Cyclin D1 Antikörper (Middle Region)

Produktnummer ABIN926904

Dieses Anti-Cyclin D1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von Cyclin D1 in WB. Geeignet für Human, Maus, Ratte, Rind (Kuh), Huhn, Hund, Zebrafisch (Danio rerio) und Xenopus laevis.

Kurzübersicht für Cyclin D1 Antikörper (Middle Region) (ABIN926904)

Target: Cyclin D1 (CCND1)

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Huhn, Hund, Zebrafisch (Danio rerio), Xenopus laevis

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Cyclin D1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-Cyclin D1 Antikörper

Bindungsspezifität: Middle Region

Kreuzreaktivität: Maus, Ratte (Rattus), Hund, Rind (Kuh), Zebrafisch (Brachydanio rerio), Frosch, Huhn

Aufreinigung: Purified

Immunogen: CCND1 antibody was raised in rabbit using the middle region of CCND1 as the immunogen

Anwendungsinformationen

Applikationshinweise: WB: 0.2-1 µg/mL
Optimal conditions should be determined by the investigator.

Kommentare:

CCND1 Blocking Peptide, catalog no. 33R-1076, is also available for use as a blocking control in assays to test for specificity of this CCND1 antibody

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Konzentration: Lot specific

Buffer: Lyophilized powder. Add 50 µL of distilled water. Final antibody concentration is 1 mg/mL in PBS buffer.

Handhabung: Avoid repeated freeze/thaw cycles.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 4 °C, following reconstitution, aliquot and store at -20 °C.

Details zu Cyclin D1

Target: Cyclin D1 (CCND1)

Andere Bezeichnung: CCND1

Hintergrund: CCND1 belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis. Synonyms: Polyclonal CCND1 antibody, Anti-CCND1 antibody, cyclin D1 antibody, BCL1 antibody, D11S287E antibody, PRAD1 antibody, U21B31 antibody.

Pathways: PI3K-Akt Signalweg, Zellzyklus, Mitotic G1-G1/S Phases, ER-Nucleus Signaling