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CHEK1 Antikörper (C-Term)

CHEK1 Reaktivität: Human IHC Wirt: Kaninchen Polyclonal unconjugated

Produktnummer ABIN965880

Datenblatt (PDF)

Target Alle CHEK1 Antikörper anzeigen

CHEK1 (Checkpoint Kinase 1 (CHEK1))
Bindungsspezifität
36

27

19

15

9

7

6

6

5

3

2

2

2

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
C-Term
Reaktivität
170

111

61

16

11

8

6

6

6

4

4

3

2

1

1
Human
Wirt
183

12

5

5
Kaninchen
Passende Sekundärantikörper
Klonalität
184

22
Polyklonal
Konjugat
112

11

9

8

4

4

4

4

4

4

4

4

4

3

3

3

3

3

3

3

3

3

3
Dieser CHEK1 Antikörper ist unkonjugiert
Applikation
155

80

48

41

40

33

28

15

10

10

7

6

3

3

2

1

1
Immunohistochemistry (IHC)

Aufreinigung

Purified by antigen-specific affinity chromatography.

Immunogen

Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to C-terminal residues of human CHEK1(Serine/threonine-protein kinase Chk1)

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CHEK1 Reaktivität: Human WB, ELISA, IHC, IF Wirt: Kaninchen Monoclonal 2F2 unconjugated Recombinant Antibody

anti-Checkpoint Kinase 1 (CHEK1) antibody
CHEK1 Reaktivität: Human, Maus WB, ELISA Wirt: Maus Monoclonal 2G1D5 unconjugated

Applikationshinweise

ELISA, Western blotting: 1µg/ml for 2hrs.

Beschränkungen

Nur für Forschungszwecke einsetzbar
Format

Liquid

Buffer

This antibody is stored in PBS, 50% glycerol

Konservierungsmittel

Sodium azide

Vorsichtsmaßnahmen

This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung

-20 °C
Target

CHEK1 (Checkpoint Kinase 1 (CHEK1))

Andere Bezeichnung

CHEK1 (CHEK1 Produkte)

Hintergrund

CHEK1(Serine/threonine-protein kinase Chk1) involved in cell cycle arrest when dna damage has occurred or when unligated dna is present. CHEK1 binds to and phosphorylates CDC25A, CDC25B and CDC25C. The phosphorylation of CDC25C creates a binding site for 14-3-3 protein which inhibits CDC25C. This prevents activation of the CDC2-Cyclin B complex and prevents mitotic entry. The CHEK1 phosphorylates CDC25C on serine216. Chk1 plays a primary role in the protection of cells from death induced by replication fork stress, whereas p21 mediates through its role in regulating entry into S phase. Chk1 deficiency resulted in a premature onset of mitosis because of abnormal activation of cyclin B-Cdc2 and led to the activation of caspases 3 and 9 triggered by cytoplasmic release of cytochrome c. It belongs to the Ser/Thr family of protein kinases and NIM1 subfamily.

Pathways

p53 Signalweg, Apoptose, Zellzyklus, DNA Reparatur