LYN Antikörper (pTyr508)

Produktnummer ABIN743603

Der Kaninchen Polyklonal anti-LYN Antikörper wird verwendet zum Nachweis von LYN in Proben von Human. Er wurde validiert für WB, IHC (p) und IF (p).

Kurzübersicht für LYN Antikörper (pTyr508) (ABIN743603)

Target: LYN (V-Yes-1 Yamaguchi Sarcoma Viral Related Oncogene Homolog (LYN))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser LYN Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Produktdetails anti-LYN Antikörper

Bindungsspezifität: pTyr508

Verwendungszweck: Phospho-Lyn (Tyr507) Polyclonal Antibody

Kreuzreaktivität: Human, Maus, Ratte

Homologie: Dog,Cow,Sheep,Pig,Horse,Chicken,Cat,Rabbit,Zebrafish,GuineaPig

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic phosphopeptide derived from human Lyn around the phosphorylation site of Tyr508

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB(1:300-5000), IHC-P(1:200-400), IF(IHC-P)(1:50-200)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C for 12 months.

Haltbarkeit: 12 months

Details zu LYN

Target: LYN (V-Yes-1 Yamaguchi Sarcoma Viral Related Oncogene Homolog (LYN))

Andere Bezeichnung: Lyn

Hintergrund:

Synonyms: Lyn phospho Y508, Lyn phospho Tyr508, p-Lyn Tyr508, Hck 2, JTK 8, JTK8, ONCOGENE LYN, Tyrosine protein kinase LYN, V yes 1 Yamaguchi sarcoma viral related oncogene homolog, Yamaguchi sarcoma viral v yes 1 related oncogene homolog, AA407514, EC 2.7.10.2, FLJ26625, LYN_HUMAN.

Background: Lyn (also known as p53/56 Lyn) is a membrane associated protein tyrosine kinase (PTK) mostly expressed in hemopoietic cells which is important in cellular signaling. It contains an SH2 and SH3 domain and has been found to be cleaved after activation of caspases in apoptosis. A member of the Src family of PTKs, there are two known isoforms for Lyn which plays an indispensable role in the Fc epsilon RI (Fcer1) and the B cell IgM receptor signaling pathway and is essential for Syk activation and Lat phosphorylation after Fcer1 aggregation and can also phosphorylate Tec on multiple residues. Lyn can also be regulated by IL2 and IL3.

Molekulargewicht: 57kDa

Gen-ID: 4067

Pathways: Fc-epsilon Rezeptor Signalübertragung, Hormone Transport, Response to Growth Hormone Stimulus, Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, CXCR4-mediated Signaling Events, Thromboxane A2 Receptor Signaling, Integrin Complex, BCR Signaling