NLRP12 Antikörper (AA 176-270)

Produktnummer ABIN872372

Der Kaninchen Polyklonal Anti-NLRP12 Antikörper wurde für ELISA, IF (cc), IF (p), IHC (p) und IHC (fro) validiert. Er ist geeignet, NLRP12 in Proben von Human und Ratte zu detektieren.

Kurzübersicht für NLRP12 Antikörper (AA 176-270) (ABIN872372)

Target: NLRP12 (NLR Family, Pyrin Domain Containing 12 (NLRP12))

Reaktivität: Human, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NLRP12 Antikörper ist unkonjugiert

Applikation: ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Produktdetails anti-NLRP12 Antikörper

Bindungsspezifität: AA 176-270

Kreuzreaktivität: Human, Ratte

Homologie: Mouse,Dog,Cow,Sheep,Pig,Horse,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human NALP12

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Details zu NLRP12

Target: NLRP12 (NLR Family, Pyrin Domain Containing 12 (NLRP12))

Andere Bezeichnung: NALP12

Hintergrund:

Synonyms: CLR19.3, FCAS2, Monarch 1, Monarch-1, NACHT, leucine rich repeat and PYD containing 12, NACHT, LRR and PYD containing protein 12, NACHT, LRR and PYD domains-containing protein 12, NAL12_HUMAN, NLR family, pyrin domain containing 12, NLRP12, Nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 12, PAN6, PYPAF7, PYRIN containing APAF1 like protein 7, PYRIN-containing APAF1-like protein 7, Regulated by nitric oxide, RNO, RNO2.

Background: May mediate activation of CASP1 via ASC and promote activation of NF-kappa-B via IKK.NALP proteins are cytoplasmic proteins that form a subfamily within the larger CATERPILLER family and are thought to play a crucial role in cell proliferation and reproduction. Like all other NALP family members, NALP12, also known as Monarch-1, has a C-terminal leucine-rich repeat (LRR) region, an N-terminal Pyrin domain (PYD) followed by a NACHT domain, and a NACHT-associated domain. NALP12 is thought to act as an attenuating factor of inflammation by suppressing inflammatory responses such as NF-kB activation by TLR-signaling molecules MyD88, IRAK-1, TRAF6 and RIPK1 in activated monocytes. Recent evidence suggests that mutations in NALP12 result in hereditary periodic fever syndromes.

Gen-ID: 91662

Pathways: Positive Regulation of Endopeptidase Activity, Inflammasome