LYN Antikörper

Produktnummer ABIN966504

Zitiert in 2+ Publikationen. Der Monoklonal anti-LYN Antikörper (Klon 2H8D7) (ABIN966504) detektiert spezifisch LYN in ELISA. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für LYN Antikörper (ABIN966504)

Target: LYN (V-Yes-1 Yamaguchi Sarcoma Viral Related Oncogene Homolog (LYN))

Reaktivität: Human

Wirt: Bitte anfragen

Klonalität: Monoklonal

Konjugat: Dieser LYN Antikörper ist unkonjugiert

Applikation: ELISA

Klon: 2H8D7

Produktdetails anti-LYN Antikörper

Spezifität: Ni-NTA purified truncated recombinant Lyn expressed in E. Coli strain BL21 (DE3).

Aufreinigung: Antibodies are purified by protein A affinity chromatography

Immunogen: Ni-NTA purified truncated recombinant Lyn expressed in E.coli strain BL21 (DE3)

Isotyp: IgG2b

Anwendungsinformationen

Applikationshinweise: ELISA: Propose dilution 1: 10,000.
Determining optimal working dilutions by titration test.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Lagerung: -20 °C

Referenzen für anti-LYN Antikörper (ABIN966504)

Williams, Wierenga, Saraste: "Insights into Src kinase functions: structural comparisons." in: Trends in biochemical sciences, Vol. 23, Issue 5, pp. 179-84, (1998) (PubMed).

Hibbs, Dunn: "Lyn, a src-like tyrosine kinase." in: The international journal of biochemistry & cell biology, Vol. 29, Issue 3, pp. 397-400, (1997) (PubMed).

Details zu LYN

Target: LYN (V-Yes-1 Yamaguchi Sarcoma Viral Related Oncogene Homolog (LYN))

Andere Bezeichnung: LYN

Hintergrund: Lyn (also known as p53/56 Lyn) is a membrane-associated protein tyrosine kinase (PTK) mostly expressed in hemopoietic cells which is important in cellular signaling. It contains an SH2 and SH3 domain and has been found to be cleaved after activation of caspases in apoptosis. A member of the Src family of PTKs, there are two known isoforms for Lyn which plays an indispensable role in the Fc epsilon RI (Fcer1) and the B-cell IgM receptor signaling pathway and is essential for Syk activation and Lat phosphorylation after Fcer1 aggregation and can also phosphor-ylate Tec on multiple residues. Lyn can also be regulated by IL-2 and IL-3.Lyn is a member of the src family of non-receptor protein tyrosine kinases that is predominantly expressed in haematopoietic tissues. Like all members of the src family, lyn is thought to participate in signal transduction from cell surface receptors that lack intrinsic tyrosine kinase activity. It is associated with a number of cell surface receptors including the B cell antigen receptor and immunoglobulin E receptor (FceRI).

Gen-ID: 4067

Pathways: Fc-epsilon Rezeptor Signalübertragung, Hormone Transport, Response to Growth Hormone Stimulus, Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, CXCR4-mediated Signaling Events, Thromboxane A2 Receptor Signaling, Integrin Complex, BCR Signaling