NLRP12 Antikörper

Produktnummer ABIN3032016

Der Kaninchen Polyklonal anti-NLRP12 Antikörper (ABIN3032016) detektiert spezifisch NLRP12 in WB und ELISA. Dieser Antikörper reagiert spezifisch mit Proben aus Human und Maus.

Kurzübersicht für NLRP12 Antikörper (ABIN3032016)

Target: NLRP12 (NLR Family, Pyrin Domain Containing 12 (NLRP12))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NLRP12 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-NLRP12 Antikörper

Verwendungszweck: Anti-NLRP12 Antibody

Aufreinigung: Antigen affinity

Immunogen: This anti-NLRP12 antibody was produced from rabbits immunized with human NLRP12 recombinant protein.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Titration of the anti-NLRP12 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the anti-NLRP12 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Details zu NLRP12

Target: NLRP12 (NLR Family, Pyrin Domain Containing 12 (NLRP12))

Andere Bezeichnung: NLRP12

Hintergrund: NALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP12, have an N-terminal pyrin (MEFV, MIM 608107) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. The long NALP, NALP1 (MIM 606636), also has a C-terminal extension containing a function to find domain (FIIND) and a caspase recruitment domain (CARD). NALPs are implicated in the activation of proinflammatory caspases (e.g., CASP1, MIM 147678) via their involvement in multiprotein complexes called inflammasomes.

UniProt: P59046

Pathways: Positive Regulation of Endopeptidase Activity, Inflammasome