PARP3 Antikörper (AA 301-400)
Kurzübersicht für PARP3 Antikörper (AA 301-400) (ABIN873020)
Target
Alle PARP3 Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
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Bindungsspezifität
- AA 301-400
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Kreuzreaktivität
- Maus
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Homologie
- Human,Rat,Horse,Rabbit
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Aufreinigung
- Purified by Protein A.
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Immunogen
- KLH conjugated synthetic peptide derived from human PARP3
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Isotyp
- IgG
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Applikationshinweise
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WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 -
Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Liquid
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Konzentration
- 1 μg/μL
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Buffer
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
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Konservierungsmittel
- ProClin
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Vorsichtsmaßnahmen
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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Lagerung
- 4 °C,-20 °C
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Informationen zur Lagerung
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
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Haltbarkeit
- 12 months
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- PARP3 (Poly (ADP-Ribose) Polymerase Family, Member 3 (PARP3))
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Andere Bezeichnung
- PARP3
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Hintergrund
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Synonyms: hPARP3, IRT1, NAD+ ADP ribosyltransferase 3, pADPRT 3, Poly[ADP ribose] synthetase 3, ADP ribosyltransferase NAD+, poly ADP ribose, ADPRT-3, ADPRT3, ADPRTL2, ADPRTL3, hPARP 3, hPARP-3, IRT 1, IRT1, NAD+ ADP-ribosyltransferase 3, NAD+ ADP ribosyltransferase 3, pADPRT-3, pADPRT3, PARP 3, PARP-3, PARP3, Poly ADP ribose polymerase family, member 3, Poly ADP ribose synthetase 3, Poly [ADP-ribose] polymerase 3, Poly[ADP-ribose] synthase 3.
Background: Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. May link the DNA damage surveillance network to the mitotic fidelity checkpoint. Negatively influences the G1/S cell cycle progression without interfering with centrosome duplication. Binds DNA. May be involved in the regulation of PRC2 and PRC3 complex-dependent gene silencing.Tissue specificity: Widely expressed, the highest levels are in the kidney, skeletal muscle, liver, heart and spleen, also detected in pancreas, lung, placenta, brain, leukocytes, colon, small intestine, ovary, testis, prostate and thymus.
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Gen-ID
- 10039
Target
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