CHEK1 Antikörper
Kurzübersicht für CHEK1 Antikörper (ABIN965882)
Target
Alle CHEK1 Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
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Spezifität
- Ni-NTA purified recombinant protein CHK1 expressed in E. Coli strain M15.
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Aufreinigung
- Antibodies are purified by protein G affinity chromatography.
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Isotyp
- IgG1
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Applikationshinweise
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Western Blot: Dilution 1: 2,00- 1: 1,000
ELISA: Propose dilution 1: 10,000.
Determining optimal working dilutions by titration test. -
Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Lagerung
- -20 °C
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: "Chk1 is a wee1 kinase in the G2 DNA damage checkpoint inhibiting cdc2 by Y15 phosphorylation." in: The EMBO journal, Vol. 16, Issue 3, pp. 545-54, (1997) (PubMed).
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: "Chk1 is a wee1 kinase in the G2 DNA damage checkpoint inhibiting cdc2 by Y15 phosphorylation." in: The EMBO journal, Vol. 16, Issue 3, pp. 545-54, (1997) (PubMed).
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- CHEK1 (Checkpoint Kinase 1 (CHEK1))
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Andere Bezeichnung
- CHK1
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Hintergrund
- Active recombinant full length human CHK1 containing an Nterminal GST tag. This protein has an apparent molecular weight of ~82kDa. CHK1 appears to function downstream of several of the known fission yeast checkpoint gene products, including that encoded by rad3+, a gene with sequence similarity to the ATM gene mutated in patients with ataxia telangiectasia.
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Pathways
- p53 Signalweg, Apoptose, Zellzyklus, DNA Reparatur
Target
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