Cyclin D1 Antikörper (AA 68-97)
Kurzübersicht für Cyclin D1 Antikörper (AA 68-97) (ABIN3030588)
Target
Alle Cyclin D1 (CCND1) Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
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Bindungsspezifität
- AA 68-97
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Verwendungszweck
- Cyclin D1 Antibody / CCND1
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Homologie
- Bovine
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Aufreinigung
- Antigen affinity purified
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Immunogen
- A portion of amino acids 68-97 from the human protein was used as the immunogen for this Cyclin D1 antibody.
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Isotyp
- Ig Fraction
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anti-Cyclin D1 (CCND1) (AA 61-110) antibody
CCND1 Reaktivität: Maus WB, FACS, IHC (p), IF (cc), IF (p), IHC (fro) Wirt: Kaninchen Polyclonal unconjugated
anti-Cyclin D1 (CCND1) (AA 68-97) antibodyCCND1 Reaktivität: Human, Maus WB, IF, IHC (p) Wirt: Kaninchen Polyclonal RB8066 unconjugated
anti-Cyclin D1 (CCND1) (AA 1-295) antibodyCCND1 Reaktivität: Human, Maus WB, IHC, ELISA, FACS Wirt: Maus Monoclonal 1F7F5 unconjugated
anti-Cyclin D1 (CCND1) (AA 167-295) antibodyCCND1 Reaktivität: Human IHC, ELISA, FACS, ICC Wirt: Maus Monoclonal 3B6G3 unconjugated
anti-Cyclin D1 (CCND1) (C-Term) antibodyCCND1 Reaktivität: Human WB, IHC, IF, IP Wirt: Kaninchen Polyclonal unconjugated
anti-Cyclin D1 (CCND1) antibodyKD Validated CCND1 Reaktivität: Human WB, FACS Wirt: Kaninchen Monoclonal 23GB735 unconjugated Recombinant Antibody
anti-Cyclin D1 (CCND1) antibodyCCND1 Reaktivität: Human WB, IHC, FACS, IF Wirt: Maus Monoclonal DCS-6 unconjugated
anti-Cyclin D1 (CCND1) (C-Term) antibodyCCND1 Reaktivität: Human WB, IF, IP Wirt: Kaninchen Polyclonal unconjugated
anti-Cyclin D1 (CCND1) (C-Term) antibodyCCND1 Reaktivität: Human, Maus, Ratte WB, IHC, IF, ICC Wirt: Kaninchen Polyclonal unconjugated
anti-Cyclin D1 (CCND1) antibodyCCND1 Reaktivität: Human IHC Wirt: Maus Monoclonal CCND1-2593 unconjugated
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Applikationshinweise
- Titration of the Cyclin D1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Liquid
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Buffer
- In 1X PBS, pH 7.4, with 0.09 % sodium azide
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Konservierungsmittel
- Sodium azide
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Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Handhabung
- Avoid repeated freeze-thaw cycles
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Lagerung
- -20 °C
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Informationen zur Lagerung
- Aliquot the Cyclin D1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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- Cyclin D1 (CCND1)
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Hintergrund
- CCND1 is the regulatory component of the Cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. CyclinD-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. [UniProt]
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UniProt
- P24385
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Pathways
- PI3K-Akt Signalweg, Zellzyklus, Mitotic G1-G1/S Phases, ER-Nucleus Signaling
Target
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