Telefon:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@antikoerper-online.de

CD25 Antikörper

IL2RA Reaktivität: Human FACS, IP Wirt: Maus Monoclonal MEM-140 unconjugated
Produktnummer ABIN94049
  • Target Alle CD25 (IL2RA) Antikörper anzeigen
    CD25 (IL2RA) (Interleukin 2 Receptor, alpha (IL2RA))
    Reaktivität
    • 186
    • 127
    • 38
    • 9
    • 6
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    Human
    Wirt
    • 148
    • 98
    • 80
    • 2
    • 1
    Maus
    Klonalität
    • 248
    • 77
    • 2
    Monoklonal
    Konjugat
    • 112
    • 34
    • 29
    • 27
    • 22
    • 11
    • 8
    • 8
    • 6
    • 6
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser CD25 Antikörper ist unkonjugiert
    Applikation
    • 222
    • 91
    • 57
    • 50
    • 43
    • 40
    • 22
    • 18
    • 14
    • 14
    • 10
    • 9
    • 7
    • 6
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Flow Cytometry (FACS), Immunoprecipitation (IP)
    Spezifität
    The antibody MEM-140 reacts with an extracellular epitope of CD25 (Interleukin-2 receptor alpha chain), a 55 kDa type I transmembrane glycoprotein expressed on activated B and T lymphocytes, activated monocytes/macrophages and on CD4+ T lymphocytes (T regulatory cells), it is lost on resting B and T lymphocytes.
    Kreuzreaktivität (Details)
    Human
    Aufreinigung
    Purified by sequential steps of physicochemical fractionation (differential precipitation and solid-phase chromatography methods).
    Reinheit
    > 95 % (by SDS-PAGE)
    Immunogen
    PHA-activated peripheral blood leucocytes
    Klon
    MEM-140
    Isotyp
    IgM
    Top Product
    Discover our top product IL2RA Primärantikörper
  • Applikationshinweise
    Immunoprecipitation: Excellent for immunoisolation of CD25+ cells.
    Flow cytometry: Recommended dilution: 1 μg/mL.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    1 mg/mL
    Buffer
    Tris buffered saline (TBS), pH 8.0, 15 mM sodium azide
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Do not freeze.
    Lagerung
    4 °C
    Informationen zur Lagerung
    Store at 2-8°C. Do not freeze.
  • Target
    CD25 (IL2RA) (Interleukin 2 Receptor, alpha (IL2RA))
    Andere Bezeichnung
    CD25 (IL2RA Produkte)
    Synonyme
    CD25 antikoerper, IDDM10 antikoerper, IL2R antikoerper, TCGFR antikoerper, IL2RAC antikoerper, IL-2RA antikoerper, Il2r antikoerper, Ly-43 antikoerper, interleukin 2 receptor subunit alpha antikoerper, interleukin-2 receptor subunit alpha-like antikoerper, interleukin 2 receptor, alpha chain antikoerper, IL2RA antikoerper, Il2ra antikoerper, LOC100222957 antikoerper
    Hintergrund
    Interleukin 2 receptor subunit alpha,CD25 (IL2Ralpha, Tac) is a ligand-binding alpha subunit of interleukin 2 receptor (IL2R). Together with beta and gamma subunit CD25 constitues the high affinity IL2R, whereas CD25 alone serves as the low affinity IL2R. CD25 expression rapidly increases upon T cell activation. The 55 kDa CD25 Molecule is enzymatically cleaved and shed from the cell surface as a soluble 45 kDa s-Tac, whose concentration in serum can be used as a marker of T cell activation. Expression of CD25 indicates the neoplastic phenotype of mast cells. Humanized anti CD25 antibodies represent a useful tool to reduce the incidence of allograft rejection as well as the severity of graft versus host reaction, and radioimmunoconjugates of anti-CD25 antibodies can be used against CD25 expressing lymphomas.,IL-2R α, chain, IL-2-RA, IL2-RA, p55, TAC antigen, IDDM10, TCGFR
    Gen-ID
    3559
    UniProt
    P01589
    Pathways
    JAK-STAT Signalweg, Growth Factor Binding, Activated T Cell Proliferation
Sie sind hier:
Kundenservice