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LYN Antikörper (AA 8-238)

LYN Reaktivität: Human, Maus, Ratte WB, IP, ICC Wirt: Maus Monoclonal LYN-01 unconjugated
Produktnummer ABIN94427
  • Target Alle LYN Antikörper anzeigen
    LYN (V-Yes-1 Yamaguchi Sarcoma Viral Related Oncogene Homolog (LYN))
    Bindungsspezifität
    • 22
    • 19
    • 16
    • 13
    • 9
    • 9
    • 7
    • 5
    • 5
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 8-238
    Reaktivität
    • 137
    • 99
    • 74
    • 21
    • 17
    • 15
    • 15
    • 15
    • 8
    • 4
    • 3
    • 2
    • 2
    • 1
    Human, Maus, Ratte
    Wirt
    • 135
    • 13
    • 1
    • 1
    Maus
    Klonalität
    • 131
    • 20
    Monoklonal
    Konjugat
    • 80
    • 11
    • 11
    • 7
    • 6
    • 5
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    Dieser LYN Antikörper ist unkonjugiert
    Applikation
    • 126
    • 63
    • 47
    • 25
    • 25
    • 22
    • 17
    • 14
    • 8
    • 7
    • 4
    • 3
    • 2
    • 1
    Western Blotting (WB), Immunoprecipitation (IP), Immunocytochemistry (ICC)
    Spezifität
    The antibody LYN-01 reacts with Lyn (p56/p53), a non-receptor Src-family tyrosine kinase expressed in hematopoietic tissues (intracellular antigen).
    Kreuzreaktivität (Details)
    Mouse, Human, Rat
    Aufreinigung
    Purified by protein-A affinity chromatography.
    Reinheit
    > 95 % (by SDS-PAGE)
    Immunogen
    Bacterially expressed recombinant fragment of human Lyn (aa 8 - 238).
    Klon
    LYN-01
    Isotyp
    IgG1
    Top Product
    Discover our top product LYN Primärantikörper
  • Applikationshinweise
    Western blotting: Recommended dilution: 1-2 μg/mL.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    1 mg/mL
    Buffer
    Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Do not freeze.
    Lagerung
    4 °C
    Informationen zur Lagerung
    Store at 2-8°C. Do not freeze.
  • Queval, Nicolas, Beau: "Role of Src kinases in mobilization of glycosylphosphatidylinositol-anchored decay-accelerating factor by Dr fimbria-positive adhering bacteria." in: Infection and immunity, Vol. 79, Issue 7, pp. 2519-34, (2011) (PubMed).

    Amoui, Dráberová, Tolar, Dráber: "Direct interaction of Syk and Lyn protein tyrosine kinases in rat basophilic leukemia cells activated via type I Fc epsilon receptors." in: European journal of immunology, Vol. 27, Issue 1, pp. 321-8, (1997) (PubMed).

    Dráberová, Amoui, Dráber: "Thy-1-mediated activation of rat mast cells: the role of Thy-1 membrane microdomains." in: Immunology, Vol. 87, Issue 1, pp. 141-8, (1996) (PubMed).

  • Target
    LYN (V-Yes-1 Yamaguchi Sarcoma Viral Related Oncogene Homolog (LYN))
    Andere Bezeichnung
    Lyn (LYN Produkte)
    Synonyme
    JTK8 antikoerper, p53Lyn antikoerper, p56Lyn antikoerper, lyn antikoerper, LYN antikoerper, AA407514 antikoerper, Hck-2 antikoerper, jtk8 antikoerper, lyn-A antikoerper, CH73-38P6.3 antikoerper, zgc:92124 antikoerper, LYN proto-oncogene, Src family tyrosine kinase antikoerper, v-yes-1 Yamaguchi sarcoma viral related oncogene homolog antikoerper, tyrosine-protein kinase Lyn antikoerper, LYN proto-oncogene, Src family tyrosine kinase L homeolog antikoerper, LYN antikoerper, lyn antikoerper, Lyn antikoerper, LOC100593961 antikoerper, lyn.L antikoerper
    Hintergrund
    LYN proto-oncogene, Src family tyrosine kinase,Lyn is a Src-family protein tyrosine kinase that is predominantly expressed in hematopoietic cells. It is associated with a number of cell surface receptors including the B cell antigen receptor (BCR) and Fc receptors. Upon their triggering, Lyn phosphorylates subunits of these receptors in a cholesterol-dependent manner, utilizing the plasma membrane lipid raft system. The phosphorylated intracellular domains of the receptors are accessible for cytoplasmic Syk tyrosine kinase, which is activated by Lyn-mediated phosphorylation and which transduces the signal to downstream adaptors. Lyn is abnormally distributed in acute myeloid leukemia cells and seems to be a novel pharmacologic target of this disease.,JTK8, p56Lyn, p53Lyn
    Gen-ID
    4067
    UniProt
    P07948
    Pathways
    Fc-epsilon Rezeptor Signalübertragung, Hormone Transport, Response to Growth Hormone Stimulus, Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, CXCR4-mediated Signaling Events, Thromboxane A2 Receptor Signaling, Integrin Complex, BCR Signaling
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