(1 reference)-
- Target Alle MDM2 Antikörper anzeigen
- MDM2 (Mdm2, p53 E3 Ubiquitin Protein Ligase Homolog (Mouse) (MDM2))
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Bindungsspezifität
- AA 103-119, N-Term
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Reaktivität
- Human, Ratte
- Wirt
- Bitte anfragen
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Klonalität
- Polyklonal
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Konjugat
- Dieser MDM2 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB)
- Immunogen
- A synthetic peptide corresponding to a sequence at the N-terminal of human MDM2 (103-119 aa), different from the mouse sequence by three amino acids, and rat sequence by two amino acids.
- Top Product
- Discover our top product MDM2 Primärantikörper
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anti-Mdm2, p53 E3 Ubiquitin Protein Ligase Homolog (Mouse) (MDM2) (AA 101-200) antibody
MDM2 Reaktivität: Human WB, ELISA, IHC (p), RNAi, PLA Wirt: Maus Monoclonal 1A7 unconjugated
anti-Mdm2, p53 E3 Ubiquitin Protein Ligase Homolog (Mouse) (MDM2) (Center) antibodyMDM2 Reaktivität: Human, Maus WB, IF, IHC (p), IP, ICC, ChIP Wirt: Kaninchen Polyclonal unconjugated
anti-Mdm2, p53 E3 Ubiquitin Protein Ligase Homolog (Mouse) (MDM2) (AA 130-230) antibodyMDM2 Reaktivität: Human WB, IHC, IF Wirt: Kaninchen Polyclonal unconjugated
anti-Mdm2, p53 E3 Ubiquitin Protein Ligase Homolog (Mouse) (MDM2) (AA 141-176) antibodyMDM2 Reaktivität: Human WB, IF, IHC (p), FACS Wirt: Kaninchen Polyclonal RB7981 unconjugated
anti-Mdm2, p53 E3 Ubiquitin Protein Ligase Homolog (Mouse) (MDM2) (AA 26-169) antibodyMDM2 Reaktivität: Human ELISA, IHC, FACS Wirt: Maus Monoclonal 3C1E3 unconjugated
anti-Mdm2, p53 E3 Ubiquitin Protein Ligase Homolog (Mouse) (MDM2) (pSer166) antibodyMDM2 Reaktivität: Human, Maus, Affe WB, ELISA, IHC, IF, ICC Wirt: Kaninchen Polyclonal unconjugated
anti-Mdm2, p53 E3 Ubiquitin Protein Ligase Homolog (Mouse) (MDM2) (AA 393-424) antibodyMDM2 Reaktivität: Human, Maus WB, ELISA, IHC Wirt: Kaninchen Polyclonal unconjugated
anti-Mdm2, p53 E3 Ubiquitin Protein Ligase Homolog (Mouse) (MDM2) (pSer186) antibodyMDM2 Reaktivität: Human WB, ELISA, IHC (p), IF (cc), IF (p), ICC, IHC (fro) Wirt: Kaninchen Polyclonal unconjugated
anti-Mdm2, p53 E3 Ubiquitin Protein Ligase Homolog (Mouse) (MDM2) (AA 26-169) antibodyMDM2 Reaktivität: Human ELISA, FACS Wirt: Maus Monoclonal 4A8D12 unconjugated
anti-Mdm2, p53 E3 Ubiquitin Protein Ligase Homolog (Mouse) (MDM2) antibodyMDM2 Reaktivität: Human, Maus, Ratte, Affe WB, ELISA, IHC, IF, IP, ICC Wirt: Kaninchen Polyclonal unconjugated
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- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Rekonstitution
- 0.2ml of distilled water will yield a concentration of 500µg/ml.
- Buffer
- Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4
- Konservierungsmittel
- Thimerosal (Merthiolate), Sodium azide
- Lagerung
- -20 °C
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: "Structure of free MDM2 N-terminal domain reveals conformational adjustments that accompany p53-binding." in: Journal of molecular biology, Vol. 350, Issue 3, pp. 587-98, (2005) (PubMed).
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: "Structure of free MDM2 N-terminal domain reveals conformational adjustments that accompany p53-binding." in: Journal of molecular biology, Vol. 350, Issue 3, pp. 587-98, (2005) (PubMed).
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- Target
- MDM2 (Mdm2, p53 E3 Ubiquitin Protein Ligase Homolog (Mouse) (MDM2))
- Andere Bezeichnung
- MDM2 (MDM2 Produkte)
- Hintergrund
- Mdm2 is an important negative regulator of the p53 tumor suppressor. It is the name of a gene as well as the protein encoded by that gene. Mdm2 protein functions both as an E3 ubiquity lipase that recognizes the N-terminal trans-activation domain (TAD) of the p53 tumor suppressor and an inhibitor of p53 transcriptional activation. Oliner et al. (1992) used MDM2 clones to localize the human gene to chromosome 12q13-q14 by analysis of human-hamster somatic cell hybrids.
- Pathways
- p53 Signalweg, PI3K-Akt Signalweg, Zellzyklus, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Autophagie, Ubiquitin Proteasome Pathway
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