MDM2
(Mdm2, p53 E3 Ubiquitin Protein Ligase Homolog (Mouse) (MDM2))
Bindungsspezifität
AA 103-119, N-Term
Reaktivität
Human, Ratte
Wirt
Bitte anfragen
Klonalität
Polyklonal
Konjugat
Dieser MDM2 Antikörper ist unkonjugiert
Applikation
Western Blotting (WB)
Immunogen
A synthetic peptide corresponding to a sequence at the N-terminal of human MDM2 (103-119 aa), different from the mouse sequence by three amino acids, and rat sequence by two amino acids.
Mdm2 is an important negative regulator of the p53 tumor suppressor. It is the name of a gene as well as the protein encoded by that gene. Mdm2 protein functions both as an E3 ubiquity lipase that recognizes the N-terminal trans-activation domain (TAD) of the p53 tumor suppressor and an inhibitor of p53 transcriptional activation. Oliner et al. (1992) used MDM2 clones to localize the human gene to chromosome 12q13-q14 by analysis of human-hamster somatic cell hybrids.