagui, Jackson, Agrawal, Pledger: "Analysis of cyclin D3-cdk4 complexes in fibroblasts expressing and lacking p27(kip1) and p21(cip1)." in: Molecular and cellular biology, Vol. 20, Issue 23, pp. 8748-57, (2000) (PubMed).

    Motokura, Keyomarsi, Kronenberg, Arnold: "Cloning and characterization of human cyclin D3, a cDNA closely related in sequence to the PRAD1/cyclin D1 proto-oncogene." in: The Journal of biological chemistry, Vol. 267, Issue 28, pp. 20412-5, (1992) (PubMed).

    Xiong, Menninger, Beach, Ward: "Molecular cloning and chromosomal mapping of CCND genes encoding human D-type cyclins." in: Genomics, Vol. 13, Issue 3, pp. 575-84, (1992) (PubMed).

  • Target

    Cyclin D3 (CCND3)

    Andere Bezeichnung

    Cyclin D3

    Hintergrund

    Several classes of cyclins (A-E) have been described. These proteins act as regulatory subunits for cyclin-dependent kinases (cdks). The synthesis and degradation of cyclins is tightly controlled in a cell cycle specific manner. There are at least 3 different D-type cyclins whose relative levels vary among cell types. Cyclin D3 is known to associate with Cdk5 and weakly with Cdk2. Cdk4 is preferentially bound by Cyclin D1. However, in T cells which do not express Cyclin D1, Cdk4 associates with Cyclins D2 and D3. While bound to cdks, the D-type cyclins also associate with the polymerase-delta subunit, PCNA. Cyclin D3 has also been shown to bind pRb in vitro. This suggests that pRb may be an in vivo substrate of D-type cyclins. This antibody is routinely tested by western blot analysis.

    Molekulargewicht

    33 kDa

    Pathways

    Zellzyklus, Mitotic G1-G1/S Phases, Glycosaminoglycan Metabolic Process
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