TLR5 Antikörper (C-Term)

Produktnummer ABIN920613

Der Kaninchen Polyklonal anti-TLR5 Antikörper (ABIN920613) detektiert spezifisch TLR5 in WB und ICC. Dieser Antikörper reagiert spezifisch mit Proben aus Human und Maus.

Kurzübersicht für TLR5 Antikörper (C-Term) (ABIN920613)

Target: TLR5 (Toll-Like Receptor 5 (TLR5))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TLR5 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunocytochemistry (ICC)

Produktdetails anti-TLR5 Antikörper

Bindungsspezifität: C-Term

Produktmerkmale: Positive Control: Found in the membrane, TLR5 is highly expressed in ovary and in peripheral blood leukocytes, especially in monocytes, less in CD11c+ immature dendritic cells. Also detected in prostate and testis.

Aufreinigung: Antigen Immunoaffinity purified

Immunogen: Rabbit polyclonal TLR5 antibody was raised against a peptide corresponding to 15 amino acids near the carboxy terminus of TLR5.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot: use at 1-2 µg/mL. Immunocytochemistry: use at 10 µg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: Phosphate buffered saline with 0.02% sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Details zu TLR5

Target: TLR5 (Toll-Like Receptor 5 (TLR5))

Hintergrund: Toll-like receptors (TRLs) are evolutionarily conserved pattern-recognition molecules resembling the toll proteins that mediate antimicrobial responses in Drosophila. These proteins recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. The TLRs act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors so the organism can respond to potential infection. TLR5 recognizes flagellin from both Gram-positive and Gram-negative bacteria and will cause the activation of NF-B, leading to the activation of TNF-alpha and other cytokines. A common TLR5 stop codon polymorphism that disrupts TLR5 signaling is associated with susceptibility to Legionnaires' disease and demonstrates the importance of TLR5 in the innate immune response. Synonyms:

Molekulargewicht: 97.8 kDa

Pathways: TLR Signalweg, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Toll-Like Receptors Cascades