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KAP1 Antikörper (AA 827-831)

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch KAP1 in WB. Er zeigt eine Reaktivität gegenüber Human.
Produktnummer ABIN871735

Kurzübersicht für KAP1 Antikörper (AA 827-831) (ABIN871735)

Target

Alle KAP1 (TRIM28) Antikörper anzeigen
KAP1 (TRIM28) (Tripartite Motif Containing 28 (TRIM28))

Reaktivität

  • 116
  • 55
  • 53
  • 10
  • 10
  • 9
  • 7
  • 5
  • 4
  • 2
  • 1
  • 1
  • 1
Human

Wirt

  • 118
  • 18
  • 4
Kaninchen

Klonalität

  • 109
  • 31
Polyklonal

Konjugat

  • 74
  • 8
  • 8
  • 4
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
Dieser KAP1 Antikörper ist unkonjugiert

Applikation

  • 92
  • 48
  • 42
  • 28
  • 27
  • 26
  • 26
  • 25
  • 20
  • 20
  • 8
  • 4
  • 4
  • 3
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
Western Blotting (WB)
  • Bindungsspezifität

    • 23
    • 15
    • 10
    • 8
    • 6
    • 6
    • 6
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 827-831

    Spezifität

    The antibody detects endogenous level of total TIF1b protein.

    Aufreinigung

    Affinity purified

    Immunogen

    Peptide sequence around AA 827-831 (L-S-G-G-P) derived from Human TIF1b. Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates.
  • Applikationshinweise

    Western blotting: 1:500-1:1000

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    1 mg/mL

    Buffer

    Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    4 °C/-20 °C

    Informationen zur Lagerung

    Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
  • Target

    KAP1 (TRIM28) (Tripartite Motif Containing 28 (TRIM28))

    Andere Bezeichnung

    TIF1beta

    Hintergrund

    Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression. Recruitment of SETDB1 induces heterochromatinization. May play a role as a coactivator for CEBPB and NR3C1 in the transcriptional activation of ORM1. Also corepressor for ERBB4. Inhibits E2F1 activity by stimulating E2F1-HDAC1 complex formation and inhibiting E2F1 acetylation. May serve as a partial backup to prevent E2F1-mediated apoptosis in the absence of RB1. Important regulator of CDKN1A/p21(CIP1). Has E3 SUMO-protein ligase activity toward itself via its PHD-type zinc finger.

    Molekulargewicht

    110 kDa

    Gen-ID

    10155

    NCBI Accession

    NP_005753

    UniProt

    Q13263

    Pathways

    Hedgehog Signalweg, Positive Regulation of Response to DNA Damage Stimulus
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