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LYN Antikörper (AA 1-210)

LYN Reaktivität: Human WB Wirt: Maus Monoclonal 1174CT22-3-1-1 unconjugated
Produktnummer ABIN1944840
  • Target Alle LYN Antikörper anzeigen
    LYN (V-Yes-1 Yamaguchi Sarcoma Viral Related Oncogene Homolog (LYN))
    Bindungsspezifität
    • 22
    • 19
    • 16
    • 13
    • 9
    • 9
    • 7
    • 5
    • 5
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1-210
    Reaktivität
    • 137
    • 100
    • 75
    • 21
    • 17
    • 15
    • 15
    • 15
    • 8
    • 4
    • 3
    • 2
    • 2
    • 1
    Human
    Wirt
    • 135
    • 13
    • 1
    • 1
    Maus
    Klonalität
    • 131
    • 20
    Monoklonal
    Konjugat
    • 80
    • 11
    • 11
    • 7
    • 6
    • 5
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    Dieser LYN Antikörper ist unkonjugiert
    Applikation
    • 126
    • 63
    • 47
    • 25
    • 25
    • 22
    • 18
    • 14
    • 8
    • 8
    • 4
    • 3
    • 2
    • 1
    Western Blotting (WB)
    Aufreinigung
    This antibody is purified through a protein G column, followed by dialysis against PBS.
    Immunogen
    This antibody is generated from a mouse immunized with a KLH conjugated synthetic peptide between 1-210 amino acids from human.
    Klon
    1174CT22-3-1-1
    Isotyp
    IgG1 kappa
    Top Product
    Discover our top product LYN Primärantikörper
  • Applikationshinweise
    WB: 1:1000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Haltbarkeit
    6 months
  • Rider, Raben, Miller, Jelsema: "The cDNAs encoding two forms of the LYN protein tyrosine kinase are expressed in rat mast cells and human myeloid cells." in: Gene, Vol. 138, Issue 1-2, pp. 219-22, (1994) (PubMed).

    Roifman, Ke: "CD19 is a substrate of the antigen receptor-associated protein tyrosine kinase in human B cells." in: Biochemical and biophysical research communications, Vol. 194, Issue 1, pp. 222-5, (1993) (PubMed).

    Bielke, Ziemieki, Kappos, Miescher: "Expression of the B cell-associated tyrosine kinase gene Lyn in primary neuroblastoma tumours and its modulation during the differentiation of neuroblastoma cell lines." in: Biochemical and biophysical research communications, Vol. 186, Issue 3, pp. 1403-9, (1992) (PubMed).

    Partanen, Mäkelä, Alitalo, Lehväslaiho, Alitalo: "Putative tyrosine kinases expressed in K-562 human leukemia cells." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 87, Issue 22, pp. 8913-7, (1991) (PubMed).

  • Target
    LYN (V-Yes-1 Yamaguchi Sarcoma Viral Related Oncogene Homolog (LYN))
    Andere Bezeichnung
    LYN (LYN Produkte)
    Synonyme
    JTK8 antikoerper, p53Lyn antikoerper, p56Lyn antikoerper, lyn antikoerper, LYN antikoerper, AA407514 antikoerper, Hck-2 antikoerper, jtk8 antikoerper, lyn-A antikoerper, CH73-38P6.3 antikoerper, zgc:92124 antikoerper, LYN proto-oncogene, Src family tyrosine kinase antikoerper, v-yes-1 Yamaguchi sarcoma viral related oncogene homolog antikoerper, tyrosine-protein kinase Lyn antikoerper, LYN proto-oncogene, Src family tyrosine kinase L homeolog antikoerper, LYN antikoerper, lyn antikoerper, Lyn antikoerper, LOC100593961 antikoerper, lyn.L antikoerper
    Hintergrund
    Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors and plays an important role in the regulation of innate and adaptive immune responses, hematopoiesis, responses to growth factors and cytokines, integrin signaling, but also responses to DNA damage and genotoxic agents. Functions primarily as negative regulator, but can also function as activator, depending on the context. Required for the initiation of the B-cell response, but also for its down- regulation and termination. Plays an important role in the regulation of B-cell differentiation, proliferation, survival and apoptosis, and is important for immune self-tolerance. Acts downstream of several immune receptors, including the B-cell receptor, CD79A, CD79B, CD5, CD19, CD22, FCER1, FCGR2, FCGR1A, TLR2 and TLR4. Plays a role in the inflammatory response to bacterial lipopolysaccharide. Mediates the responses to cytokines and growth factors in hematopoietic progenitors, platelets, erythrocytes, and in mature myeloid cells, such as dendritic cells, neutrophils and eosinophils. Acts downstream of EPOR, KIT, MPL, the chemokine receptor CXCR4, as well as the receptors for IL3, IL5 and CSF2. Plays an important role in integrin signaling. Regulates cell proliferation, survival, differentiation, migration, adhesion, degranulation, and cytokine release. Down- regulates signaling pathways by phosphorylation of immunoreceptor tyrosine-based inhibitory motifs (ITIM), that then serve as binding sites for phosphatases, such as PTPN6/SHP-1, PTPN11/SHP-2 and INPP5D/SHIP-1, that modulate signaling by dephosphorylation of kinases and their substrates. Phosphorylates LIME1 in response to CD22 activation. Phosphorylates BTK, CBL, CD5, CD19, CD72, CD79A, CD79B, CSF2RB, DOK1, HCLS1, LILRB3/PIR-B, MS4A2/FCER1B, PTK2B/PYK2, SYK and TEC. Promotes phosphorylation of SIRPA, PTPN6/SHP-1, PTPN11/SHP-2 and INPP5D/SHIP-1. Mediates phosphorylation of the BCR-ABL fusion protein. Required for rapid phosphorylation of FER in response to FCER1 activation. Mediates KIT phosphorylation. Acts as an effector of EPOR (erythropoietin receptor) in controlling KIT expression and may play a role in erythroid differentiation during the switch between proliferation and maturation. Depending on the context, activates or inhibits several signaling cascades. Regulates phosphatidylinositol 3- kinase activity and AKT1 activation. Regulates activation of the MAP kinase signaling cascade, including activation of MAP2K1/MEK1, MAPK1/ERK2, MAPK3/ERK1, MAPK8/JNK1 and MAPK9/JNK2. Mediates activation of STAT5A and/or STAT5B. Phosphorylates LPXN on 'Tyr- 72'.
    Molekulargewicht
    58574
    Gen-ID
    4067
    UniProt
    P07948
    Pathways
    Fc-epsilon Rezeptor Signalübertragung, Hormone Transport, Response to Growth Hormone Stimulus, Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, CXCR4-mediated Signaling Events, Thromboxane A2 Receptor Signaling, Integrin Complex, BCR Signaling
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