BCL3 Antikörper (Biotin)

Produktnummer ABIN950628

Der Hamster Monoklonal Anti-BCL3-Antikörper wurde für EIA validiert. Er ist geeignet, BCL3 in Proben von Human und Maus zu detektieren.

Kurzübersicht für BCL3 Antikörper (Biotin) (ABIN950628)

Target: BCL3 (B-Cell CLL/lymphoma 3 (BCL3))

Reaktivität: Human, Maus

Wirt: Hamster

Klonalität: Monoklonal

Konjugat: Dieser BCL3 Antikörper ist konjugiert mit Biotin

Applikation: Enzyme Immunoassay (EIA)

Klon: Ham150-3-5

Produktdetails anti-BCL3 Antikörper (Biotin)

Spezifität: Recognizes B-cell Leukemia/lymphoma 3

Kreuzreaktivität (Details): Species reactivity (tested):Human and Mouse.

Aufreinigung: Protein G Affinity Chromatography.

Immunogen: Recombinant Bcl-3-6-histidine tag from Armenian Hamster. Fusion Partner: SP2/0 myeloma.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.1 mg/mL

Buffer: PBS containing 0.02 % Sodium Azide as preservative and EIA grade BSA as a stabilizing protein to bring total protein concentration to 4-5 mg/mL.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu BCL3

Target: BCL3 (B-Cell CLL/lymphoma 3 (BCL3))

Andere Bezeichnung: Bcl-3

Hintergrund: B cell Lymphoma 3 is a member of the IkB subfamily of inhibitors. This subfamily is part of the NF-kB transcription factor protein family and it is suggested that a balance in the concentration of various NF-kB family members regulates apoptosis and survival of activated T cells. Bcl-3 has been shown to have versatile functions such as cytoplasmic activation of p50 homodimers, translocation to the nucleus, and modulation of the transcriptional machinery in the nucleus. Bcl-3 activity often relies on several nuclear interacting proteins such as Tip60, Jab1, Bard1, and Pirin. The Mouse Bcl-3 coding region exhibits 80 % homology with Human Bcl-3 which is associated with human B-cell chronic lymphocytic leukemias (CLLs). Bcl-3 is detected in various tissues such as spleen and other lymphoid organs.Synonyms: B-cell lymphoma 3-encoded protein, BCL3, BCL4, D19S37

Gen-ID: 602

NCBI Accession: NP_005169

UniProt: P20749

Pathways: NF-kappaB Signalweg, Maintenance of Protein Location, Protein targeting to Nucleus