Prothrombin Antikörper

Produktnummer ABIN954323

Der Maus Monoklonal Anti-Prothrombin-Antikörper wurde für WB und EIA validiert. Er ist geeignet, Prothrombin in Proben von Human zu detektieren.

Kurzübersicht für Prothrombin Antikörper (ABIN954323)

Target: Prothrombin (F2) (Coagulation Factor II (thrombin) (F2))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Prothrombin Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA)

Klon: CaPro-20

Produktdetails anti-Prothrombin Antikörper

Spezifität: This antibody is specific for Human Prothrombin (CaPro-20).

Kreuzreaktivität (Details): Species reactivity (tested):Human.

Aufreinigung: Protein G Chromatography of Ascitic fluid.

Immunogen: Human Prothrombin (CaPro-20) purified from plasma.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % Sodium Azide as preservative.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu Prothrombin

Target: Prothrombin (F2) (Coagulation Factor II (thrombin) (F2))

Andere Bezeichnung: Prothrombin (F2)

Hintergrund: Prothrombin (Factor 2 in the coagulation cascade) is proteolytically cleaved at two sites by Factor Xa to form thrombin (Factor IIa) in an important step of the coagulation cascade which ultimately results in the stemming of blood loss. Thrombin being the single most important constituent of the coagulation cascade in terms of its feedback activation roles. Prothrombin also plays a role in maintaining vascular integrity during development and postnatal life. Mutations in Prothrombin lead to various forms of thrombosis and dysprothrombinemia. Prothrombin is a 72 kDa blood clotting glycoprotein formed by and stored in the Liver. Prothrombin is present in the blood plasma and is converted to the key blood clotting agent thrombin, when blood vessels are damaged. Factor VII, another important haemostasis protein can be converted to VIIa by Factor IXa or Thrombin.Synonyms: Coagulation factor II

Gen-ID: 2147

NCBI Accession: NP_000497

UniProt: P00734

Pathways: Komplementsystem, Peptide Hormone Metabolism, Regulation of G-Protein Coupled Receptor Protein Signaling