PCNA Antikörper (Proliferating Cell Nuclear Antigen)

Details for Product anti-PCNA Antibody No. ABIN966811, Anbieter: Anmelden zum Anzeigen
Antigen
  • PCNAR
  • Pcna/cyclin
  • pcna
  • AO090003000846
  • 53/13
  • CG9193
  • DmPCNA
  • Dmel\\CG9193
  • MUS209
  • Mus209
  • PCNA
  • PCNA/mus209
  • Pcna
  • dPCNA
  • l(2)02448
  • l(2)56F
  • l(2)56Fa
  • l(2)s1534
  • cb16
  • fb36g03
  • wu:fa28e03
  • wu:fb36g03
  • pcna-A
  • proliferating cell nuclear antigen
  • DNA polymerase III sliding clamp
  • Proliferating cell nuclear antigen
  • Proliferating cell nuclear antigen-like
  • proliferating cell nuclear antigen L homeolog
  • proliferating cell nuclear antigen 1
  • PCNA
  • Pcna
  • pcna
  • MMP_RS08810
  • ANI_1_512014
  • AOR_1_1500154
  • MGC53867
  • pcna.L
  • pcna1
  • LOC106420145
  • pcn1
Reaktivität
Human, Ratte (Rattus)
704
342
334
95
95
93
76
75
66
60
40
32
32
29
26
26
13
11
7
7
6
6
5
4
3
3
3
3
3
3
2
2
2
1
1
1
1
Wirt
Kaninchen
450
284
19
3
Klonalität
Polyklonal
Konjugat
Dieser PCNA Antikörper ist unkonjugiert
34
29
21
14
14
13
9
8
8
8
8
8
8
8
8
8
8
6
6
6
5
5
5
5
5
5
5
5
5
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
Applikation
Immunohistochemistry (IHC)
587
266
250
213
200
184
100
99
67
57
45
13
13
7
7
4
3
2
2
1
1
1
1
1
1
1
1
Optionen
Hersteller
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Hersteller Produkt- Nr.
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Immunogen Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to C-residues of human PCNA (proliferating cell nuclear antigen)
Plasmids, Primers & others Plasmide, Primers & weitere PCNA products on genomics-online (e.g. as negative or positive controls)
Antigen
Andere Bezeichnung PCNA (PCNA Antibody Abstract)
Hintergrund The protein encoded by this gene is found in the nucleus and is a cofactor of DNA polymerase delta. The encoded protein acts as a homotrimer and helps increase the processivity of leading strand synthesis during DNA replication. In response to DNA damage, this protein is ubiquitinated and is involved in the RAD6-dependent DNA repair pathway. Two transcript variants encoding the same protein have been found for this gene. Pseudo genes of this gene have been described on chromosome 4 and on the X chromosome.
Pathways Telomere Maintenance, DNA Reparatur, Mitotic G1-G1/S Phases, DNA Replication, Synthesis of DNA, Autophagie
Beschränkungen Nur für Forschungszwecke einsetzbar
Produkt verwendet in: Kweekel, Antonini, Nortier, Punt, Gelderblom, Guchelaar: "Explorative study to identify novel candidate genes related to oxaliplatin efficacy and toxicity using a DNA repair array." in: British journal of cancer, Vol. 101, Issue 2, pp. 357-62, 2009 (PubMed).

Niwa, Miwa, Kuzuya, Iwasaki, Haneda, Ueki, Katayama, Hiramitsu, Goto, Nagasaka, Watarai, Uchida, Nakao, Kobayashi: "Stimulation index for PCNA mRNA in peripheral blood as immune function monitoring after renal transplantation." in: Transplantation, Vol. 87, Issue 9, pp. 1411-4, 2009 (PubMed).

Michiels, Laplanche, Boulet, Dessen, Guillonneau, Méjean, Desgrandchamps, Lathrop, Sarasin, Benhamou: "Genetic polymorphisms in 85 DNA repair genes and bladder cancer risk." in: Carcinogenesis, Vol. 30, Issue 5, pp. 763-8, 2009 (PubMed).

Canova, Hashibe, Simonato, Nelis, Metspalu, Lagiou, Trichopoulos, Ahrens, Pigeot, Merletti, Richiardi, Talamini, Barzan, Macfarlane, Macfarlane, Holcátová, Bencko, Benhamou, Bouchardy, Kjaerheim et al.: "Genetic associations of 115 polymorphisms with cancers of the upper aerodigestive tract across 10 European countries: the ARCAGE project. ..." in: Cancer research, Vol. 69, Issue 7, pp. 2956-65, 2009 (PubMed).

Chen, Pan, Hurwitz: "Sequence and expression in Escherichia coli of the 40-kDa subunit of activator 1 (replication factor C) of HeLa cells." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 89, Issue 7, pp. 2516-20, 1992 (PubMed).

Webb, Parsons, Chenevix-Trench: "Localization of the gene for human proliferating nuclear antigen/cyclin by in situ hybridization." in: Human genetics, Vol. 86, Issue 1, pp. 84-6, 1991 (PubMed).

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